Protein: D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)

Gene: D2HDH, D2HGDH
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q8N465

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006089 - lactate metabolic process
GO:0006103 - 2-oxoglutarate metabolic process
GO:0006108 - malate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1325824

ZN462
Zinc finger protein 462

3

0

High-throughput

0.646

High

641804

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

2

High-throughput

0.621

High

104695

F6VUV4
Dehydrogenase/reductase 4 like 2

3

2

High-throughput

0.585

High

1325847

TRM1
tRNA

2

0

High-throughput

0.576

High

1153500

RAB30
Ras-related protein Rab-30

2

1

High-throughput

0.574

High

1245784

DR4L2
Dehydrogenase/reductase SDR family member 4-like 2

2

4

High-throughput

0.552

High

532768

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.536

High

888795

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

2

High-throughput

0.536

High

1109625

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

1220643

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.536

High

1238217

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1245311

WDR59
GATOR2 complex protein WDR59

1

1

High-throughput

0.536

High

1325821

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.536

High

1325826

IF140
Intraflagellar transport protein 140 homolog

1

2

High-throughput

0.536

High

1325831

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

1325849

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.536

High

1325857

MTUS1
Microtubule-associated tumor suppressor 1

1

1

High-throughput

0.536

High

1325861

GIT1
ARF GTPase-activating protein GIT1

1

2

High-throughput

0.536

High

1325866

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.536

High

1154395

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

67483

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.513

High

225206

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

702996

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

908765

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

946506

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

1093384

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.513

High

1201685

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.513

High

1219849

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.513

High

1228549

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.513

High

1242596

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1246881

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

1294048

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.513

High

1315216

TRM44
Probable tRNA

1

0

High-throughput

0.513

High

1325810

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.513

High

1325820

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1325838

TRABD
TraB domain-containing protein

1

0

High-throughput

0.513

High

1325843

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1325844

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.513

High

1325852

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1325858

TTF2
Transcription termination factor 2

1

0

High-throughput

0.513

High

1325862

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

136413

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

1

High-throughput

0.489

High

231726

PEX1
Peroxisomal ATPase PEX1

1

4

High-throughput

0.489

High

295753

AP1G2
AP-1 complex subunit gamma-like 2

1

1

High-throughput

0.489

High

298610

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.489

High

331774

MTMR5
Myotubularin-related protein 5

1

2

High-throughput

0.489

High

335332

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

2

High-throughput

0.489

High

343613

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.489

High

832546

ETV3
ETS translocation variant 3

1

1

High-throughput

0.489

High

896418

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.489

High

898114

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.489

High

1005694

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.489

High

1124495

MAP7
Ensconsin

1

2

High-throughput

0.489

High

1153194

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

3

High-throughput

0.489

High

1231848

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.489

High

1247269

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.489

High

1251377

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.489

High

1259346

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.489

High

1309451

CEP97
Centrosomal protein of 97 kDa

1

1

High-throughput

0.489

High

1311339

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.489

High

1322260

FCSK
L-fucose kinase

1

1

High-throughput

0.489

High

1325807

SHKB1
SH3KBP1-binding protein 1

1

1

High-throughput

0.489

High

1325808

IASPP
RelA-associated inhibitor

1

4

High-throughput

0.489

High

1325809

CTF18
Chromosome transmission fidelity protein 18 homolog

1

3

High-throughput

0.489

High

1325811

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.489

High

1325812

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

4

High-throughput

0.489

High

1325813

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.489

High

1325816

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.489

High

1325819

HOOK2
Protein Hook homolog 2

1

3

High-throughput

0.489

High

1325829

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.489

High

1325834

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.489

High

1325839

ESRP2
Epithelial splicing regulatory protein 2

1

1

High-throughput

0.489

High

1325840

IF122
Intraflagellar transport protein 122 homolog

1

4

High-throughput

0.489

High

1325853

TBK1
Serine/threonine-protein kinase TBK1

1

5

High-throughput

0.489

High

1325854

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.489

High

1325859

TBD2B
TBC1 domain family member 2B

1

2

High-throughput

0.489

High

1325860

CD11A
Cyclin-dependent kinase 11A

1

2

High-throughput

0.489

High

1325864

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1254627

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

537512

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.470

High

653434

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

945042

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.437

High

1325855

APC7
Anaphase-promoting complex subunit 7

1

3

High-throughput

0.437

High

841058

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

1195413

Q4KMX6
Anaphase-promoting complex subunit 7

1

3

High-throughput

0.407

High

290335

KS6A4
Ribosomal protein S6 kinase alpha-4

1

0

High-throughput

0.279

Low

322428

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

344247

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.279

Low

457555

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

464459

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low

821744

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.279

Low

829243

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

873406

LSS
Lanosterol synthase

1

0

High-throughput

0.279

Low

930335

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.279

Low

1017793

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1065817

SLFN5
Schlafen family member 5

1

0

High-throughput

0.279

Low

1091889

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1101284

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.279

Low

1133840

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

0

High-throughput

0.279

Low

1134984

CUL7
Cullin-7

1

0

High-throughput

0.279

Low

1144286

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.279

Low

1185201

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

1187158

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

1193156

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.279

Low

1201851

PKHG4
Puratrophin-1

1

0

High-throughput

0.279

Low

1212172

ODAD2
Outer dynein arm-docking complex subunit 2

1

0

High-throughput

0.279

Low

1247606

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.279

Low

1278409

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.279

Low

1280655

PKHH3
Pleckstrin homology domain-containing family H member 3

1

0

High-throughput

0.279

Low

1281217

VP13B
Intermembrane lipid transfer protein VPS13B

1

0

High-throughput

0.279

Low

1290452

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

1294703

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

1309129

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.279

Low

1324951

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.279

Low

1325805

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.279

Low

1325806

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1325814

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.279

Low

1325815

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.279

Low

1325817

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.279

Low

1325818

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

1325822

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1325823

SPTCS
Spatacsin

1

0

High-throughput

0.279

Low

1325825

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

1325827

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

1325828

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

1325830

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1325832

THUM3
tRNA

1

0

High-throughput

0.279

Low

1325833

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

1325835

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1325836

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.279

Low

1325837

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1325841

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

1325842

ARHG4
Rho guanine nucleotide exchange factor 4

1

0

High-throughput

0.279

Low

1325845

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

1325846

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.279

Low

1325848

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.279

Low

1325850

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1325851

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1325856

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.279

Low

1325863

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.279

Low

1325865

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025