Protein: HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL)

Gene: HMGC2, HMGCLL1
Organism: Homo sapiens
Interactions: 14
UniProt ID: Q8TB92

Gene Ontology (top 5):
GO:0004419 - hydroxymethylglutaryl-CoA lyase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0006552 - L-leucine catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777622

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

14

High-throughput

0.839

High

1257735

VP13C
Intermembrane lipid transfer protein VPS13C

2

0

High-throughput

0.602

High

72923

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

14

High-throughput

0.575

High

387991

FIBG
Fibrinogen gamma chain

1

1

High-throughput

0.536

High

999388

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.536

High

999666

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.536

High

387299

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

390921

TRFE
Serotransferrin

1

0

High-throughput

0.513

High

391149

HEMO
Hemopexin

1

0

High-throughput

0.513

High

648208

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.513

High

750510

LSP1
Lymphocyte-specific protein 1

1

0

High-throughput

0.513

High

273776

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

2

High-throughput

0.489

High

1348154

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

1

Small-scale

0.479

High

369895

CO3
Complement C3

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025