Protein: HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)

Gene: HMGCL
Organism: Homo sapiens
Interactions: 59
UniProt ID: P35914

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004419 - hydroxymethylglutaryl-CoA lyase activity
GO:0005198 - structural molecule activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777622

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

3

14

High-throughput

0.839

High

777629

MGME1
Mitochondrial genome maintenance exonuclease 1

4

1

High-throughput

0.683

High

322206

GLSK
Glutaminase kidney isoform, mitochondrial

3

1

High-throughput

0.656

High

560830

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

1

High-throughput

0.656

High

777600

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

3

High-throughput

0.656

High

777605

FOLC
Folylpolyglutamate synthase, mitochondrial

3

1

High-throughput

0.656

High

777623

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

3

1

High-throughput

0.650

High

322585

FBX21
F-box only protein 21

3

0

High-throughput

0.622

High

777625

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.611

High

539295

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

2

1

High-throughput

0.601

High

167839

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.578

High

777628

MIPEP
Mitochondrial intermediate peptidase

2

0

High-throughput

0.576

High

777599

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.561

High

777611

PLEC
Plectin

2

0

High-throughput

0.559

High

425883

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.536

High

686694

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

777637

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

777603

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.513

High

777613

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

777620

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

777621

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

777632

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

727701

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.508

High

777634

ATS10
A disintegrin and metalloproteinase with thrombospondin motifs 10

1

1

High-throughput

0.508

High

507613

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

777604

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.494

High

777609

HES1
Transcription factor HES-1

1

0

High-throughput

0.486

High

777610

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.486

High

777630

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.486

High

777598

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

777607

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

777627

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

320632

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

399943

CATA
Catalase

1

0

High-throughput

0.458

High

777597

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

132827

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

1

High-throughput

0.445

High

777602

ARL4C
ADP-ribosylation factor-like protein 4C

1

4

High-throughput

0.445

High

777640

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

777616

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

777624

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.437

High

777635

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

518583

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.426

High

586238

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.426

High

777606

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

777612

THTR
Thiosulfate sulfurtransferase

1

0

High-throughput

0.426

High

777614

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.426

High

777615

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.426

High

777617

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.426

High

777618

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

High-throughput

0.426

High

777631

TR61B
tRNA

1

0

High-throughput

0.426

High

777636

NT5D2
5'-nucleotidase domain-containing protein 2

1

0

High-throughput

0.426

High

777638

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.426

High

777639

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

0

High-throughput

0.426

High

777601

PEX5
Peroxisomal targeting signal 1 receptor

1

2

Small-scale

0.408

High

777633

MS4A7
Membrane-spanning 4-domains subfamily A member 7

1

0

High-throughput

0.282

High

377430

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

777608

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

777619

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.232

Low

777626

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025