Protein: HEMO
Hemopexin (Beta-1B-glycoprotein)

Gene: HEMO, HPX
Organism: Homo sapiens
Interactions: 74
UniProt ID: P02790

Gene Ontology (top 5):
GO:0002639 - positive regulation of immunoglobulin production
GO:0002925 - positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391146

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

3

2

High-throughput

0.662

High

391147

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.638

High

391115

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

High-throughput

0.571

High

391121

FGFR1
Fibroblast growth factor receptor 1

2

3

High-throughput

0.571

High

391129

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

1

High-throughput

0.571

High

391134

CDC42
Cell division control protein 42 homolog

2

1

High-throughput

0.571

High

391126

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

391166

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

0

High-throughput

0.547

High

132980

MATN2
Matrilin-2

1

11

High-throughput

0.536

High

210669

KLK10
Kallikrein-10

1

7

High-throughput

0.536

High

389912

ALBU
Albumin

1

1

High-throughput

0.536

High

391139

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

2

High-throughput

0.536

High

391156

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.536

High

391123

BRAF
Serine/threonine-protein kinase B-raf

2

2

High-throughput

0.521

High

391149

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

391116

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

391122

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.489

High

391128

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

391137

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.489

High

391143

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

391150

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.489

High

391152

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.489

High

391153

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

391155

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

391161

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

391164

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

391165

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

391158

P63
Tumor protein 63

1

1

High-throughput

0.481

High

127240

LEG8
Galectin-8

1

5

Small-scale

0.479

High

366144

HPT
Haptoglobin

1

1

High-throughput

0.479

High

369292

A1AT
Alpha-1-antitrypsin

1

2

High-throughput

0.479

High

369423

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.479

High

387194

APOA1
Apolipoprotein A-I

1

2

High-throughput

0.479

High

387769

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.479

High

390267

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

391119

CO4A2

1

20

High-throughput

0.479

High

391120

CLUS
Clusterin

1

4

High-throughput

0.479

High

391124

LEG3
Galectin-3

1

5

Small-scale

0.479

High

391127

LCN1
Lipocalin-1

1

2

High-throughput

0.479

High

391136

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

391163

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

1

High-throughput

0.479

High

361518

CERU
Ceruloplasmin

1

0

High-throughput

0.458

High

389639

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

390837

TRFE
Serotransferrin

1

0

High-throughput

0.458

High

391114

STAT
Statherin

1

0

High-throughput

0.458

High

391118

PLEK
Pleckstrin

1

0

High-throughput

0.458

High

391125

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

391132

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

391141

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

391117

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

6

High-throughput

0.457

High

391138

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

391140

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

359564

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.439

High

105085

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

348928

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.437

High

391130

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

391148

FBX22
F-box only protein 22

1

2

High-throughput

0.437

High

391151

RUFY2
RUN and FYVE domain-containing protein 2

1

2

High-throughput

0.437

High

391142

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

391154

SNX27
Sorting nexin-27

2

0

High-throughput

0.328

High

391159

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

194452

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

231373

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.279

Low

317771

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

355397

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

391131

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

391133

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

391144

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

391145

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

391160

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

391167

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

391157

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.261

Low

391135

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

391162

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025