Protein: CIC1
Proteasome-interacting protein CIC1 (Core interacting component 1)

Gene: CIC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 229
UniProt ID: P38779

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA
GO:0000502 - proteasome complex
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

754179

HAS1
ATP-dependent RNA helicase HAS1

8

7

Small-scale

0.964

High

754125

NUG1
Nuclear GTP-binding protein NUG1

8

2

Small-scale

0.961

High

638743

SPB4
ATP-dependent rRNA helicase SPB4

7

5

High-throughput

0.956

High

754155

NOG2
Nucleolar GTP-binding protein 2

7

2

Small-scale

0.956

High

744187

MAK5
ATP-dependent RNA helicase MAK5

5

5

High-throughput

0.919

High

754226

DBP10
ATP-dependent RNA helicase DBP10

5

1

High-throughput

0.915

High

699678

DRS1
ATP-dependent RNA helicase DRS1

4

3

High-throughput

0.886

High

754112

CIC1
Proteasome-interacting protein CIC1

3

0

High-throughput

0.806

High

534757

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.789

High

754147

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.789

High

754195

DBP9
ATP-dependent RNA helicase DBP9

2

2

High-throughput

0.754

High

733813

RPF2
Ribosome biogenesis protein RPF2

11

2

Small-scale

0.754

High

742010

NOP4
Nucleolar protein 4

8

3

Small-scale

0.751

High

754162

NOP15
Ribosome biogenesis protein 15

8

3

Small-scale

0.750

High

754133

NOP2
25S rRNA

8

2

Small-scale

0.748

High

754219

YTM1
Ribosome biogenesis protein YTM1

8

5

Small-scale

0.746

High

754190

RRP5
rRNA biogenesis protein RRP5

7

1

High-throughput

0.745

High

754176

NOG1
Nucleolar GTP-binding protein 1

7

1

Small-scale

0.740

High

754132

RLP7
Ribosome biogenesis protein RLP7

6

2

High-throughput

0.731

High

754188

ERB1
Ribosome biogenesis protein ERB1

6

4

Small-scale

0.729

High

754223

MAK21
Ribosome biogenesis protein MAK21

6

4

High-throughput

0.729

High

754151

PESC
Pescadillo homolog

13

0

Small-scale

0.726

High

754186

PUF6
Pumilio homology domain family member 6

6

1

Small-scale

0.724

High

754113

SSF1
Ribosome biogenesis protein SSF1

6

2

Small-scale

0.722

High

754181

ARX1
Probable metalloprotease ARX1

9

0

Small-scale

0.716

High

640935

RL5
Large ribosomal subunit protein uL18

5

1

Small-scale

0.714

High

703045

MRT4
Ribosome assembly factor MRT4

5

2

Small-scale

0.709

High

754120

NOC2
Nucleolar complex protein 2

6

0

Small-scale

0.699

High

754135

UTP10
U3 small nucleolar RNA-associated protein 10

5

1

High-throughput

0.699

High

754220

NOP53
Ribosome biogenesis protein NOP53

5

1

Small-scale

0.699

High

731805

EBP2
rRNA-processing protein EBP2

4

1

High-throughput

0.694

High

145728

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.691

High

548402

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

5

High-throughput

0.691

High

667170

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.691

High

549391

FBRL
rRNA 2'-O-methyltransferase fibrillarin

4

1

High-throughput

0.691

High

754206

BUD20
Bud site selection protein 20

5

0

Small-scale

0.688

High

754115

RPF1
Ribosome production factor 1

4

3

High-throughput

0.687

High

715436

RRP1
Ribosomal RNA-processing protein 1

4

1

Small-scale

0.686

High

754218

MDN1
Midasin

4

1

High-throughput

0.686

High

754228

NOP58
Nucleolar protein 58

4

4

High-throughput

0.686

High

754148

NSA1
Ribosome biogenesis protein NSA1

5

0

Small-scale

0.678

High

624078

DBP2
ATP-dependent RNA helicase DBP2

2

0

High-throughput

0.664

High

597835

PWP1
Periodic tryptophan protein 1

3

5

High-throughput

0.658

High

383128

RL25
Large ribosomal subunit protein uL23

3

1

Small-scale

0.656

High

754160

NOP13
Nucleolar protein 13

3

1

High-throughput

0.656

High

754204

NOC3
Nucleolar complex-associated protein 3

3

3

High-throughput

0.656

High

754207

NOP12
Nucleolar protein 12

3

3

High-throughput

0.656

High

754208

BRX1
Ribosome biogenesis protein BRX1

3

11

High-throughput

0.656

High

754217

NIP7
60S ribosome subunit biogenesis protein NIP7

3

1

High-throughput

0.656

High

754152

SDA1
Protein SDA1

4

0

Small-scale

0.643

High

754216

RRS1
Regulator of ribosome biosynthesis

3

1

High-throughput

0.643

High

594036

MAK11
Protein MAK11

3

5

Small-scale

0.640

High

630858

NLE1
Ribosome assembly protein 4

3

6

Small-scale

0.640

High

634404

SPB1
27S pre-rRNA

3

2

High-throughput

0.640

High

645021

RL16A
Large ribosomal subunit protein uL13A

3

2

High-throughput

0.640

High

704335

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

1

High-throughput

0.640

High

754126

NSA2
Ribosome biogenesis protein NSA2

3

1

Small-scale

0.640

High

696317

PP12
Serine/threonine-protein phosphatase PP1-2

2

1

High-throughput

0.628

High

754114

IPI1
Pre-rRNA-processing protein IPI1

3

0

High-throughput

0.628

High

754136

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

Small-scale

0.628

High

754229

IF6
Eukaryotic translation initiation factor 6

3

0

Small-scale

0.628

High

481152

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.618

High

564282

RL8A
Large ribosomal subunit protein eL8A

1

2

Small-scale

0.618

High

733127

DBP7
ATP-dependent RNA helicase DBP7

1

6

High-throughput

0.618

High

754139

MTR4
ATP-dependent RNA helicase DOB1

1

4

Small-scale

0.618

High

754154

DBP6
ATP-dependent RNA helicase DBP6

1

5

High-throughput

0.618

High

754183

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.618

High

754182

RRP17
Ribosomal RNA-processing protein 17

3

0

High-throughput

0.613

High

754205

RLP24
Ribosome biogenesis protein RLP24

3

0

Small-scale

0.613

High

534977

RL3
Large ribosomal subunit protein uL3

2

1

High-throughput

0.611

High

754161

NAT10
RNA cytidine acetyltransferase

2

1

High-throughput

0.611

High

754232

RRP12
Ribosomal RNA-processing protein 12

2

2

High-throughput

0.611

High

754159

IPI3
Pre-rRNA-processing protein IPI3

3

6

High-throughput

0.599

High

605023

XRN1
5'-3' exoribonuclease 1

2

1

High-throughput

0.594

High

431131

CDC4
Cell division control protein 4

1

7

Small-scale

0.586

High

472175

RL31A
Large ribosomal subunit protein eL31A

2

2

High-throughput

0.584

High

501213

MAK16
Protein MAK16

2

1

High-throughput

0.584

High

698156

AFG2
ATPase family gene 2 protein

2

1

High-throughput

0.584

High

748597

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.584

High

754172

RS15
Small ribosomal subunit protein uS19

2

2

High-throughput

0.584

High

754227

NOP56
Nucleolar protein 56

2

4

High-throughput

0.584

High

405181

RL17A
Large ribosomal subunit protein uL22A

2

1

High-throughput

0.571

High

754127

PSA4
Proteasome subunit alpha type-4

1

0

Small-scale

0.568

High

471772

RL27A
Large ribosomal subunit protein eL27A

2

0

High-throughput

0.559

High

481021

RL23B
Large ribosomal subunit protein uL14B

2

0

Small-scale

0.559

High

710877

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

Small-scale

0.559

High

754124

NOP16
Nucleolar protein 16

2

0

High-throughput

0.559

High

754149

CGR1
rRNA-processing protein CGR1

2

0

Small-scale

0.559

High

754143

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.553

High

754191

HRQ1
ATP-dependent helicase HRQ1

1

3

Small-scale

0.553

High

754158

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

High-throughput

0.541

High

404572

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.536

High

550026

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

584728

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

675465

PSB7
Proteasome subunit beta type-7

1

1

Small-scale

0.536

High

754145

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.536

High

754185

UTP15
U3 small nucleolar RNA-associated protein 15

1

6

High-throughput

0.536

High

754203

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.536

High

754230

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.536

High

471039

RS22A
Small ribosomal subunit protein uS8A

2

3

High-throughput

0.533

High

628021

SIS1
Protein SIS1

2

1

High-throughput

0.521

High

754222

YRA1
RNA annealing protein YRA1

1

3

High-throughput

0.515

High

357671

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

405992

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.513

High

597318

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.513

High

703895

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

Small-scale

0.513

High

732710

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.513

High

754202

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

754170

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

1

High-throughput

0.489

High

754171

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.489

High

754177

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

2

High-throughput

0.489

High

754178

PKH3
Serine/threonine-protein kinase PKH3

1

1

High-throughput

0.489

High

754214

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.489

High

141314

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

405605

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

407030

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

407898

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

413490

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

425935

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

478889

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.479

High

480087

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

480655

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

482865

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

630481

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

631860

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

634589

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.479

High

635573

PWP2
Periodic tryptophan protein 2

1

7

High-throughput

0.479

High

692512

ZUO1
Zuotin

1

3

Small-scale

0.479

High

700393

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.479

High

706256

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

715924

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

729897

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

743253

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

754117

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

754141

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

3

High-throughput

0.479

High

754150

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

754153

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

754157

JJJ1
J protein JJJ1

1

2

Small-scale

0.479

High

754164

RCM1
25S rRNA

1

2

High-throughput

0.479

High

754175

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

754184

RRB1
Ribosome assembly protein RRB1

1

4

High-throughput

0.479

High

754187

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

754193

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.479

High

754194

JIP5
WD repeat-containing protein JIP5

1

7

High-throughput

0.479

High

754196

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

1

High-throughput

0.479

High

754199

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

754200

UTP4
U3 small nucleolar RNA-associated protein 4

1

8

High-throughput

0.479

High

754209

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

754215

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

754221

SSF2
Ribosome biogenesis protein SSF2

1

2

High-throughput

0.479

High

754225

UTP12
U3 small nucleolar RNA-associated protein 12

1

7

High-throughput

0.479

High

754233

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

387900

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

479103

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.458

High

481911

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

635119

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

645427

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

732210

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

746235

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

754121

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

754129

BMT5
25S rRNA

1

0

High-throughput

0.458

High

754134

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

754142

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

754144

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

754198

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

754210

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

376778

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.457

High

399454

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

498916

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.445

High

355473

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

356458

H4
Histone H4

1

1

High-throughput

0.437

High

358051

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

392418

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

408349

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

605998

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

662146

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

663859

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

705143

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

742778

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

754118

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

754119

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.437

High

754128

ATAD2
ATPase histone chaperone YTA7

1

2

High-throughput

0.437

High

754131

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

754163

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

754166

H3
Histone H3

1

2

High-throughput

0.437

High

754167

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

754189

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.437

High

754201

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

754224

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.437

High

754231

H2AZ
Histone H2A.Z

1

2

High-throughput

0.437

High

675416

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.426

High

754146

RL9B
Large ribosomal subunit protein uL6B

1

0

High-throughput

0.426

High

754174

NU116
Nucleoporin NUP116/NSP116

1

0

Small-scale

0.426

High

478169

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

491135

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

511218

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

633203

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

707850

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.407

High

754116

RIX1
Pre-rRNA-processing protein RIX1

6

0

Small-scale

0.380

High

754138

ALB1
Ribosome biogenesis protein ALB1

3

0

Small-scale

0.334

High

754130

ULP2
Ubiquitin-like-specific protease 2

2

0

High-throughput

0.306

High

754165

ORC1
Origin recognition complex subunit 1

2

0

Small-scale

0.305

High

419334

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.279

Low

676031

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

754156

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

754168

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.279

Low

754173

PVH1
Tyrosine-protein phosphatase YVH1

1

0

High-throughput

0.279

Low

754211

DNLI4
DNA ligase 4

1

0

High-throughput

0.279

Low

754213

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

754137

LSM1
Sm-like protein LSm1

1

0

High-throughput

0.269

Low

754169

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.269

Low

419476

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

446155

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

470740

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.249

Low

606635

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

664811

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

688225

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

737160

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.249

Low

752434

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

754122

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.249

Low

754180

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

754192

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

754197

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

754212

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

368031

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

424503

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

754123

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.232

Low

754140

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024