Protein: PTN6
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)

Gene: PTN6, Ptpn6
Organism: Mus musculus
Interactions: 29
UniProt ID: P29351

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0002924 - negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711220

LIRB3
Paired immunoglobulin-like receptor B

6

20

Small-scale

0.721

High

711231

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

Small-scale

0.708

High

711225

LCP2
Lymphocyte cytosolic protein 2

1

3

Small-scale

0.691

High

711218

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

4

Small-scale

0.646

High

711221

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

3

13

Small-scale

0.640

High

683088

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

711215

STAT1
Signal transducer and activator of transcription 1

1

12

Small-scale

0.618

High

711216

STAT3
Signal transducer and activator of transcription 3

1

13

Small-scale

0.618

High

711217

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

711227

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

711229

LRB4A
Leukocyte immunoglobulin-like receptor subfamily B member 4A

2

20

Small-scale

0.608

High

711230

FCRL5
Fc receptor-like protein 5

2

18

Small-scale

0.584

High

711219

DOK1
Docking protein 1

1

15

Small-scale

0.561

High

711214

CD22
B-cell receptor CD22

2

18

Small-scale

0.552

High

705054

I23O1
Indoleamine 2,3-dioxygenase 1

1

1

Small-scale

0.536

High

711234

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

2

Small-scale

0.500

High

651056

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.479

High

664094

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

4

Small-scale

0.479

High

711222

STING
Stimulator of interferon genes protein

1

4

High-throughput

0.479

High

711223

CBLB
E3 ubiquitin-protein ligase CBL-B

1

13

Small-scale

0.479

High

711226

TRAF3
TNF receptor-associated factor 3

1

8

Small-scale

0.479

High

711232

FACD2
Fanconi anemia group D2 protein homolog

1

3

High-throughput

0.479

High

711236

GAB2
GRB2-associated-binding protein 2

1

15

Small-scale

0.479

High

711228

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

Small-scale

0.458

High

98119

E9Q604
Integrin alpha M

1

10

High-throughput

0.457

High

711235

ITA2B
Integrin alpha-IIb

1

10

High-throughput

0.457

High

711233

LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

1

20

Small-scale

0.457

High

711224

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

3

Small-scale

0.445

High

63093

A5D6Q2
Nuclear receptor coactivator 3

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025