HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: LYN (P25911)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.19	1.00	0.436

Property	Details
Experiments	10428862
Identification Methods	experimental interaction detection
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 512
+	Mm
		267114 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		SRC_MOUSE (1-510): 0: 585: 51.96
+	Hs
		249709 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		LCK_HUMAN (1-512): 0: 593: 62.33
+	Hs
		249711 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		YES_HUMAN (1-510): 0: 591: 53.70
+	Hs
		249710 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		FYN_HUMAN (1-510): 0: 588: 53.56
+	Hs
		249714 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		SRC_HUMAN (1-510): 0: 584: 51.87
+	Mm
		267113 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		ABL1_MOUSE (31-509): 1.02e-170: 513: 38.01
+	Mm
		683093 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		LYN_MOUSE (1-512): 0: 621: 100.00
+	Mm
		267116 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		CSK_MOUSE (64-503): 4.24e-174: 499: 38.19
+	Hs
		463726 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		LYN_HUMAN (1-512): 0: 617: 96.09
+	Hs
		473465 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		HCK_HUMAN (1-512): 0: 606: 71.48
+	Hs
		463208 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		YES_HUMAN (1-510): 0: 591: 53.70
+	Hs
		249704 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		ABL1_HUMAN (31-509): 1.21e-170: 513: 38.01
+	Hs
		557444 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		SRC_HUMAN (1-510): 0: 584: 51.87
+	Hs
		249725 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		CSK_HUMAN (64-503): 1.49e-174: 500: 38.19
+	Hs
		486706 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		FGR_HUMAN (1-510): 0: 572: 53.80
+	Hs
		249726 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		TXK_HUMAN (21-503): 2.19e-167: 485: 37.25
+	Mm
		362440 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		ABL1_MOUSE (31-509): 1.02e-170: 513: 38.01
+	Hs
		362358 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ABL1_HUMAN (31-509): 1.21e-170: 513: 38.01
+	Mm
		666041 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		TEC_MOUSE (2-506): 1.59e-171: 499: 33.59
+	Mm
		834249 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		CSK_MOUSE (64-503): 4.24e-174: 499: 38.19