Protein: 2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)

Gene: 2AAA, Ppp2r1a
Organism: Mus musculus
Interactions: 46
UniProt ID: Q76MZ3

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994011

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

20

Small-scale

0.757

High

1013629

TNIK
Traf2 and NCK-interacting protein kinase

1

15

High-throughput

0.691

High

977639

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

20

Small-scale

0.618

High

312157

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

13

High-throughput

0.590

High

108319

G3X9E8
Protein phosphatase 2, regulatory subunit B'', alpha

1

9

Small-scale

0.553

High

629330

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.536

High

1190155

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

1

High-throughput

0.536

High

1260676

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

2

High-throughput

0.536

High

97970

RYR2
Ryanodine receptor 2

1

1

High-throughput

0.514

High

1260678

MYOME
Myomegalin

1

0

High-throughput

0.513

High

1260679

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.513

High

1224106

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

772564

IRS1
Insulin receptor substrate 1

1

4

Small-scale

0.484

High

205057

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.479

High

205263

AXIN1
Axin-1

1

2

Small-scale

0.479

High

205291

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

4

Small-scale

0.479

High

267246

TRI18
E3 ubiquitin-protein ligase Midline-1

1

10

Small-scale

0.479

High

530845

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.479

High

921269

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

Small-scale

0.479

High

927851

ATX1
Ataxin-1

1

2

High-throughput

0.479

High

989995

1433Z
14-3-3 protein zeta/delta

1

15

High-throughput

0.479

High

1021585

RGS14
Regulator of G-protein signaling 14

1

2

High-throughput

0.479

High

1190336

Q3UJF1
Histone deacetylase

1

14

High-throughput

0.479

High

1191089

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

2

High-throughput

0.479

High

1222307

KSR1
Kinase suppressor of Ras 1

1

6

Small-scale

0.479

High

1247090

NEB2
Neurabin-2

1

2

High-throughput

0.479

High

1260677

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

1260682

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.479

High

1260683

UNC5B
Netrin receptor UNC5B

1

2

Small-scale

0.479

High

1260684

DPPA3
Developmental pluripotency-associated protein 3

1

1

Small-scale

0.479

High

1260685

EED
Polycomb protein EED

1

14

High-throughput

0.479

High

1260686

CHIP
E3 ubiquitin-protein ligase CHIP

1

11

Small-scale

0.479

High

1021549

ADCY8
Adenylate cyclase type 8

1

0

Small-scale

0.458

High

1242564

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

Small-scale

0.458

High

651547

CBL
E3 ubiquitin-protein ligase CBL

1

2

High-throughput

0.445

High

777937

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.445

High

915641

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.445

High

1193788

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.445

High

1260687

HDAC5
Histone deacetylase 5

1

14

High-throughput

0.445

High

60470

FXL16
F-box/LRR-repeat protein 16

1

2

Small-scale

0.437

High

611455

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

10

Small-scale

0.437

High

1260680

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.437

High

1260681

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.437

High

569641

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.426

High

905880

CAV3
Caveolin-3

1

2

High-throughput

0.407

High

1222587

IGBP1
Immunoglobulin-binding protein 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025