Protein: AP2A2
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)

Gene: AP2A2
Organism: Homo sapiens
Interactions: 176
UniProt ID: O94973

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0008289 - lipid binding
GO:0009898 - cytoplasmic side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

302192

AP2M1
AP-2 complex subunit mu

5

20

High-throughput

0.932

High

302215

NECP2
Adaptin ear-binding coat-associated protein 2

4

12

High-throughput

0.903

High

302125

AP2S1
AP-2 complex subunit sigma

3

20

High-throughput

0.871

High

302132

AP2B1
AP-2 complex subunit beta

3

15

High-throughput

0.861

High

302138

CLH1
Clathrin heavy chain 1

3

9

Small-scale

0.854

High

302078

EGFR
Epidermal growth factor receptor

6

13

Small-scale

0.736

High

302103

SHC1
SHC-transforming protein 1

5

17

Small-scale

0.720

High

302112

EPS15
Epidermal growth factor receptor substrate 15

5

20

Small-scale

0.717

High

302173

AAGAB
Alpha- and gamma-adaptin-binding protein p34

5

3

High-throughput

0.717

High

302144

AP1B1
AP-1 complex subunit beta-1

1

13

High-throughput

0.691

High

302186

NECP1
Adaptin ear-binding coat-associated protein 1

1

12

High-throughput

0.691

High

302118

AMPH
Amphiphysin

3

20

Small-scale

0.670

High

302091

CLCB
Clathrin light chain B

3

13

High-throughput

0.667

High

302148

EPN4
Clathrin interactor 1

2

20

High-throughput

0.628

High

302180

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.628

High

302185

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

12

High-throughput

0.628

High

302188

GP156
Probable G-protein coupled receptor 156

2

2

High-throughput

0.628

High

302229

SNX9
Sorting nexin-9

2

6

High-throughput

0.628

High

302095

TAU
Microtubule-associated protein tau

3

16

Small-scale

0.624

High

302075

AP2A1
AP-2 complex subunit alpha-1

1

15

High-throughput

0.618

High

302090

CLCA
Clathrin light chain A

2

15

High-throughput

0.611

High

302179

ZBT46
Zinc finger and BTB domain-containing protein 46

3

5

High-throughput

0.609

High

302094

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

18

High-throughput

0.602

High

302140

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

11

High-throughput

0.601

High

150794

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

7

Small-scale

0.584

High

302137

DAB2
Disabled homolog 2

2

20

Small-scale

0.584

High

302224

MYO6
Unconventional myosin-VI

2

6

Small-scale

0.584

High

302113

HD
Huntingtin

2

7

Small-scale

0.576

High

302164

RUN3A
RUN domain-containing protein 3A

2

5

High-throughput

0.574

High

302210

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.574

High

302116

PAXI
Paxillin

2

3

High-throughput

0.571

High

302141

KPCZ
Protein kinase C zeta type

2

4

High-throughput

0.571

High

302157

ITSN1
Intersectin-1

2

20

High-throughput

0.571

High

302230

EPN1
Epsin-1

1

20

Small-scale

0.561

High

147137

FCHO1
F-BAR domain only protein 1

1

10

High-throughput

0.536

High

161600

GAK
Cyclin-G-associated kinase

1

17

High-throughput

0.536

High

166867

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

2

High-throughput

0.536

High

302081

FINC
Fibronectin

1

4

High-throughput

0.536

High

302100

COMT
Catechol O-methyltransferase

1

3

High-throughput

0.536

High

302104

ARRB2
Beta-arrestin-2

1

8

High-throughput

0.536

High

302114

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.536

High

302115

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

302124

KIF11
Kinesin-like protein KIF11

1

6

High-throughput

0.536

High

302142

CALD1
Caldesmon

1

17

High-throughput

0.536

High

302152

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.536

High

302153

RBP1
RalA-binding protein 1

1

10

High-throughput

0.536

High

302193

REPS1
RalBP1-associated Eps domain-containing protein 1

1

20

High-throughput

0.536

High

302199

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

16

High-throughput

0.536

High

302203

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.536

High

302204

WNK3
Serine/threonine-protein kinase WNK3

1

8

High-throughput

0.536

High

302218

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.536

High

302221

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

20

High-throughput

0.536

High

302223

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

302098

RFA2
Replication protein A 32 kDa subunit

2

6

High-throughput

0.533

High

302102

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.533

High

302108

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.533

High

302082

TFR1
Transferrin receptor protein 1

1

4

High-throughput

0.515

High

302227

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.513

High

302156

SMAD1
Mothers against decapentaplegic homolog 1

1

2

High-throughput

0.508

High

302088

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

302216

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

4

Small-scale

0.501

High

302101

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

4

High-throughput

0.489

High

302135

M3K9
Mitogen-activated protein kinase kinase kinase 9

1

5

High-throughput

0.489

High

302158

DREB
Drebrin

1

7

High-throughput

0.489

High

302161

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

302178

LYRIC
Protein LYRIC

1

2

High-throughput

0.489

High

302189

ZCH10
Zinc finger CCHC domain-containing protein 10

1

3

High-throughput

0.489

High

302194

INT4
Integrator complex subunit 4

1

1

High-throughput

0.489

High

302200

CCD32
Coiled-coil domain-containing protein 32

1

1

High-throughput

0.489

High

302208

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

302220

NLGN3
Neuroligin-3

1

0

Small-scale

0.486

High

129627

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.479

High

131185

BIN1
Myc box-dependent-interacting protein 1

1

20

Small-scale

0.479

High

148239

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

167787

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

204859

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

209552

PRC1
Protein regulator of cytokinesis 1

1

10

High-throughput

0.479

High

212699

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

231365

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

3

Small-scale

0.479

High

262340

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

302074

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

302076

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

302079

CAH2
Carbonic anhydrase 2

1

1

High-throughput

0.479

High

302083

ESR1
Estrogen receptor

1

11

Small-scale

0.479

High

302084

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

302086

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

302087

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.479

High

302089

ISG15
Ubiquitin-like protein ISG15

1

18

High-throughput

0.479

High

302092

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

302093

FURIN
Furin

1

2

High-throughput

0.479

High

302096

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

302097

IFM1
Interferon-induced transmembrane protein 1

1

8

High-throughput

0.479

High

302099

RHOQ
Rho-related GTP-binding protein RhoQ

1

10

High-throughput

0.479

High

302105

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.479

High

302109

BASI
Basigin

1

5

High-throughput

0.479

High

302110

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

302121

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.479

High

302122

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

302123

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

High-throughput

0.479

High

302126

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

302127

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

302128

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

302129

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

302130

GRB2
Growth factor receptor-bound protein 2

1

17

Small-scale

0.479

High

302131

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

302133

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.479

High

302139

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

302143

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

302145

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

302149

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

302150

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

302151

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

302154

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.479

High

302159

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

302160

AAK1
AP2-associated protein kinase 1

1

19

High-throughput

0.479

High

302163

MIDN
Midnolin

1

2

High-throughput

0.479

High

302165

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

15

High-throughput

0.479

High

302171

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

302174

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

2

High-throughput

0.479

High

302175

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

302181

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.479

High

302182

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.479

High

302183

RHG18
Rho GTPase-activating protein 18

1

8

High-throughput

0.479

High

302184

FBXW8
F-box/WD repeat-containing protein 8

1

5

High-throughput

0.479

High

302187

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

13

High-throughput

0.479

High

302190

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

302201

RN126
E3 ubiquitin-protein ligase RNF126

1

3

High-throughput

0.479

High

302202

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

302206

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

Small-scale

0.479

High

302207

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

302212

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

302213

ANLN
Anillin

1

3

High-throughput

0.479

High

302217

MTMR4
Myotubularin-related protein 4

1

4

High-throughput

0.479

High

302219

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

302222

HDAC6
Histone deacetylase 6

1

4

High-throughput

0.479

High

302225

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.479

High

302107

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

302162

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

239666

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

302106

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

302120

NUMB
Protein numb homolog

1

20

Small-scale

0.445

High

302136

RHOG
Rho-related GTP-binding protein RhoG

1

9

Small-scale

0.445

High

302166

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

302172

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.445

High

302196

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

2

High-throughput

0.445

High

302205

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

132392

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

233122

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

294221

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.437

High

302073

HEXI1
Protein HEXIM1

1

5

High-throughput

0.437

High

302077

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

302080

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

302111

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.437

High

302117

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

302119

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.437

High

302134

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

302168

RC3H1
Roquin-1

1

5

High-throughput

0.437

High

302169

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

5

Small-scale

0.437

High

302170

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

2

High-throughput

0.437

High

302176

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

302177

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

302191

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

302195

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

302197

KCD15
BTB/POZ domain-containing protein KCTD15

1

1

Small-scale

0.437

High

302209

RC3H2
Roquin-2

1

12

High-throughput

0.437

High

302211

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.437

High

302214

BMP2K
BMP-2-inducible protein kinase

1

17

High-throughput

0.437

High

302226

RNF6
E3 ubiquitin-protein ligase RNF6

1

6

High-throughput

0.437

High

302146

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.426

High

302147

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.407

High

302167

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

302198

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

302085

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

64093

CPS4L
Putative cleavage and polyadenylation specificity factor subunit 4-like protein

1

0

High-throughput

0.279

Low

302228

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

302155

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024