HitPredict

Interactor 1: MAVS (Q8VCF0)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: SMUF1 (Q9CUN6)
E3 ubiquitin-protein ligase SMURF1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: Smurf1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23087404
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0051607 - defense response to virus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 503 Mm			1 731
+	Hs
		1278115 MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30		SMUF1_HUMAN (1-731): 0: 833: 95.24
+	Hs
		1278112 MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30		SMUF2_HUMAN (1-731): 0: 773: 73.60
+	Mm
		1298170 MAVS_MOUSE (1-503): 7.43e-63: 215: 100.00		ITCH_MOUSE (1-731): 0: 712: 32.38
+	Sc
		808390 SEC31_YEAST (95-474): 1.04e-27: 119: 13.63		TOM1_YEAST (316-730): 4.71e-153: 494: 38.61
+	Hs
		1278075 MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30		ITCH_HUMAN (1-395): 1.07e-29: 128: 16.03
+	Hs
		1326429 MINK1_HUMAN (84-393): 6.85e-25: 111: 13.78		NED4L_HUMAN (6-353): 1.65e-32: 137: 13.80
+	Hs
		131975 IF4G1_HUMAN (78-500): 1.34e-21: 101: 12.67		WWP2_HUMAN (1-410): 1.64e-31: 133: 15.72
+	Hs
		131851 SC24C_HUMAN (95-481): 4.08e-20: 96.4: 11.17		WWP2_HUMAN (1-410): 1.64e-31: 133: 15.72
+	Hs
		590343 MUC1_HUMAN (94-493): 2.32e-16: 84.4: 11.46		WWP1_HUMAN (2-376): 7.14e-25: 112: 15.84
+	Hs
		1253879 SRCAP_HUMAN (25-495): 1.76e-11: 69: 10.81		HECW2_HUMAN (85-375): 5.33e-14: 78.3: 11.34
+	Hs
		1395221 CHAP1_HUMAN (145-496): 2.87e-10: 64.8: 9.38		HECW2_HUMAN (85-375): 5.33e-14: 78.3: 11.34