Protein: SAMD1
Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)

Gene: SAMD1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q6SPF0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1247619

LMBL3
Lethal(3)malignant brain tumor-like protein 3

5

8

High-throughput

0.936

High

140319

SDCB1
Syntenin-1

1

3

High-throughput

0.691

High

1218276

SMBT2
Scm-like with four MBT domains protein 2

1

13

High-throughput

0.691

High

1247617

SCMH1
Polycomb protein SCMH1

1

8

High-throughput

0.691

High

1247642

SMBT1
Scm-like with four MBT domains protein 1

1

8

High-throughput

0.691

High

938110

ANM2
Protein arginine N-methyltransferase 2

4

4

High-throughput

0.691

High

1247600

DPPA4
Developmental pluripotency-associated protein 4

3

2

High-throughput

0.667

High

1247627

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

0

High-throughput

0.638

High

1101843

SKP2
S-phase kinase-associated protein 2

2

3

High-throughput

0.628

High

1128907

I13R2
Interleukin-13 receptor subunit alpha-2

2

3

High-throughput

0.628

High

774437

BASI
Basigin

3

4

High-throughput

0.609

High

246694

KDM1A
Lysine-specific histone demethylase 1A

2

6

High-throughput

0.584

High

1247603

FAM9B
Protein FAM9B

2

0

High-throughput

0.576

High

1060885

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

1

High-throughput

0.574

High

1092982

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.574

High

1247646

PCDGG
Protocadherin gamma-B4

2

2

High-throughput

0.574

High

1247651

PCDBB
Protocadherin beta-11

2

1

High-throughput

0.574

High

396355

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1247635

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.558

High

1219224

SAM13
Sterile alpha motif domain-containing protein 13

1

7

High-throughput

0.553

High

391305

FRIL
Ferritin light chain

2

2

High-throughput

0.549

High

899982

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.541

High

74524

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

156638

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

8

High-throughput

0.536

High

158457

RFXK
DNA-binding protein RFXANK

1

9

High-throughput

0.536

High

269248

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.536

High

276479

PDCD6
Programmed cell death protein 6

1

4

High-throughput

0.536

High

321845

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.536

High

682524

S100P
Protein S100-P

1

3

High-throughput

0.536

High

854122

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.536

High

1022735

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

High-throughput

0.536

High

1027537

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

High-throughput

0.536

High

1036752

DSG1
Desmoglein-1

1

3

High-throughput

0.536

High

1041765

PPARD
Peroxisome proliferator-activated receptor delta

1

16

High-throughput

0.536

High

1121255

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.536

High

1163001

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1247613

RENT1
Regulator of nonsense transcripts 1

1

3

High-throughput

0.536

High

1247614

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1247624

IWS1
Protein IWS1 homolog

1

7

High-throughput

0.536

High

1247626

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.536

High

1247632

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1247636

ECT2
Protein ECT2

1

7

High-throughput

0.536

High

1247647

TRI35
E3 ubiquitin-protein ligase TRIM35

1

2

High-throughput

0.536

High

1247602

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

5

High-throughput

0.514

High

282988

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.513

High

549333

SRF
Serum response factor

1

0

High-throughput

0.513

High

683730

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.513

High

1101358

SG2A2
Mammaglobin-A

1

0

High-throughput

0.513

High

1180922

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.513

High

1247604

EID3
EP300-interacting inhibitor of differentiation 3

1

0

High-throughput

0.513

High

1247608

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.513

High

1247621

NSE2
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.513

High

1247628

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

166164

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.489

High

630301

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

5

High-throughput

0.489

High

706177

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

880162

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

1150869

CIP4
Cdc42-interacting protein 4

1

3

High-throughput

0.489

High

1228666

C102B
Coiled-coil domain-containing protein 102B

1

5

High-throughput

0.489

High

1247609

PUM2
Pumilio homolog 2

1

3

High-throughput

0.489

High

1247611

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

High-throughput

0.489

High

1247623

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.489

High

1247630

CAD23
Cadherin-23

1

1

High-throughput

0.489

High

1247638

MYOF
Myoferlin

1

2

High-throughput

0.489

High

1247650

TLN1
Talin-1

1

9

High-throughput

0.489

High

1247652

PCDAA
Protocadherin alpha-10

1

2

High-throughput

0.489

High

129197

MEN1
Menin

1

5

High-throughput

0.479

High

174536

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.479

High

639760

TAF1
Transcription initiation factor TFIID subunit 1

1

18

High-throughput

0.479

High

979857

H4
Histone H4

1

5

High-throughput

0.479

High

998458

H31
Histone H3.1

1

15

High-throughput

0.479

High

1016964

H33
Histone H3.3

1

15

High-throughput

0.479

High

1054728

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

1095267

REST
RE1-silencing transcription factor

1

1

High-throughput

0.479

High

1113450

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1140445

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1247612

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1247616

PF21A
PHD finger protein 21A

1

13

High-throughput

0.479

High

1247620

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1247629

BRD8
Bromodomain-containing protein 8

1

15

High-throughput

0.479

High

1247641

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1247643

RCOR1
REST corepressor 1

1

4

High-throughput

0.479

High

1247645

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

12

Small-scale

0.479

High

1247625

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

679354

DNJB2
DnaJ homolog subfamily B member 2

1

5

High-throughput

0.445

High

1232366

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.445

High

1247637

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

106130

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

596996

TSHR
Thyrotropin receptor

1

3

High-throughput

0.437

High

675063

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.437

High

1137790

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.437

High

1247615

SH3K1
SH3 domain-containing kinase-binding protein 1

1

17

High-throughput

0.437

High

1247633

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

1247639

RCOR3
REST corepressor 3

1

4

High-throughput

0.437

High

1247640

HECW2
E3 ubiquitin-protein ligase HECW2

1

14

High-throughput

0.437

High

1247644

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.437

High

1247648

HIG1A
HIG1 domain family member 1A, mitochondrial

1

1

High-throughput

0.437

High

1181383

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1198579

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

58844

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

91637

C9JAW5
HIG1 domain-containing protein

1

1

High-throughput

0.407

High

94317

D6R9G5
Kelch like family member 2

1

2

High-throughput

0.407

High

627536

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

0

High-throughput

0.347

High

139397

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.328

High

1211424

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

342592

LY86
Lymphocyte antigen 86

2

0

High-throughput

0.313

High

1247622

TMM74
Transmembrane protein 74

2

0

High-throughput

0.313

High

1247653

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

0

High-throughput

0.313

High

140966

NOP56
Nucleolar protein 56

1

0

High-throughput

0.279

Low

162214

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.279

Low

223625

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

567007

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

692725

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

907804

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.279

Low

1238305

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.279

Low

1247601

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.279

Low

1247605

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1247606

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1247610

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.279

Low

1247618

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

1247634

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1247649

R3HC1
R3H and coiled-coil domain-containing protein 1

1

0

High-throughput

0.279

Low

329076

KLHL2
Kelch-like protein 2

1

0

High-throughput

0.249

Low

1247631

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1239224

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1247607

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025