HitPredict

Interactor 1: CDK1 (P23572)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: Q9VHN1 (Q9VHN1)
Cyclin-dependent kinases regulatory subunit
Gene: Cks85A

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.80	0.816

Property	Details
Experiments	15575970, 22036573, 21827746, 16603075, 38944040
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Dm			1 96
+	Hs
		667697 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CKS1_HUMAN (1-72): 3.81e-40: 129: 70.83
+	Hs
		667577 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CKS2_HUMAN (1-72): 1.11e-38: 125: 68.06
+	Dm
		660468 CDK2_DROME (1-291): 8.77e-134: 383: 56.70		Q9VHN1_DROME (1-96): 1.43e-58: 176: 100.00
+	Hs
		956646 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CKS1_HUMAN (1-72): 3.81e-40: 129: 70.83
+	Hs
		753913 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CKS2_HUMAN (1-72): 1.11e-38: 125: 68.06
+	Hs
		443287 CDK1_HUMAN (1-292): 4.2e-146: 413: 72.95		CKS1_HUMAN (1-72): 3.81e-40: 129: 70.83
+	Hs
		443221 CDK1_HUMAN (1-292): 4.2e-146: 413: 72.95		CKS2_HUMAN (1-72): 1.11e-38: 125: 68.06
+	Dm
		660384 CDK1_DROME (1-297): 6.19e-144: 408: 100.00		CKS1_DROME (3-73): 1.95e-39: 127: 64.79
+	At
		200085 CDKA1_ARATH (1-290): 9.37e-143: 405: 63.23		CKS1_ARATH (5-72): 6.83e-39: 126: 72.06
+	At
		663937 CDKA1_ARATH (1-290): 9.37e-143: 405: 63.23		CKS2_ARATH (5-72): 1.45e-37: 122: 67.65
+	Hs
		956647 CDK5_HUMAN (1-293): 1.69e-138: 394: 55.78		CKS1_HUMAN (1-72): 3.81e-40: 129: 70.83
+	Hs
		753914 CDK5_HUMAN (1-293): 1.69e-138: 394: 55.78		CKS2_HUMAN (1-72): 1.11e-38: 125: 68.06
+	Ce
		759628 CDK1_CAEEL (1-295): 4.28e-133: 381: 63.58		CKS1_CAEEL (3-72): 2.23e-40: 130: 61.43
+	Dm
		660434 CDK2_DROME (1-291): 8.77e-134: 383: 56.70		CKS1_DROME (3-73): 1.95e-39: 127: 64.79
+	Sp
		410432 CDK1_SCHPO (1-291): 8.84e-138: 392: 60.94		CKS1_SCHPO (4-73): 9.22e-35: 116: 46.84
+	At
		200096 CKB12_ARATH (1-294): 2.73e-132: 379: 50.80		CKS1_ARATH (5-72): 6.83e-39: 126: 72.06
+	At
		200112 CDKD2_ARATH (1-294): 1.01e-130: 376: 42.18		CKS1_ARATH (5-72): 6.83e-39: 126: 72.06
+	At
		1180621 CKB12_ARATH (1-294): 2.73e-132: 379: 50.80		CKS2_ARATH (5-72): 1.45e-37: 122: 67.65
+	At
		1423230 CDKD1_ARATH (2-295): 1.31e-130: 378: 43.20		CKS2_ARATH (5-72): 1.45e-37: 122: 67.65
+	Sc
		364323 CDK1_YEAST (1-289): 2.15e-133: 381: 58.02		CKS1_YEAST (4-72): 4.22e-34: 116: 50.00