Protein: RPGF1
Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)

Gene: RPGF1, RAPGEF1
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q13905

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982077

RAP1A
Ras-related protein Rap-1A

2

20

Small-scale

0.778

High

855618

CRK
Adapter molecule crk

15

20

Small-scale

0.763

High

855869

CRKL
Crk-like protein

16

20

Small-scale

0.762

High

942602

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

Small-scale

0.740

High

987624

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.705

High

363263

EGFR
Epidermal growth factor receptor

3

10

High-throughput

0.664

High

959440

RAP2B
Ras-related protein Rap-2b

1

20

Small-scale

0.647

High

362287

ABL1
Tyrosine-protein kinase ABL1

2

14

Small-scale

0.641

High

374590

RASH
GTPase HRas

1

20

High-throughput

0.618

High

953437

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.618

High

988354

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.618

High

1015427

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.618

High

1119089

CASL
Enhancer of filamentation 1

1

5

Small-scale

0.618

High

596481

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

Small-scale

0.586

High

651320

CBL
E3 ubiquitin-protein ligase CBL

2

6

Small-scale

0.584

High

473415

HCK
Tyrosine-protein kinase HCK

1

14

Small-scale

0.573

High

927288

ATX1
Ataxin-1

1

1

High-throughput

0.541

High

982431

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.541

High

1090127

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.536

High

1119091

MINK1
Misshapen-like kinase 1

1

3

High-throughput

0.536

High

1119096

FBW1B
F-box/WD repeat-containing protein 11

1

3

High-throughput

0.536

High

1119097

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.536

High

1119092

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.518

High

1119094

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.518

High

1119093

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.513

High

1119095

SPS2L
SPATS2-like protein

1

0

High-throughput

0.513

High

241640

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

440548

FYN
Tyrosine-protein kinase Fyn

1

14

High-throughput

0.479

High

557292

SRC
Proto-oncogene tyrosine-protein kinase Src

1

14

High-throughput

0.479

High

593989

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

699741

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.479

High

711347

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

1119090

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

837610

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025