Protein: NEP
Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)

Gene: NEP, MME
Organism: Homo sapiens
Interactions: 137
UniProt ID: P08473

Gene Ontology (top 5):
GO:0001786 - phosphatidylserine binding
GO:0001822 - kidney development
GO:0001890 - placenta development
GO:0002003 - angiotensin maturation
GO:0004175 - endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

470273

EPHB4
Ephrin type-B receptor 4

2

2

High-throughput

0.628

High

470323

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

1

High-throughput

0.628

High

470351

TEN3
Teneurin-3

2

3

High-throughput

0.628

High

470354

MAN1
Inner nuclear membrane protein Man1

2

2

High-throughput

0.628

High

249410

ACSL4
Long-chain-fatty-acid--CoA ligase 4

2

0

High-throughput

0.602

High

470254

B4GT1
Beta-1,4-galactosyltransferase 1

2

0

High-throughput

0.602

High

470290

NTCP7
Sodium/bile acid cotransporter 7

2

0

High-throughput

0.602

High

470295

STAR3
StAR-related lipid transfer protein 3

2

0

High-throughput

0.602

High

470335

PXL2A
Peroxiredoxin-like 2A

2

0

High-throughput

0.602

High

470339

GL8D2
Glycosyltransferase 8 domain-containing protein 2

2

0

High-throughput

0.602

High

470347

PXMP2
Peroxisomal membrane protein 2

2

0

High-throughput

0.602

High

463283

LYN
Tyrosine-protein kinase Lyn

2

0

Small-scale

0.598

High

470283

CSK21
Casein kinase II subunit alpha

2

0

Small-scale

0.592

High

470244

NEP
Neprilysin

1

1

Small-scale

0.575

High

470306

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

1

High-throughput

0.574

High

470277

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.569

High

470250

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.536

High

470259

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

1

High-throughput

0.536

High

470262

ADDB
Beta-adducin

1

1

High-throughput

0.536

High

470263

LONM
Lon protease homolog, mitochondrial

1

1

Small-scale

0.536

High

470265

ARL1
ADP-ribosylation factor-like protein 1

1

1

Small-scale

0.536

High

470267

RS10
Small ribosomal subunit protein eS10

1

1

Small-scale

0.536

High

470271

MOT1
Monocarboxylate transporter 1

1

1

Small-scale

0.536

High

470278

RAP2B
Ras-related protein Rap-2b

1

3

Small-scale

0.536

High

470293

RBM39
RNA-binding protein 39

1

1

Small-scale

0.536

High

470296

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

Small-scale

0.536

High

470300

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

Small-scale

0.536

High

470307

LTOR1
Ragulator complex protein LAMTOR1

1

1

Small-scale

0.536

High

470311

GALT7
N-acetylgalactosaminyltransferase 7

1

2

High-throughput

0.536

High

470321

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.536

High

470328

S67A1
Solute carrier family 67 member A1

1

7

High-throughput

0.536

High

470334

CAB45
45 kDa calcium-binding protein

1

2

Small-scale

0.536

High

470336

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

470341

CLC4M
C-type lectin domain family 4 member M

1

3

Small-scale

0.536

High

470350

DJB12
DnaJ homolog subfamily B member 12

1

3

Small-scale

0.536

High

470352

RUVB2
RuvB-like 2

1

1

Small-scale

0.536

High

470353

RUVB1
RuvB-like 1

1

1

Small-scale

0.536

High

139090

FAAH1
Fatty-acid amide hydrolase 1

1

0

Small-scale

0.513

High

162769

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

Small-scale

0.513

High

186399

TM9S1
Transmembrane 9 superfamily member 1

1

0

Small-scale

0.513

High

210168

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

Small-scale

0.513

High

245408

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.513

High

295789

FACE1
CAAX prenyl protease 1 homolog

1

0

Small-scale

0.513

High

328289

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

Small-scale

0.513

High

333614

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

Small-scale

0.513

High

385378

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.513

High

415282

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.513

High

470245

H2A1
Histone H2A type 1

1

0

Small-scale

0.513

High

470248

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.513

High

470249

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.513

High

470251

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.513

High

470252

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.513

High

470253

K1C10
Keratin, type I cytoskeletal 10

1

0

Small-scale

0.513

High

470258

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.513

High

470261

MYH9
Myosin-9

1

0

Small-scale

0.513

High

470266

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

Small-scale

0.513

High

470268

UTRN
Utrophin

1

0

Small-scale

0.513

High

470269

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.513

High

470270

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

Small-scale

0.513

High

470272

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

Small-scale

0.513

High

470279

RS23
Small ribosomal subunit protein uS12

1

0

Small-scale

0.513

High

470281

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.513

High

470282

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.513

High

470286

FOLH1
Glutamate carboxypeptidase 2

1

0

Small-scale

0.513

High

470288

SRS11
Serine/arginine-rich splicing factor 11

1

0

Small-scale

0.513

High

470291

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

Small-scale

0.513

High

470292

FLOT2
Flotillin-2

1

0

Small-scale

0.513

High

470302

TBB8
Tubulin beta-8 chain

1

0

Small-scale

0.513

High

470305

TM164
Transmembrane protein 164

1

0

High-throughput

0.513

High

470308

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

Small-scale

0.513

High

470313

LYRIC
Protein LYRIC

1

0

Small-scale

0.513

High

470314

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.513

High

470319

KBTB3
Kelch repeat and BTB domain-containing protein 3

1

0

Small-scale

0.513

High

470326

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.513

High

470327

TNPO1
Transportin-1

1

0

Small-scale

0.513

High

470329

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.513

High

470331

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.513

High

470337

HDAC8
Histone deacetylase 8

1

0

High-throughput

0.513

High

470338

F234A
Protein FAM234A

1

0

Small-scale

0.513

High

470340

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

Small-scale

0.513

High

470342

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

470343

TMT1A
Thiol S-methyltransferase TMT1A

1

0

Small-scale

0.513

High

470345

RM44
Large ribosomal subunit protein mL44

1

0

Small-scale

0.513

High

369532

ANGT
Angiotensinogen

1

2

Small-scale

0.501

High

470255

EZRI
Ezrin

1

2

Small-scale

0.501

High

470257

CD9
CD9 antigen

1

8

Small-scale

0.500

High

470324

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

421341

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

470289

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

470294

PDIA5
Protein disulfide-isomerase A5

1

4

Small-scale

0.489

High

470304

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.489

High

376968

ANF
Natriuretic peptides A

1

0

Small-scale

0.480

High

470246

POTEI
POTE ankyrin domain family member I

1

1

Small-scale

0.479

High

470247

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

470260

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

470275

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.479

High

470280

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

470287

FAK1
Focal adhesion kinase 1

1

2

Small-scale

0.479

High

470298

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

470299

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

470310

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

470316

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

470325

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

470332

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

1

Small-scale

0.479

High

470264

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

470297

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

270615

ATP9A
Probable phospholipid-transporting ATPase IIA

1

0

High-throughput

0.458

High

378815

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

470285

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

470303

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

470318

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

470344

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

470346

ANLN
Anillin

1

0

High-throughput

0.458

High

380514

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

9

Small-scale

0.445

High

409226

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.445

High

470256

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

3

Small-scale

0.445

High

470276

CD81
CD81 antigen

1

8

Small-scale

0.445

High

470317

CD177
CD177 antigen

1

1

Small-scale

0.445

High

465991

ANXA6
Annexin A6

1

0

Small-scale

0.426

High

470356

DAAM1
Disheveled-associated activator of morphogenesis 1

1

0

Small-scale

0.426

High

470309

POTEH
POTE ankyrin domain family member H

1

1

Small-scale

0.407

High

49429

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

470274

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

Small-scale

0.279

Low

470284

RT25
Small ribosomal subunit protein mS25

1

0

Small-scale

0.279

Low

470301

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

Small-scale

0.279

Low

470315

ARM10
Armadillo repeat-containing protein 10

1

0

Small-scale

0.279

Low

470320

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

Small-scale

0.279

Low

470322

FA83F
Protein FAM83F

1

0

Small-scale

0.279

Low

470355

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.279

Low

470357

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

Small-scale

0.279

Low

470348

SNRK
SNF-related serine/threonine-protein kinase

1

0

High-throughput

0.269

Low

105156

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

470312

NOP9
Nucleolar protein 9

1

0

Small-scale

0.232

Low

470330

GUCD1
Protein GUCD1

1

0

Small-scale

0.232

Low

470333

CMS1
Protein CMSS1

1

0

Small-scale

0.232

Low

470349

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025