Protein: GDS1
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)

Gene: GDS1, RAP1GDS1
Organism: Homo sapiens
Interactions: 122
UniProt ID: P52306

Gene Ontology (top 5):
GO:0003300 - cardiac muscle hypertrophy
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

911824

RAC1
Ras-related C3 botulinum toxin substrate 1

10

6

Small-scale

0.975

High

911818

RHOA
Transforming protein RhoA

10

7

Small-scale

0.974

High

374484

RASH
GTPase HRas

5

8

Small-scale

0.934

High

911895

RAP2C
Ras-related protein Rap-2c

5

12

High-throughput

0.924

High

911822

RAP1A
Ras-related protein Rap-1A

4

10

Small-scale

0.902

High

466165

RHOC
Rho-related GTP-binding protein RhoC

4

7

High-throughput

0.900

High

520680

RRAS
Ras-related protein R-Ras

4

11

High-throughput

0.890

High

911820

RRAS2
Ras-related protein R-Ras2

4

8

High-throughput

0.890

High

911878

RAB6B
Ras-related protein Rab-6B

4

3

High-throughput

0.890

High

911815

CDC42
Cell division control protein 42 homolog

4

6

High-throughput

0.888

High

373851

RASN
GTPase NRas

4

8

Small-scale

0.885

High

375313

RASK
GTPase KRas

3

7

Small-scale

0.858

High

911813

RAB15
Ras-related protein Rab-15

3

1

High-throughput

0.855

High

911816

RAP1B
Ras-related protein Rap-1b

3

10

High-throughput

0.855

High

911876

RHOF
Rho-related GTP-binding protein RhoF

3

8

High-throughput

0.855

High

911871

RAB34
Ras-related protein Rab-34

3

4

High-throughput

0.847

High

911831

RAB31
Ras-related protein Rab-31

3

1

High-throughput

0.839

High

325393

DIRA1
GTP-binding protein Di-Ras1

5

14

High-throughput

0.826

High

911859

DIRA2
GTP-binding protein Di-Ras2

5

12

High-throughput

0.826

High

580944

RAC2
Ras-related C3 botulinum toxin substrate 2

2

6

High-throughput

0.811

High

911814

RAC3
Ras-related C3 botulinum toxin substrate 3

2

6

High-throughput

0.811

High

604622

UBF1
Nucleolar transcription factor 1

3

0

High-throughput

0.811

High

539872

RALB
Ras-related protein Ral-B

3

11

High-throughput

0.805

High

911817

RAP2B
Ras-related protein Rap-2b

2

12

High-throughput

0.783

High

518586

RAP2A
Ras-related protein Rap-2a

2

13

High-throughput

0.776

High

911853

RSLAA
Ras-like protein family member 10A

3

13

High-throughput

0.770

High

911872

RAB1B
Ras-related protein Rab-1B

2

0

High-throughput

0.748

High

911827

RHOG
Rho-related GTP-binding protein RhoG

2

6

High-throughput

0.737

High

911885

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

2

11

High-throughput

0.726

High

911883

RAB20
Ras-related protein Rab-20

2

2

High-throughput

0.694

High

911821

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.691

High

911855

APBB2
Amyloid beta precursor protein binding family B member 2

4

0

High-throughput

0.661

High

911896

T22D4
TSC22 domain family protein 4

4

0

High-throughput

0.661

High

911866

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

911812

ARL4C
ADP-ribosylation factor-like protein 4C

2

1

High-throughput

0.628

High

902242

RAB28
Ras-related protein Rab-28

1

2

High-throughput

0.618

High

911865

RSLBB
Ras-like protein family member 11B

1

6

High-throughput

0.618

High

911884

RASLC
Ras-like protein family member 12

1

10

High-throughput

0.618

High

911879

MBIP1
MAP3K12-binding inhibitory protein 1

2

0

High-throughput

0.618

High

911832

SEPT6
Septin-6

3

3

High-throughput

0.609

High

911851

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

2

0

High-throughput

0.602

High

911877

PRD10
PR domain zinc finger protein 10

2

0

High-throughput

0.602

High

911834

GNA13
Guanine nucleotide-binding protein subunit alpha-13

2

2

High-throughput

0.601

High

911892

BAIP2
BAR/IMD domain-containing adapter protein 2

2

0

High-throughput

0.585

High

363009

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

911842

RN19B
E3 ubiquitin-protein ligase RNF19B

2

0

High-throughput

0.580

High

631631

RAB6A
Ras-related protein Rab-6A

1

3

High-throughput

0.575

High

911870

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.575

High

911837

RABL3
Rab-like protein 3

2

2

High-throughput

0.574

High

341006

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.553

High

911858

RHES
GTP-binding protein Rhes

1

12

High-throughput

0.553

High

522622

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.529

High

911860

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

911897

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.518

High

165121

RASM
Ras-related protein M-Ras

1

9

High-throughput

0.514

High

529390

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

667671

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.513

High

793679

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.513

High

842693

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

911823

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

911844

VASH1
Tubulinyl-Tyr carboxypeptidase 1

1

0

High-throughput

0.513

High

911863

CEP89
Centrosomal protein of 89 kDa

1

0

High-throughput

0.513

High

911868

RBM42
RNA-binding protein 42

1

0

High-throughput

0.513

High

911873

GBA3
Cytosolic beta-glucosidase

1

0

High-throughput

0.513

High

911874

RABE2
Rab GTPase-binding effector protein 2

1

0

High-throughput

0.513

High

911887

CRNN
Cornulin

1

0

High-throughput

0.513

High

911891

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

0

High-throughput

0.513

High

911854

KIFA3
Kinesin-associated protein 3

1

0

Small-scale

0.504

High

185546

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

698509

CALX
Calnexin

1

0

High-throughput

0.493

High

911882

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.493

High

911857

OPTN
Optineurin

1

0

High-throughput

0.493

High

911826

I13R1
Interleukin-13 receptor subunit alpha-1

1

1

High-throughput

0.489

High

911829

ARL16
ADP-ribosylation factor-like protein 16

1

1

High-throughput

0.489

High

911875

IFT22
Intraflagellar transport protein 22 homolog

1

1

High-throughput

0.489

High

507708

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

728123

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

618445

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

2

High-throughput

0.479

High

911825

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

High-throughput

0.479

High

911847

SEP12
Septin-12

1

3

High-throughput

0.479

High

385581

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

411621

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

536798

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

582721

EZRI
Ezrin

1

0

High-throughput

0.458

High

764286

CTNA1
Catenin alpha-1

1

0

High-throughput

0.458

High

911811

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.458

High

911830

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

911838

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

911846

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

911849

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

911852

HDAC7
Histone deacetylase 7

1

0

High-throughput

0.458

High

911856

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

911869

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.458

High

884438

PCY1A
Choline-phosphate cytidylyltransferase A

1

1

High-throughput

0.445

High

911864

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.445

High

911898

PCY1B
Choline-phosphate cytidylyltransferase B

1

1

High-throughput

0.445

High

911819

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.438

High

911886

SEP10
Septin-10

1

3

High-throughput

0.437

High

238770

SSX4
Protein SSX4

1

0

High-throughput

0.426

High

911828

HEN2
Helix-loop-helix protein 2

1

0

High-throughput

0.426

High

911839

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

911845

SKAP1
Src kinase-associated phosphoprotein 1

1

0

High-throughput

0.426

High

911862

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

911893

RUVB1
RuvB-like 1

1

0

High-throughput

0.426

High

911881

SEP11
Septin-11

1

3

High-throughput

0.407

High

911888

PKHB1
Pleckstrin homology domain-containing family B member 1

5

0

High-throughput

0.378

High

911836

DNAL1
Dynein axonemal light chain 1

2

0

High-throughput

0.328

High

911840

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

911848

TTC9C
Tetratricopeptide repeat protein 9C

2

0

High-throughput

0.313

High

911833

DOC2A
Double C2-like domain-containing protein alpha

1

0

High-throughput

0.282

High

911835

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

911841

TMED8
Protein TMED8

1

0

High-throughput

0.279

Low

911850

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

0

High-throughput

0.279

Low

911889

S18L2
SS18-like protein 2

1

0

High-throughput

0.279

Low

911890

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.265

Low

105616

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

911843

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

911861

CB048
Putative uncharacterized protein C2orf48

1

0

High-throughput

0.249

Low

911867

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

911880

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

911894

SNX24
Sorting nexin-24

1

0

High-throughput

0.249

Low

515754

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025