Protein: SPCS3
Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)

Gene: SPCS3
Organism: Homo sapiens
Interactions: 130
UniProt ID: P61009

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

956103

SC11C
Signal peptidase complex catalytic subunit SEC11C

3

3

High-throughput

0.855

High

956044

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

3

High-throughput

0.776

High

956127

SPCS1
Signal peptidase complex subunit 1

2

0

High-throughput

0.736

High

698545

CALX
Calnexin

2

1

High-throughput

0.611

High

956054

SPCS2
Signal peptidase complex subunit 2

2

1

High-throughput

0.601

High

956038

RAP2B
Ras-related protein Rap-2b

2

1

High-throughput

0.549

High

956084

UBR2
E3 ubiquitin-protein ligase UBR2

2

1

High-throughput

0.549

High

130056

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

181294

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

332946

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.536

High

359962

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.536

High

534859

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

813054

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

956064

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.536

High

956116

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

395792

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

956046

HTRA3
Serine protease HTRA3

1

0

High-throughput

0.513

High

956051

OS9
Protein OS-9

1

0

High-throughput

0.513

High

956055

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

956058

LAMA3
Laminin subunit alpha-3

1

0

High-throughput

0.513

High

956061

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

956092

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

956102

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.513

High

956105

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.513

High

956108

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

956121

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.513

High

843440

HD
Huntingtin

1

0

High-throughput

0.493

High

956048

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.489

High

956076

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

1

High-throughput

0.489

High

956083

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.489

High

956112

RAB6B
Ras-related protein Rab-6B

1

1

High-throughput

0.489

High

956120

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.489

High

956124

RAP2C
Ras-related protein Rap-2c

1

1

High-throughput

0.489

High

466180

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

580964

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

611066

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

955006

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

956039

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

956043

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

956047

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

956086

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

956096

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

956097

CALR3
Calreticulin-3

1

1

High-throughput

0.479

High

956106

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

956118

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

178228

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

241255

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

566614

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.458

High

951048

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

956053

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

956063

MKS3
Meckelin

1

0

High-throughput

0.458

High

956071

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

956093

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

956110

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

631634

RAB6A
Ras-related protein Rab-6A

1

1

High-throughput

0.445

High

956100

MIA2
Melanoma inhibitory activity protein 2

1

1

High-throughput

0.445

High

126531

RHOD
Rho-related GTP-binding protein RhoD

1

7

High-throughput

0.437

High

403944

GCR
Glucocorticoid receptor

1

2

High-throughput

0.437

High

956045

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

956062

TECT1
Tectonic-1

1

2

High-throughput

0.437

High

956068

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

956081

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

956085

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.437

High

956090

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

956095

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

956107

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.437

High

956040

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.426

High

956057

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.426

High

956065

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.426

High

956066

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

927209

ATX1
Ataxin-1

2

0

High-throughput

0.324

High

277005

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

2

0

High-throughput

0.313

High

956056

LRC41
Leucine-rich repeat-containing protein 41

2

0

High-throughput

0.313

High

956067

DNLZ
DNL-type zinc finger protein

2

0

High-throughput

0.313

High

956122

S22AE
Solute carrier family 22 member 14

2

0

High-throughput

0.305

High

219944

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

253430

CST8
Cystatin-8

1

0

High-throughput

0.279

Low

409568

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

547121

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.279

Low

762285

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.279

Low

956041

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.279

Low

956042

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.279

Low

956052

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.279

Low

956070

CSPG4
Chondroitin sulfate proteoglycan 4

1

0

High-throughput

0.279

Low

956072

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

0

High-throughput

0.279

Low

956075

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.279

Low

956078

LRP11
Low-density lipoprotein receptor-related protein 11

1

0

High-throughput

0.279

Low

956079

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

956082

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

956087

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

956089

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.279

Low

956094

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

956099

SFXN2
Sideroflexin-2

1

0

High-throughput

0.279

Low

956101

NEUR1
Sialidase-1

1

0

High-throughput

0.279

Low

956104

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.279

Low

956111

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

956113

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

956119

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

956091

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.269

Low

218021

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

227455

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

293464

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

371614

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

400575

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

540383

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.249

Low

588353

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695084

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767842

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

887892

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

904521

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

956049

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

956059

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

956060

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.249

Low

956073

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

956074

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

956077

LBN
Limbin

1

0

High-throughput

0.249

Low

956080

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

956088

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

956098

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

956109

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

956114

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

956115

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

956117

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

956123

SF3B6
Splicing factor 3B subunit 6

1

0

High-throughput

0.249

Low

956125

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

529471

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

841126

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

956050

NMI
N-myc-interactor

1

0

High-throughput

0.232

Low

956069

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

0

High-throughput

0.232

Low

956126

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025