Protein: TYW4
tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase)

Gene: TYW4, LCMT2
Organism: Homo sapiens
Interactions: 26
UniProt ID: O60294

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0006400 - tRNA modification
GO:0008175 - tRNA methyltransferase activity
GO:0030488 - tRNA methylation
GO:0031591 - wybutosine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244822

DNJC7
DnaJ homolog subfamily C member 7

3

1

High-throughput

0.667

High

244809

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.602

High

244818

RN123
E3 ubiquitin-protein ligase RNF123

2

0

High-throughput

0.602

High

224554

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.549

High

244803

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.536

High

244807

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

244812

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

244815

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

244819

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

244821

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.513

High

244826

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

244825

DNJB4
DnaJ homolog subfamily B member 4

1

1

High-throughput

0.489

High

244820

CCNJL
Cyclin-J-like protein

1

1

High-throughput

0.479

High

244811

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

244817

FGL1
Fibrinogen-like protein 1

4

0

High-throughput

0.360

High

244810

TKT
Transketolase

2

0

High-throughput

0.328

High

244824

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.328

High

125818

AP4M1
AP-4 complex subunit mu-1

1

0

High-throughput

0.279

Low

244804

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.279

Low

244805

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.279

Low

244816

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.279

Low

244806

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

244808

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

244814

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

244813

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.232

Low

244823

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025