Protein: TCF25
Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25)

Gene: TCF25
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9BQ70

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0061945 - regulation of protein K48-linked ubiquitination
GO:0072344 - rescue of stalled ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1386947

GASP2
G-protein coupled receptor-associated sorting protein 2

8

1

High-throughput

0.754

High

639637

SAT1
Diamine acetyltransferase 1

7

0

High-throughput

0.720

High

848930

MAGAB
Melanoma-associated antigen 11

5

0

High-throughput

0.691

High

469830

CATG
Cathepsin G

4

0

High-throughput

0.661

High

1371641

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

2

High-throughput

0.628

High

1182859

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

1

High-throughput

0.602

High

1410186

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

1410191

SSF1
Suppressor of SWI4 1 homolog

2

0

High-throughput

0.602

High

1410197

SHPK
Sedoheptulokinase

2

0

High-throughput

0.602

High

329098

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

1209574

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

High-throughput

0.585

High

1395138

DCAF5
DDB1- and CUL4-associated factor 5

2

1

High-throughput

0.574

High

424675

KPCG
Protein kinase C gamma type

2

1

High-throughput

0.571

High

835739

KPCI
Protein kinase C iota type

2

1

High-throughput

0.571

High

1365967

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.549

High

193615

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

0

High-throughput

0.547

High

249777

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

631438

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

702372

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

1038347

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

0

High-throughput

0.547

High

1410198

AGO1
Protein argonaute-1

2

0

High-throughput

0.547

High

1410183

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.541

High

1022783

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

Small-scale

0.537

High

730195

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.536

High

966808

1433G
14-3-3 protein gamma

1

3

High-throughput

0.536

High

990664

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.536

High

1371516

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.536

High

66810

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

607711

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.513

High

800428

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.513

High

971934

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

1368293

STAM1
Signal transducing adapter molecule 1

1

0

High-throughput

0.513

High

1399706

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1405604

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

1410188

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

1410192

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.513

High

860912

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.508

High

908852

NEK2
Serine/threonine-protein kinase Nek2

1

0

High-throughput

0.486

High

1410193

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

2

Small-scale

0.481

High

951832

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

173280

XPO1
Exportin-1

1

2

High-throughput

0.479

High

242729

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

461872

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468740

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

586855

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

1116774

AAMP
Angio-associated migratory cell protein

1

1

High-throughput

0.479

High

1280446

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1322638

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

1410182

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

1410185

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

1410201

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

129373

MEN1
Menin

1

0

High-throughput

0.458

High

272420

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

279471

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

315944

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

589532

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696340

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

920237

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

937874

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

958182

ARP3
Actin-related protein 3

1

0

High-throughput

0.458

High

1045701

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1126643

GRB7
Growth factor receptor-bound protein 7

1

0

Small-scale

0.458

High

1135787

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1137987

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1178335

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1252954

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1367125

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1368090

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1380118

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1393636

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1410189

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1410190

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

1410194

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1410196

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1410199

BRPF3
Bromodomain and PHD finger-containing protein 3

1

0

High-throughput

0.458

High

944052

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1244641

GASP3
G protein-coupled receptor associated sorting protein 3

1

1

High-throughput

0.445

High

1410187

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

530293

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

946194

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.426

High

1149974

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.426

High

1258561

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1358188

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.426

High

94326

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

1065020

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

642108

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

2

0

High-throughput

0.328

High

1402859

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.316

High

1329435

KASH5
Protein KASH5

1

0

High-throughput

0.299

High

1410181

DERL1
Derlin-1

1

0

High-throughput

0.299

High

554828

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1260656

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

0

High-throughput

0.279

Low

1410195

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

246118

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

301660

WFS1
Wolframin

1

0

High-throughput

0.268

Low

643047

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

769014

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1249156

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1255263

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1410184

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

1410200

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

167463

WNT9A
Protein Wnt-9a

1

0

High-throughput

0.232

Low

244823

TYW4
tRNA wybutosine-synthesizing protein 4

1

0

High-throughput

0.232

Low

567967

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.232

Low

1235734

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

0

High-throughput

0.232

Low

1355966

NET5
Netrin-5

1

0

High-throughput

0.232

Low

1362049

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025