Protein: ZBED1
E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)

Gene: ZBED1
Organism: Homo sapiens
Interactions: 94
UniProt ID: O96006

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

354198

ZBED1
E3 SUMO-protein ligase ZBED1

4

12

Small-scale

0.898

High

354217

UBC9
SUMO-conjugating enzyme UBC9

4

4

Small-scale

0.694

High

354258

AIRIM
AFG2-interacting ribosome maturation factor

4

0

High-throughput

0.673

High

354204

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

4

0

High-throughput

0.669

High

354253

ZN576
Zinc finger protein 576

3

8

High-throughput

0.662

High

354229

EFHC1
EF-hand domain-containing protein 1

3

0

High-throughput

0.646

High

354203

TPC2B
Trafficking protein particle complex subunit 2B

3

1

High-throughput

0.642

High

354245

WDFY2
WD repeat and FYVE domain-containing protein 2

3

0

High-throughput

0.638

High

246374

KDM1A
Lysine-specific histone demethylase 1A

3

0

High-throughput

0.633

High

354265

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

1

High-throughput

0.628

High

354240

LRC20
Leucine-rich repeat-containing protein 20

3

1

High-throughput

0.616

High

191507

MAGB2
Melanoma-associated antigen B2

2

1

High-throughput

0.606

High

288324

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.606

High

354207

PAX6
Paired box protein Pax-6

2

3

High-throughput

0.606

High

354236

CCD13
Coiled-coil domain-containing protein 13

2

1

High-throughput

0.606

High

354238

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

1

High-throughput

0.606

High

354239

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.606

High

354242

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.606

High

185135

FANCG
Fanconi anemia group G protein

2

0

High-throughput

0.605

High

289206

CREG1
Protein CREG1

2

0

High-throughput

0.602

High

316715

MTA2
Metastasis-associated protein MTA2

2

0

High-throughput

0.602

High

352047

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.602

High

354212

CDK7
Cyclin-dependent kinase 7

2

0

High-throughput

0.602

High

354220

CSTF1
Cleavage stimulation factor subunit 1

2

0

High-throughput

0.602

High

354241

P66B
Transcriptional repressor p66-beta

2

0

High-throughput

0.602

High

354225

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

4

High-throughput

0.601

High

354221

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

Small-scale

0.586

High

180201

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

354214

DPOE2
DNA polymerase epsilon subunit 2

2

0

High-throughput

0.580

High

354247

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.580

High

354252

F124B
Protein FAM124B

2

0

High-throughput

0.580

High

354256

MKKS
Molecular chaperone MKKS

2

0

High-throughput

0.580

High

354263

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.580

High

243875

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

1

High-throughput

0.574

High

297725

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

High-throughput

0.573

High

354270

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

High-throughput

0.573

High

354211

ATRX
Transcriptional regulator ATRX

1

4

Small-scale

0.561

High

354234

Q7KZS0
SUMO-conjugating enzyme UBC9

2

4

High-throughput

0.558

High

354230

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

4

High-throughput

0.558

High

354223

RIN1
Ras and Rab interactor 1

2

2

High-throughput

0.553

High

354222

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.549

High

354226

SSX2
Protein SSX2

1

0

High-throughput

0.549

High

250194

VINEX
Vinexin

1

1

High-throughput

0.541

High

354200

S100B
Protein S100-B

1

3

High-throughput

0.536

High

354208

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

354210

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.518

High

354251

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.518

High

354255

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.518

High

354266

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.518

High

354202

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.515

High

354215

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

354216

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.501

High

354235

GPSM1
G-protein-signaling modulator 1

1

1

High-throughput

0.494

High

162762

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

4

High-throughput

0.489

High

354209

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

354205

FABP4
Fatty acid-binding protein, adipocyte

1

0

High-throughput

0.486

High

129631

CBX4
E3 SUMO-protein ligase CBX4

1

1

Small-scale

0.481

High

297386

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.481

High

354224

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

354246

RANB9
Ran-binding protein 9

1

2

Small-scale

0.481

High

354264

ZHX1
Zinc fingers and homeoboxes protein 1

1

1

Small-scale

0.481

High

69641

A8K5H9
cDNA FLJ76839, highly similar to Homo sapiens kelch repeat and BTB

1

2

High-throughput

0.470

High

339126

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

Small-scale

0.460

High

354268

ZN451
E3 SUMO-protein ligase ZNF451

1

0

Small-scale

0.460

High

279259

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

354262

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

354228

KLH40
Kelch-like protein 40

1

2

High-throughput

0.439

High

354219

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.437

High

354244

SNX27
Sorting nexin-27

1

4

High-throughput

0.437

High

354232

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.426

High

354271

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

71049

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

4

High-throughput

0.407

High

354201

SAP
Prosaposin

3

0

High-throughput

0.348

High

354237

DHRSX
Polyprenol dehydrogenase

3

0

High-throughput

0.342

High

354269

SPEF1
Sperm flagellar protein 1

2

0

High-throughput

0.330

High

354259

GDAP2
Ganglioside-induced differentiation-associated protein 2

2

0

High-throughput

0.328

High

354206

THTM
3-mercaptopyruvate sulfurtransferase

2

0

High-throughput

0.316

High

354218

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.316

High

354227

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.316

High

354231

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

354248

GGACT
Gamma-glutamylaminecyclotransferase

2

0

High-throughput

0.316

High

354249

FND11
Fibronectin type III domain-containing protein 11

2

0

High-throughput

0.316

High

354254

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

354257

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

354260

NCDN
Neurochondrin

2

0

High-throughput

0.316

High

354261

CTNL1
Alpha-catulin

2

0

High-throughput

0.316

High

354267

AMOL2
Angiomotin-like protein 2

1

0

High-throughput

0.299

High

354213

RENBP
N-acylglucosamine 2-epimerase

1

0

High-throughput

0.282

High

354233

NUD18
8-oxo-dGDP phosphatase NUDT18

1

0

High-throughput

0.282

High

244805

TYW4
tRNA wybutosine-synthesizing protein 4

1

0

High-throughput

0.279

Low

354250

LOXE3
Hydroperoxide isomerase ALOXE3

1

0

High-throughput

0.279

Low

354243

MY15B
Unconventional myosin-XVB

1

0

High-throughput

0.268

Low

354199

TTHY
Transthyretin

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025