Protein: CSK
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)

Gene: CSK
Organism: Homo sapiens
Interactions: 152
UniProt ID: P41240

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782829

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

9

11

Small-scale

0.975

High

782795

TENS2
Tensin-2

6

20

High-throughput

0.952

High

338069

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.925

High

782797

TENS3
Tensin-3

5

20

High-throughput

0.919

High

782751

FRK
Tyrosine-protein kinase FRK

3

19

High-throughput

0.871

High

782802

PRAG1
Inactive tyrosine-protein kinase PRAG1

3

4

Small-scale

0.853

High

782749

CSK
Tyrosine-protein kinase CSK

3

19

Small-scale

0.840

High

782767

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.839

High

522833

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.834

High

782750

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

19

High-throughput

0.811

High

666029

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.799

High

782811

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

20

High-throughput

0.789

High

782828

TENS1
Tensin-1

2

17

High-throughput

0.789

High

782794

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

5

High-throughput

0.783

High

441186

PTPRC
Receptor-type tyrosine-protein phosphatase C

2

20

Small-scale

0.778

High

182106

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

17

High-throughput

0.767

High

435570

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.766

High

226747

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

782777

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

20

High-throughput

0.754

High

782837

PTN22
Tyrosine-protein phosphatase non-receptor type 22

2

20

High-throughput

0.754

High

411626

LCK
Tyrosine-protein kinase Lck

2

18

High-throughput

0.737

High

412066

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.737

High

683181

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.737

High

782764

1433G
14-3-3 protein gamma

2

20

High-throughput

0.737

High

782766

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.737

High

782768

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.737

High

782779

ZO1
Tight junction protein ZO-1

2

19

High-throughput

0.737

High

782833

ZO2
Tight junction protein ZO-2

2

14

High-throughput

0.737

High

782755

PAXI
Paxillin

5

20

Small-scale

0.702

High

274188

STK16
Serine/threonine-protein kinase 16

1

10

High-throughput

0.691

High

586605

CSK22
Casein kinase II subunit alpha'

1

7

High-throughput

0.691

High

782826

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

15

High-throughput

0.691

High

782836

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

20

High-throughput

0.691

High

601830

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.665

High

782776

CAV1
Caveolin-1

3

8

Small-scale

0.661

High

414802

CDK1
Cyclin-dependent kinase 1

1

14

Small-scale

0.647

High

596369

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.647

High

616905

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.647

High

617084

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

20

High-throughput

0.647

High

617158

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

20

High-throughput

0.647

High

782752

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.647

High

782783

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.647

High

782790

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

20

High-throughput

0.647

High

782792

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

20

High-throughput

0.647

High

782824

SRCN1
SRC kinase signaling inhibitor 1

2

8

Small-scale

0.634

High

411329

INSR
Insulin receptor

1

20

Small-scale

0.621

High

681710

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.618

High

782762

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.618

High

782778

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

782781

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

782800

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

782825

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

610276

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.611

High

782780

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

19

Small-scale

0.586

High

782757

ARRB1
Beta-arrestin-1

2

7

Small-scale

0.584

High

401572

JUN
Transcription factor Jun

2

4

Small-scale

0.576

High

383665

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.575

High

782782

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

388278

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

393083

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

2

High-throughput

0.571

High

397303

ADT2
ADP/ATP translocase 2

2

2

High-throughput

0.571

High

431619

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.571

High

437960

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.571

High

501787

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

503596

HSP7C
Heat shock cognate 71 kDa protein

2

13

High-throughput

0.571

High

506440

RALB
Ras-related protein Ral-B

2

17

High-throughput

0.571

High

564025

HSP76
Heat shock 70 kDa protein 6

2

13

High-throughput

0.571

High

653181

PYR1
Multifunctional protein CAD

2

4

High-throughput

0.571

High

681357

DNJA1
DnaJ homolog subfamily A member 1

2

5

High-throughput

0.571

High

684476

STIP1
Stress-induced-phosphoprotein 1

2

3

High-throughput

0.571

High

714124

HSP74
Heat shock 70 kDa protein 4

2

19

High-throughput

0.571

High

716614

CTNA1
Catenin alpha-1

2

4

High-throughput

0.571

High

751516

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

782770

TYB10
Thymosin beta-10

2

1

High-throughput

0.571

High

782771

TBA1B
Tubulin alpha-1B chain

2

11

High-throughput

0.571

High

782773

S25A3
Solute carrier family 25 member 3

2

4

High-throughput

0.571

High

782791

CDC37
Hsp90 co-chaperone Cdc37

2

11

High-throughput

0.571

High

782813

HS105
Heat shock protein 105 kDa

2

19

High-throughput

0.571

High

782817

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

9

High-throughput

0.571

High

782834

DPP2
Dipeptidyl peptidase 2

2

1

High-throughput

0.571

High

782807

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

1

12

Small-scale

0.562

High

596510

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

2

Small-scale

0.561

High

782763

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

10

Small-scale

0.561

High

782772

DAB2
Disabled homolog 2

1

20

Small-scale

0.561

High

782787

DAG1
Dystroglycan 1

1

10

Small-scale

0.561

High

660420

GRN
Progranulin

2

0

High-throughput

0.547

High

782756

FAS
Fatty acid synthase

2

0

High-throughput

0.547

High

782760

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.547

High

782753

SPB4
Serpin B4

1

2

High-throughput

0.536

High

782815

RAD50
DNA repair protein RAD50

1

13

High-throughput

0.536

High

782785

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

Small-scale

0.534

High

782818

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.515

High

212369

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

782803

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

782775

ID3
DNA-binding protein inhibitor ID-3

1

1

Small-scale

0.508

High

782788

FHL2
Four and a half LIM domains protein 2

1

20

Small-scale

0.508

High

180655

RGS16
Regulator of G-protein signaling 16

1

3

Small-scale

0.501

High

200163

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

20

Small-scale

0.501

High

235051

DOK2
Docking protein 2

1

20

Small-scale

0.501

High

253696

SDC3
Syndecan-3

1

6

Small-scale

0.501

High

430689

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.501

High

557440

PECA1
Platelet endothelial cell adhesion molecule

1

17

Small-scale

0.501

High

566953

CXA1
Gap junction alpha-1 protein

1

11

Small-scale

0.501

High

782812

SCRB1
Scavenger receptor class B member 1

1

6

Small-scale

0.501

High

782769

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

130782

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

277975

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.479

High

302489

CE152
Centrosomal protein of 152 kDa

1

6

High-throughput

0.479

High

418008

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

552131

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

650563

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

685825

ARRB2
Beta-arrestin-2

1

7

Small-scale

0.479

High

742103

SYUA
Alpha-synuclein

1

6

High-throughput

0.479

High

782758

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

782759

R144A
E3 ubiquitin-protein ligase RNF144A

1

2

Small-scale

0.479

High

782796

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

782801

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

782804

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

Small-scale

0.479

High

782806

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

782808

RIN3
Ras and Rab interactor 3

1

18

High-throughput

0.479

High

782810

PARD3
Partitioning defective 3 homolog

1

14

Small-scale

0.479

High

782814

DNSL2
Deoxyribonuclease-1-like 2

1

2

High-throughput

0.479

High

782816

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

782822

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

782835

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

782838

TRAF6
TNF receptor-associated factor 6

1

15

Small-scale

0.479

High

782840

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.479

High

782832

ZN212
Zinc finger protein 212

1

5

Small-scale

0.464

High

782761

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

782765

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

782784

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

782819

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

782821

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

264186

CDC45
Cell division control protein 45 homolog

1

2

Small-scale

0.457

High

782798

LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

1

8

Small-scale

0.457

High

782799

SCIMP
SLP adapter and CSK-interacting membrane protein

1

1

Small-scale

0.457

High

382337

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

782754

HSP77
Putative heat shock 70 kDa protein 7

1

14

High-throughput

0.445

High

782793

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.445

High

782823

CD244
Natural killer cell receptor 2B4

1

15

Small-scale

0.445

High

719867

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

782789

PDIA5
Protein disulfide-isomerase A5

1

6

High-throughput

0.437

High

782820

CIC
Protein capicua homolog

1

13

High-throughput

0.437

High

782831

RRBP1
Ribosome-binding protein 1

1

10

High-throughput

0.437

High

782839

NCOR2
Nuclear receptor corepressor 2

1

6

High-throughput

0.437

High

782805

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

782830

T161A
Transmembrane protein 161A

2

0

High-throughput

0.298

High

782786

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

782774

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.249

Low

782809

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

782827

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024