Protein: DFFB
DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40)

Gene: DFFB
Organism: Homo sapiens
Interactions: 34
UniProt ID: O76075

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0004520 - DNA endonuclease activity
GO:0004536 - DNA nuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130816

DFFA
DNA fragmentation factor subunit alpha

11

4

Small-scale

0.976

High

303055

CIDEB
Lipid transferase CIDEB

1

4

Small-scale

0.647

High

303038

MGN
Protein mago nashi homolog

3

0

High-throughput

0.638

High

303028

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.602

High

303034

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

0

High-throughput

0.602

High

303040

PTN13
Tyrosine-protein phosphatase non-receptor type 13

2

0

High-throughput

0.602

High

303044

PKN2
Serine/threonine-protein kinase N2

2

0

High-throughput

0.602

High

303046

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.536

High

303027

VIME
Vimentin

1

1

High-throughput

0.515

High

303029

TOP2A
DNA topoisomerase 2-alpha

1

1

Small-scale

0.501

High

303030

NFH
Neurofilament heavy polypeptide

1

1

High-throughput

0.489

High

303025

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

303045

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

193477

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

High-throughput

0.479

High

240328

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

303041

CUL1
Cullin-1

1

2

High-throughput

0.479

High

303042

CUL2
Cullin-2

1

2

High-throughput

0.479

High

303043

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.479

High

303051

CUL5
Cullin-5

1

2

High-throughput

0.479

High

303031

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

303035

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

303047

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.458

High

303050

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

303032

H15
Histone H1.5

1

2

Small-scale

0.445

High

303033

H13
Histone H1.3

1

2

Small-scale

0.445

High

303037

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.445

High

303039

H11
Histone H1.1

1

2

Small-scale

0.445

High

303026

H10
Histone H1.0

1

0

Small-scale

0.426

High

303036

BMI1
Polycomb complex protein BMI-1

1

0

Small-scale

0.426

High

303052

F111A
Serine protease FAM111A

1

0

High-throughput

0.426

High

303054

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.426

High

303048

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.407

High

303049

LRC15
Leucine-rich repeat-containing protein 15

2

0

High-throughput

0.328

High

303053

TR61B
tRNA

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025