Protein: DHX58
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)

Gene: DHX58
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q96C10

Gene Ontology (top 5):
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003677 - DNA binding
GO:0003724 - RNA helicase activity
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

345101

RIGI
Antiviral innate immune response receptor RIG-I

3

18

Small-scale

0.827

High

1385367

IFIH1
Interferon-induced helicase C domain-containing protein 1

3

18

Small-scale

0.827

High

624113

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

19

High-throughput

0.757

High

1271487

DHX30
ATP-dependent RNA helicase DHX30

1

20

High-throughput

0.757

High

1385369

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

20

High-throughput

0.757

High

1385373

DICER
Endoribonuclease Dicer

1

15

High-throughput

0.757

High

346171

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.691

High

183051

NKRF
NF-kappa-B-repressing factor

1

5

High-throughput

0.677

High

1121297

TRI14
Tripartite motif-containing protein 14

1

20

Small-scale

0.647

High

1125181

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.618

High

1278062

MAVS
Mitochondrial antiviral-signaling protein

1

12

Small-scale

0.618

High

422832

A4
Amyloid-beta precursor protein

2

8

High-throughput

0.602

High

941231

IF6
Eukaryotic translation initiation factor 6

1

2

High-throughput

0.586

High

1385372

AGO2
Protein argonaute-2

1

20

High-throughput

0.586

High

1307222

RN135
E3 ubiquitin-protein ligase RNF135

1

20

Small-scale

0.575

High

1385368

XRN2
5'-3' exoribonuclease 2

1

4

High-throughput

0.536

High

1161595

IF16
Gamma-interferon-inducible protein 16

1

15

High-throughput

0.515

High

989073

AP2B1
AP-2 complex subunit beta

1

7

High-throughput

0.494

High

1385370

CARF
CDKN2A-interacting protein

1

5

High-throughput

0.489

High

136716

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

1037808

IRF8
Interferon regulatory factor 8

1

11

Small-scale

0.479

High

1090844

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1094948

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1281582

SLN11
Schlafen family member 11

1

4

High-throughput

0.479

High

1385371

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

12

Small-scale

0.479

High

1385374

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

372789

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.445

High


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Last updated: 11Aug2025