Protein: RN135
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)

Gene: RN135, RNF135
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q8IUD6

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

345090

RIGI
Antiviral innate immune response receptor RIG-I

7

19

Small-scale

0.973

High

1307220

RN135
E3 ubiquitin-protein ligase RNF135

5

18

Small-scale

0.924

High

1219926

BSPRY
B box and SPRY domain-containing protein

2

16

High-throughput

0.811

High

1307227

CTNL1
Alpha-catulin

5

2

High-throughput

0.725

High

957784

UBE2N
Ubiquitin-conjugating enzyme E2 N

4

20

Small-scale

0.698

High

1307224

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

18

Small-scale

0.647

High

269270

HSF2B
Heat shock factor 2-binding protein

3

0

High-throughput

0.636

High

821142

TXLNA
Alpha-taxilin

2

16

High-throughput

0.628

High

1140103

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

1

High-throughput

0.628

High

1307225

E41L5
Band 4.1-like protein 5

2

7

High-throughput

0.628

High

1307228

TES
Testin

2

5

High-throughput

0.628

High

1125150

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

19

Small-scale

0.618

High

1063397

GOGA2
Golgin subfamily A member 2

3

11

High-throughput

0.616

High

1307223

AP4AT
AP-4 complex accessory subunit Tepsin

2

3

High-throughput

0.606

High

1104916

XRCC4
DNA repair protein XRCC4

2

0

High-throughput

0.602

High

1118816

TF2H2
General transcription factor IIH subunit 2

2

0

High-throughput

0.602

High

1307222

DHX58
ATP-dependent RNA helicase DHX58

1

20

Small-scale

0.575

High

1278025

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.561

High

941484

CTBP2
C-terminal-binding protein 2

2

2

High-throughput

0.553

High

475770

K2C7
Keratin, type II cytoskeletal 7

1

5

High-throughput

0.536

High

1307226

KLH42
Kelch-like protein 42

1

5

High-throughput

0.536

High

1307230

TACC3
Transforming acidic coiled-coil-containing protein 3

1

9

High-throughput

0.536

High

982236

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.501

High

1156640

ENOX2
Ecto-NOX disulfide-thiol exchanger 2

1

1

High-throughput

0.481

High

1275548

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

5

Small-scale

0.479

High

1307229

PLAT4
Phospholipase A and acyltransferase 4

1

1

Small-scale

0.479

High

246734

KDM1A
Lysine-specific histone demethylase 1A

1

5

Small-scale

0.437

High

1307221

NIN
Ninein

1

12

High-throughput

0.437

High


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Last updated: 11Aug2025