HitPredict

Interactor 1: CLH (P22137)
Clathrin heavy chain
Gene: CHC1

Interactor 2: ENT2 (Q05785)
Epsin-2
Gene: ENT2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	14704157, 32400111, 37968396
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0030125 - clathrin vesicle coat
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1653 Sc			1 613
+	Hs
		960794 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN4_HUMAN (3-575): 9.26e-84: 276: 16.80
+	Rn
		291386 CLH1_RAT (4-1648): 0: 2901: 49.76		EPN1_RAT (2-542): 1.59e-85: 279: 18.92
+	Hs
		961040 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN1_HUMAN (2-542): 1.93e-82: 271: 18.89
+	Hs
		960815 CLH1_HUMAN (4-1648): 0: 2909: 49.76		ITSN1_HUMAN (123-593): 6.84e-49: 186: 15.39
+	Dm
		669592 CLH_DROME (4-1650): 0: 2804: 48.58		Q7KU90_DROME (5-606): 5.78e-72: 249: 20.57
+	Hs
		863938 CLH2_HUMAN (4-1635): 0: 2773: 48.90		EPN4_HUMAN (3-575): 9.26e-84: 276: 16.80
+	Hs
		307526 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN2_HUMAN (182-557): 9.06e-16: 82.8: 10.03
+	At
		1012797 CLAH1_ARATH (2-1642): 0: 2628: 43.39		EPN1_ARATH (3-437): 3.63e-74: 249: 16.74
+	At
		1012719 CLAH2_ARATH (2-1635): 0: 2640: 43.64		EPN2_ARATH (3-595): 1.11e-65: 232: 17.61
+	Sc
		604493 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT1_YEAST (1-514): 2.63e-90: 288: 50.97
+	Sc
		604440 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT3_YEAST (2-380): 2.25e-81: 263: 18.06
+	Sc
		604463 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT5_YEAST (3-343): 4.75e-48: 175: 17.02