Protein: RHBT3
Rho-related BTB domain-containing protein 3 (EC 3.6.1.-)

Gene: RHBT3, RHOBTB3
Organism: Homo sapiens
Interactions: 104
UniProt ID: O94955

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008584 - male gonad development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322725

CUL3
Cullin-3

9

20

Small-scale

0.972

High

154784

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

9

High-throughput

0.861

High

322767

ZRAN1
Ubiquitin thioesterase ZRANB1

3

6

High-throughput

0.843

High

322754

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

2

6

High-throughput

0.811

High

322686

RHBT3
Rho-related BTB domain-containing protein 3

2

14

Small-scale

0.800

High

258691

DNJA2
DnaJ homolog subfamily A member 2

2

6

High-throughput

0.776

High

322709

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.740

High

322759

RHBT2
Rho-related BTB domain-containing protein 2

1

20

Small-scale

0.713

High

154924

BHE40
Class E basic helix-loop-helix protein 40

4

4

High-throughput

0.698

High

322708

GPV
Platelet glycoprotein V

1

5

High-throughput

0.691

High

322760

RTN4R
Reticulon-4 receptor

1

16

High-throughput

0.691

High

322712

RAB9A
Ras-related protein Rab-9A

1

20

Small-scale

0.680

High

322719

CD83
CD83 antigen

2

0

High-throughput

0.679

High

322745

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.679

High

322700

TNR6
Tumor necrosis factor receptor superfamily member 6

3

19

High-throughput

0.667

High

322713

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

2

High-throughput

0.667

High

322769

PCYOX
Prenylcysteine oxidase 1

3

0

High-throughput

0.634

High

322702

IL1R2
Interleukin-1 receptor type 2

2

16

High-throughput

0.628

High

322717

ARF5
ADP-ribosylation factor 5

2

20

High-throughput

0.628

High

322746

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

17

High-throughput

0.618

High

322690

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

322692

RHOC
Rho-related GTP-binding protein RhoC

1

18

High-throughput

0.618

High

322711

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

3

3

High-throughput

0.609

High

322720

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

17

High-throughput

0.609

High

322732

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.601

High

322750

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.601

High

322763

RAB9B
Ras-related protein Rab-9B

1

20

Small-scale

0.590

High

322730

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.578

High

322735

VASN
Vasorin

1

12

High-throughput

0.575

High

322698

IL4RA
Interleukin-4 receptor subunit alpha

2

16

High-throughput

0.574

High

322699

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.561

High

322715

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.561

High

322731

EFHC2
EF-hand domain-containing family member C2

2

6

High-throughput

0.553

High

322753

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

5

High-throughput

0.553

High

322756

TBX15
T-box transcription factor TBX15

2

1

High-throughput

0.553

High

322771

PLAL2
Zinc finger protein PLAGL2

2

2

High-throughput

0.553

High

50465

HACL2
2-hydroxyacyl-CoA lyase 2

2

1

High-throughput

0.549

High

322687

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

4

High-throughput

0.536

High

322694

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

15

High-throughput

0.536

High

322697

CAH6
Carbonic anhydrase 6

1

2

High-throughput

0.536

High

322706

BASI
Basigin

1

17

High-throughput

0.536

High

322744

ARRD4
Arrestin domain-containing protein 4

1

2

High-throughput

0.536

High

322751

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

6

High-throughput

0.536

High

322752

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

322773

KLK5
Kallikrein-5

1

6

High-throughput

0.536

High

253035

PLIN3
Perilipin-3

1

0

Small-scale

0.513

High

322689

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

322693

FURIN
Furin

1

0

High-throughput

0.513

High

322741

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

322758

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

322764

I17RB
Interleukin-17 receptor B

1

0

High-throughput

0.513

High

322775

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

169366

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

13

Small-scale

0.501

High

182443

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.489

High

231290

EFNA2
Ephrin-A2

1

12

High-throughput

0.489

High

270197

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

6

High-throughput

0.489

High

322701

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

11

High-throughput

0.489

High

322703

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

18

High-throughput

0.489

High

322718

IDD
Integral membrane protein DGCR2/IDD

1

20

High-throughput

0.489

High

322722

TNR9
Tumor necrosis factor receptor superfamily member 9

1

19

High-throughput

0.489

High

322724

KLRD1
Natural killer cells antigen CD94

1

15

High-throughput

0.489

High

322733

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

15

High-throughput

0.489

High

322743

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

1

High-throughput

0.489

High

322747

PO210
Nuclear pore membrane glycoprotein 210

1

2

High-throughput

0.489

High

322757

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

4

High-throughput

0.489

High

322762

KLK15
Kallikrein-15

1

8

High-throughput

0.489

High

322765

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

4

High-throughput

0.489

High

322770

CLC2D
C-type lectin domain family 2 member D

1

15

High-throughput

0.489

High

322772

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.489

High

322774

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.489

High

322707

SYUA
Alpha-synuclein

1

6

High-throughput

0.481

High

292967

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

322691

HS90A
Heat shock protein HSP 90-alpha

1

11

Small-scale

0.479

High

322705

5HT7R
5-hydroxytryptamine receptor 7

1

2

Small-scale

0.479

High

322729

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

322738

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.479

High

322739

CEP97
Centrosomal protein of 97 kDa

1

16

Small-scale

0.479

High

322761

EGLN1
Egl nine homolog 1

1

6

Small-scale

0.479

High

322768

LIMD1
LIM domain-containing protein 1

1

13

Small-scale

0.479

High

322749

JPH3
Junctophilin-3

1

13

High-throughput

0.470

High

322695

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

322728

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

322736

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

174471

TRI66
Tripartite motif-containing protein 66

1

9

High-throughput

0.437

High

255947

S19A2
Thiamine transporter 1

1

5

High-throughput

0.407

High

322696

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

322727

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.407

High

322737

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

322740

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

322714

DSCR6
Protein ripply3

1

0

High-throughput

0.282

High

260819

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

322688

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

322704

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

322710

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

322716

X3CL1
Fractalkine

1

0

High-throughput

0.279

Low

322721

ZP2
Zona pellucida sperm-binding protein 2

1

0

High-throughput

0.279

Low

322723

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

322726

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

322742

TM130
Transmembrane protein 130

1

0

High-throughput

0.279

Low

322748

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

0

High-throughput

0.279

Low

322755

OPALI
Opalin

1

0

High-throughput

0.279

Low

322766

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

322734

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025