Protein: PRKY
Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1)

Gene: PRKY
Organism: Homo sapiens
Interactions: 134
UniProt ID: O43930

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004691 - cAMP-dependent protein kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005952 - cAMP-dependent protein kinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

231581

MK14
Mitogen-activated protein kinase 14

2

13

High-throughput

0.712

High

231582

MAPK3
MAP kinase-activated protein kinase 3

2

12

High-throughput

0.712

High

231546

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

161685

APAF
Apoptotic protease-activating factor 1

1

3

High-throughput

0.575

High

167774

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

High-throughput

0.575

High

171636

GAK
Cyclin-G-associated kinase

1

17

High-throughput

0.575

High

177745

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.575

High

224059

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

20

High-throughput

0.575

High

231541

KS6A4
Ribosomal protein S6 kinase alpha-4

1

16

High-throughput

0.575

High

231543

DNJB5
DnaJ homolog subfamily B member 5

1

11

High-throughput

0.575

High

231544

OXSR1
Serine/threonine-protein kinase OSR1

1

18

High-throughput

0.575

High

231547

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

18

High-throughput

0.575

High

231548

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

20

High-throughput

0.575

High

231549

MK08
Mitogen-activated protein kinase 8

1

12

High-throughput

0.575

High

231550

MAPK2
MAP kinase-activated protein kinase 2

1

12

High-throughput

0.575

High

231560

RN5A
2-5A-dependent ribonuclease

1

8

High-throughput

0.575

High

231562

KIF1A
Kinesin-like protein KIF1A

1

3

High-throughput

0.575

High

231568

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

17

High-throughput

0.575

High

231569

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

13

High-throughput

0.575

High

231571

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

7

High-throughput

0.575

High

231574

MELK
Maternal embryonic leucine zipper kinase

1

17

High-throughput

0.575

High

231599

DGKH
Diacylglycerol kinase eta

1

7

High-throughput

0.575

High

231611

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

8

High-throughput

0.575

High

231615

GWL
Serine/threonine-protein kinase greatwall

1

17

High-throughput

0.575

High

231617

KI16B
Kinesin-like protein KIF16B

1

2

High-throughput

0.575

High

231619

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

19

High-throughput

0.575

High

231621

DNJC2
DnaJ homolog subfamily C member 2

1

11

High-throughput

0.575

High

231625

DUS9
Dual specificity protein phosphatase 9

1

4

High-throughput

0.575

High

231639

ARP8
Actin-related protein 8

1

7

High-throughput

0.575

High

231642

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.575

High

231649

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

19

High-throughput

0.575

High

231653

TBD2B
TBC1 domain family member 2B

1

9

High-throughput

0.575

High

231539

NBN
Nibrin

1

0

High-throughput

0.546

High

231558

FOXK2
Forkhead box protein K2

1

11

High-throughput

0.514

High

231589

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

3

High-throughput

0.514

High

231607

ZN507
Zinc finger protein 507

1

1

High-throughput

0.514

High

231614

CELF1
CUGBP Elav-like family member 1

1

7

High-throughput

0.514

High

231648

RBL2A
Rab-like protein 2A

1

11

High-throughput

0.514

High

231654

SCML2
Sex comb on midleg-like protein 2

1

1

High-throughput

0.514

High

231590

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

0

High-throughput

0.481

High

231598

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.481

High

231657

SALL2
Sal-like protein 2

1

0

High-throughput

0.481

High

159429

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

9

High-throughput

0.445

High

187424

FANCA
Fanconi anemia group A protein

1

2

High-throughput

0.445

High

228887

CF410
Cilia- and flagella-associated protein 410

1

4

High-throughput

0.445

High

231542

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.445

High

231545

GCR
Glucocorticoid receptor

1

18

High-throughput

0.445

High

231553

KIF11
Kinesin-like protein KIF11

1

3

High-throughput

0.445

High

231554

CLH2
Clathrin heavy chain 2

1

3

High-throughput

0.445

High

231555

CORO7
Coronin-7

1

5

High-throughput

0.445

High

231556

TBA4A
Tubulin alpha-4A chain

1

5

High-throughput

0.445

High

231559

GCYB1
Guanylate cyclase soluble subunit beta-1

1

1

High-throughput

0.445

High

231561

HSP7E
Heat shock 70 kDa protein 14

1

6

High-throughput

0.445

High

231566

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

8

High-throughput

0.445

High

231567

SKP2
S-phase kinase-associated protein 2

1

2

High-throughput

0.445

High

231570

PEX6
Peroxisomal ATPase PEX6

1

6

High-throughput

0.445

High

231573

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.445

High

231575

KIF22
Kinesin-like protein KIF22

1

4

High-throughput

0.445

High

231579

ELF2
ETS-related transcription factor Elf-2

1

2

High-throughput

0.445

High

231583

ERC6L
DNA excision repair protein ERCC-6-like

1

4

High-throughput

0.445

High

231587

GRAP1
GRIP1-associated protein 1

1

13

High-throughput

0.445

High

231588

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

20

High-throughput

0.445

High

231593

FIGL1
Fidgetin-like protein 1

1

10

High-throughput

0.445

High

231595

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.445

High

231601

FOXP4
Forkhead box protein P4

1

3

High-throughput

0.445

High

231603

SIX5
Homeobox protein SIX5

1

2

High-throughput

0.445

High

231605

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

1

High-throughput

0.445

High

231608

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

1

High-throughput

0.445

High

231609

CTF18
Chromosome transmission fidelity protein 18 homolog

1

7

High-throughput

0.445

High

231612

AKAP1
A-kinase anchor protein 1, mitochondrial

1

5

High-throughput

0.445

High

231613

RAD50
DNA repair protein RAD50

1

14

High-throughput

0.445

High

231622

T22D3
TSC22 domain family protein 3

1

4

High-throughput

0.445

High

231641

HELLS
Lymphoid-specific helicase

1

5

High-throughput

0.445

High

231646

CXXC1
CXXC-type zinc finger protein 1

1

2

High-throughput

0.445

High

231650

NB5R1
NADH-cytochrome b5 reductase 1

1

3

High-throughput

0.445

High

231652

TTF2
Transcription termination factor 2

1

6

High-throughput

0.445

High

231655

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.445

High

231656

FBX7
F-box only protein 7

1

4

High-throughput

0.445

High

231658

ARIP4
Helicase ARIP4

1

7

High-throughput

0.445

High

231660

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.445

High

135756

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.426

High

230855

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.426

High

231538

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.426

High

231551

DNLI3
DNA ligase 3

1

0

High-throughput

0.426

High

231552

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.426

High

231565

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.426

High

231576

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.426

High

231596

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.426

High

231597

CENPV
Centromere protein V

1

0

High-throughput

0.426

High

231610

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.426

High

231616

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

231624

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.426

High

231626

CND3
Condensin complex subunit 3

1

0

High-throughput

0.426

High

231632

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.426

High

231645

UBIP1
Upstream-binding protein 1

1

0

High-throughput

0.426

High

231557

VIGLN
Vigilin

1

6

High-throughput

0.407

High

231563

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.407

High

231564

FOXF2
Forkhead box protein F2

1

8

High-throughput

0.407

High

231572

MPP2
MAGUK p55 subfamily member 2

1

2

High-throughput

0.407

High

231577

MARE2
Microtubule-associated protein RP/EB family member 2

1

4

High-throughput

0.407

High

231578

NCOA2
Nuclear receptor coactivator 2

1

3

High-throughput

0.407

High

231580

TBCE
Tubulin-specific chaperone E

1

3

High-throughput

0.407

High

231584

QRIC1
Transcriptional regulator QRICH1

1

1

High-throughput

0.407

High

231591

INT3
Integrator complex subunit 3

1

1

High-throughput

0.407

High

231592

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

2

High-throughput

0.407

High

231594

STXB4
Syntaxin-binding protein 4

1

13

High-throughput

0.407

High

231600

I2BP1
Interferon regulatory factor 2-binding protein 1

1

2

High-throughput

0.407

High

231602

SMYD4
Protein-lysine N-methyltransferase SMYD4

1

4

High-throughput

0.407

High

231604

BANP
Protein BANP

1

1

High-throughput

0.407

High

231620

IF140
Intraflagellar transport protein 140 homolog

1

2

High-throughput

0.407

High

231623

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

1

High-throughput

0.407

High

231633

PCGF6
Polycomb group RING finger protein 6

1

8

High-throughput

0.407

High

231634

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.407

High

231637

IFT22
Intraflagellar transport protein 22 homolog

1

5

High-throughput

0.407

High

231638

TBA4B
Tubulin-like protein alpha-4B

1

4

High-throughput

0.407

High

231640

D39U1
Epimerase family protein SDR39U1

1

1

High-throughput

0.407

High

231647

POGK
Pogo transposable element with KRAB domain

1

1

High-throughput

0.407

High

231651

SIX4
Homeobox protein SIX4

1

2

High-throughput

0.407

High

66092

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.232

Low

231540

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.232

Low

231585

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.232

Low

231586

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.232

Low

231606

NAV1
Neuron navigator 1

1

0

High-throughput

0.232

Low

231618

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.232

Low

231627

APOL2
Apolipoprotein L2

1

0

High-throughput

0.232

Low

231628

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.232

Low

231629

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.232

Low

231630

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.232

Low

231631

PRR14
Proline-rich protein 14

1

0

High-throughput

0.232

Low

231635

MFF
Mitochondrial fission factor

1

0

High-throughput

0.232

Low

231636

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.232

Low

231643

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.232

Low

231644

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.232

Low

231659

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025