Protein: MEST
Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein)

Gene: MEST
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q5EB52

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0007498 - mesoderm development
GO:0010883 - regulation of lipid storage
GO:0016787 - hydrolase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1204164

RN19B
E3 ubiquitin-protein ligase RNF19B

2

2

High-throughput

0.606

High

1204178

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.580

High

563869

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.552

High

396260

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

1204179

FBX2
F-box only protein 2

1

0

High-throughput

0.513

High

1204169

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.508

High

422261

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

1064693

CLM6
CMRF35-like molecule 6

1

1

High-throughput

0.494

High

1204163

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.486

High

169582

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

955254

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

962127

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

1160647

DREB
Drebrin

1

1

High-throughput

0.464

High

1204168

ING5
Inhibitor of growth protein 5

1

2

High-throughput

0.464

High

856724

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.460

High

646857

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

218266

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

318799

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

904809

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

910082

RND2
Rho-related GTP-binding protein RhoN

1

1

High-throughput

0.437

High

1151721

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.437

High

1204165

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

350545

CF047
Uncharacterized protein C6orf47

2

0

High-throughput

0.316

High

1050848

DCE2
Glutamate decarboxylase 2

2

0

High-throughput

0.316

High

1204173

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

1204174

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

0

High-throughput

0.316

High

249380

MPZL2
Myelin protein zero-like protein 2

1

0

High-throughput

0.282

High

701836

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.269

Low

1204175

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.269

Low

329182

RHIT
Transcriptional repressor RHIT

1

0

High-throughput

0.265

Low

626963

FST
Follistatin

1

0

High-throughput

0.265

Low

1204162

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.265

Low

1204166

ZN579
Zinc finger protein 579

1

0

High-throughput

0.265

Low

1204167

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.265

Low

1204171

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

High-throughput

0.265

Low

1204172

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.265

Low

1204181

FBX7
F-box only protein 7

1

0

High-throughput

0.261

Low

791437

SYUA
Alpha-synuclein

1

0

High-throughput

0.249

Low

872401

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

1204176

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1204177

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1204180

SNX7
Sorting nexin-7

1

0

High-throughput

0.238

Low

529927

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

1204170

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025