Protein: SMYD3
Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)

Gene: SMYD3
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q9H7B4

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000993 - RNA polymerase II complex binding
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461940

HS90A
Heat shock protein HSP 90-alpha

4

6

Small-scale

0.694

High

980328

H4
Histone H4

1

3

High-throughput

0.691

High

1332942

SMYD1
Histone-lysine N-methyltransferase SMYD1

1

1

High-throughput

0.691

High

468811

HS90B
Heat shock protein HSP 90-beta

4

6

High-throughput

0.691

High

1239481

H3C
Histone H3.3C

1

7

High-throughput

0.656

High

1162044

H31T
Histone H3.1t

1

7

Small-scale

0.647

High

1435630

RCAN3
Calcipressin-3

3

0

High-throughput

0.638

High

667455

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.618

High

1255560

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.618

High

1435633

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

0

Small-scale

0.598

High

1316161

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

0

Small-scale

0.586

High

1273164

KDM3B
Lysine-specific demethylase 3B

2

0

High-throughput

0.585

High

1093720

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

1157496

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.580

High

1363736

SHC3
SHC-transforming protein 3

2

0

High-throughput

0.580

High

1430184

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

0

High-throughput

0.580

High

396955

ESR1
Estrogen receptor

1

1

Small-scale

0.561

High

414635

P53
Cellular tumor antigen p53

1

2

Small-scale

0.561

High

1202008

H90B4
Putative heat shock protein HSP 90-beta 4

2

6

High-throughput

0.552

High

564379

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

1110299

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.541

High

1144164

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1158549

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.536

High

1259683

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

156503

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.518

High

670086

NFYB
Nuclear transcription factor Y subunit beta

1

0

High-throughput

0.518

High

1395290

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

1156057

ZIC1
Zinc finger protein ZIC 1

1

3

High-throughput

0.515

High

192023

GLYG2
Glycogenin-2

1

0

High-throughput

0.513

High

428517

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.513

High

584807

NDKA
Nucleoside diphosphate kinase A

1

0

High-throughput

0.513

High

648311

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.513

High

906179

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.513

High

961404

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.513

High

975947

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

1094120

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.513

High

1383857

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1415018

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.513

High

1202074

HS905
Putative heat shock protein HSP 90-alpha A5

2

7

High-throughput

0.504

High

996856

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.489

High

1432609

MOD5
tRNA dimethylallyltransferase

1

0

High-throughput

0.486

High

1331736

ZN557
Zinc finger protein 557

1

1

High-throughput

0.481

High

194349

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.480

High

423182

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

242939

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

1161400

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.479

High

1258812

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

Small-scale

0.458

High

1276794

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1394956

MAGD4
Melanoma-associated antigen D4

1

0

High-throughput

0.458

High

1396811

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1432354

PININ
Pinin

1

0

High-throughput

0.458

High

1202030

H90B3
Putative heat shock protein HSP 90-beta-3

1

6

High-throughput

0.445

High

1430721

OSBL5
Oxysterol-binding protein-related protein 5

1

1

High-throughput

0.445

High

823914

PBX2
Pre-B-cell leukemia transcription factor 2

1

0

Small-scale

0.438

High

1229229

ZNF57
Zinc finger protein 57

1

0

High-throughput

0.438

High

262308

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.407

High

517263

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

1435631

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

1276160

NUP54
Nucleoporin p54

2

0

High-throughput

0.316

High

1346643

VANG1
Vang-like protein 1

1

0

High-throughput

0.282

High

1435629

CP39A
24-hydroxycholesterol 7-alpha-hydroxylase

1

0

High-throughput

0.282

High

845480

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

High-throughput

0.279

Low

1158299

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.279

Low

1312764

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.279

Low

1382300

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

1435628

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.279

Low

1204175

MEST
Mesoderm-specific transcript homolog protein

1

0

High-throughput

0.269

Low

1435632

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.269

Low

1430115

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.268

Low

813220

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.249

Low

1358755

FACR1
Fatty acyl-CoA reductase 1

1

0

High-throughput

0.249

Low

640290

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.232

Low

1366237

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025