HitPredict
Protein: IL33
Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]

Gene: IL33
Organism: Homo sapiens
Interactions: 15
UniProt ID: O95760

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001819 - positive regulation of cytokine production
GO:0002112 - interleukin-33 receptor binding
GO:0002282 - microglial cell activation involved in immune response
GO:0002638 - negative regulation of immunoglobulin production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score		 Confidence

344439

 ILRL1
Interleukin-1 receptor-like 1

5

2

Small-scale

 0.931

High

344434

 CASP1
Caspase-1

2

2

Small-scale

 0.608

High

344438

 MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

 0.537

High

344445

 IL1AP
Interleukin-1 receptor accessory protein

1

2

Small-scale

 0.515

High

344441

 H2B2E
Histone H2B type 2-E

1

1

Small-scale

 0.501

High

344442

 H2A2A
Histone H2A type 2-A

1

1

Small-scale

 0.501

High

344433

 H2A1
Histone H2A type 1

1

1

Small-scale

 0.500

High

344444

 GALM
Galactose mutarotase

1

0

High-throughput

 0.493

High

344446

 UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

 0.479

High

172377

 XPO1
Exportin-1

1

0

High-throughput

 0.458

High

344443

 U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

0

Small-scale

 0.458

High

344435

 CASP3
Caspase-3

1

2

Small-scale

 0.445

High

344436

 CASP7
Caspase-7

1

2

Small-scale

 0.445

High

344437

 H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

Small-scale

 0.445

High

344440

 DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

 0.238

Low

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Last updated: 11Aug2025