Protein: G6PE
GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]

Gene: G6PE, H6PD
Organism: Homo sapiens
Interactions: 28
UniProt ID: O95479

Gene Ontology (top 5):
GO:0004345 - glucose-6-phosphate dehydrogenase activity
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006006 - glucose metabolic process
GO:0009051 - pentose-phosphate shunt, oxidative branch

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338245

FBX6
F-box only protein 6

6

1

High-throughput

0.729

High

338247

FBX2
F-box only protein 2

2

1

High-throughput

0.601

High

338226

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.536

High

338246

DNJB9
DnaJ homolog subfamily B member 9

1

1

High-throughput

0.536

High

338227

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

338241

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.513

High

338244

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

338225

CCL3
C-C motif chemokine 3

1

1

High-throughput

0.489

High

338230

CL3L1
C-C motif chemokine 3-like 1

1

1

High-throughput

0.489

High

338234

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.489

High

217664

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

240381

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

338224

CSH2
Chorionic somatomammotropin hormone 2

1

1

High-throughput

0.479

High

338223

CSH1
Chorionic somatomammotropin hormone 1

1

1

High-throughput

0.445

High

338228

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

338231

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

338238

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

338237

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

338236

TAZ
Tafazzin

3

0

High-throughput

0.347

High

338243

ANTR1
Anthrax toxin receptor 1

3

0

High-throughput

0.347

High

338229

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.279

Low

338232

PTGDS
Prostaglandin-H2 D-isomerase

1

0

High-throughput

0.279

Low

338233

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

338235

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

338239

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

338240

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.279

Low

338242

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

0

High-throughput

0.279

Low

338222

CRP

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025