Protein: DEF6
Defensin-6 (Defensin, alpha 6)

Gene: DEF6, DEFA6
Organism: Homo sapiens
Interactions: 23
UniProt ID: Q01524

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005796 - Golgi lumen
GO:0019731 - antibacterial humoral response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

634903

PZP
Pregnancy zone protein

2

1

High-throughput

0.628

High

1030830

VWA1
von Willebrand factor A domain-containing protein 1

2

4

High-throughput

0.628

High

1030831

POTEE
POTE ankyrin domain family member E

2

1

High-throughput

0.628

High

1030828

DEF6
Defensin-6

1

3

Small-scale

0.618

High

1030832

RBPS2
RNA-binding protein with multiple splicing 2

2

0

High-throughput

0.602

High

1030835

IP6K1
Inositol hexakisphosphate kinase 1

2

1

High-throughput

0.574

High

1030841

UBQL1
Ubiquilin-1

2

2

High-throughput

0.573

High

1030836

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

3

High-throughput

0.553

High

1030840

UBQL2
Ubiquilin-2

2

2

High-throughput

0.553

High

952754

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

1030829

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.536

High

1030839

CATF
Cathepsin F

1

2

High-throughput

0.536

High

1030838

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.513

High

421941

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

226754

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.439

High

230781

EXTL3
Exostosin-like 3

2

0

High-throughput

0.328

High

336095

ZFYV9
Zinc finger FYVE domain-containing protein 9

2

0

High-throughput

0.328

High

862047

YAP1
Transcriptional coactivator YAP1

2

0

High-throughput

0.328

High

1030833

FBX11
F-box only protein 11

2

0

High-throughput

0.328

High

1030834

FOG1
Zinc finger protein ZFPM1

2

0

High-throughput

0.328

High

1030837

MIPEP
Mitochondrial intermediate peptidase

2

0

High-throughput

0.328

High

879708

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025