Protein: EXTL3
Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3)

Gene: EXTL3
Organism: Homo sapiens
Interactions: 141
UniProt ID: O43909

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001888 - glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

230792

EXT1
Exostosin-1

1

12

High-throughput

0.691

High

230832

EXT2
Exostosin-2

1

12

High-throughput

0.691

High

230801

SCAR3
Scavenger receptor class A member 3

4

3

High-throughput

0.691

High

230831

LPAR1
Lysophosphatidic acid receptor 1

3

2

High-throughput

0.667

High

230804

S39A4
Zinc transporter ZIP4

3

12

High-throughput

0.650

High

230762

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

1

High-throughput

0.628

High

230767

5HT3A
5-hydroxytryptamine receptor 3A

2

6

High-throughput

0.628

High

230798

MPPE1
Metallophosphoesterase 1

2

2

High-throughput

0.628

High

230827

SPP2B
Signal peptide peptidase-like 2B

2

1

High-throughput

0.628

High

230843

IPPK
Inositol-pentakisphosphate 2-kinase

2

1

High-throughput

0.628

High

230725

ADCY9
Adenylate cyclase type 9

2

1

High-throughput

0.601

High

230764

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.601

High

230778

CXCR4
C-X-C chemokine receptor type 4

2

2

High-throughput

0.601

High

230796

SV2C
Synaptic vesicle glycoprotein 2C

2

4

High-throughput

0.601

High

230808

S39A5
Zinc transporter ZIP5

2

12

High-throughput

0.601

High

230811

SV2A
Synaptic vesicle glycoprotein 2A

2

4

High-throughput

0.601

High

230772

ATX1
Ataxin-1

2

0

High-throughput

0.580

High

230828

CA054
Uncharacterized protein C1orf54

2

3

High-throughput

0.549

High

160950

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.536

High

182425

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

213297

ADCY6
Adenylate cyclase type 6

1

1

High-throughput

0.536

High

230727

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.536

High

230734

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

230736

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

7

High-throughput

0.536

High

230737

ACHA
Acetylcholine receptor subunit alpha

1

5

High-throughput

0.536

High

230740

CD1A
T-cell surface glycoprotein CD1a

1

2

High-throughput

0.536

High

230744

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

230748

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.536

High

230749

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.536

High

230751

S1PR1
Sphingosine 1-phosphate receptor 1

1

3

High-throughput

0.536

High

230752

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

1

High-throughput

0.536

High

230757

5HT1B
5-hydroxytryptamine receptor 1B

1

2

High-throughput

0.536

High

230758

5HT2C
5-hydroxytryptamine receptor 2C

1

2

High-throughput

0.536

High

230765

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.536

High

230766

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

5

High-throughput

0.536

High

230784

KDSR
3-ketodihydrosphingosine reductase

1

1

High-throughput

0.536

High

230786

ACHD
Acetylcholine receptor subunit delta

1

5

High-throughput

0.536

High

230787

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

2

High-throughput

0.536

High

230814

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

1

High-throughput

0.536

High

230826

GOGA5
Golgin subfamily A member 5

1

1

High-throughput

0.536

High

230829

CLC2B
C-type lectin domain family 2 member B

1

5

High-throughput

0.536

High

230833

T106A
Transmembrane protein 106A

1

3

High-throughput

0.536

High

230846

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

230851

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.536

High

230836

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

141886

PODXL
Podocalyxin

1

0

High-throughput

0.513

High

230730

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

230731

KPCD3
Serine/threonine-protein kinase D3

1

0

High-throughput

0.513

High

230761

CD70
CD70 antigen

1

0

High-throughput

0.513

High

230770

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.513

High

230785

APLP2
Amyloid beta precursor like protein 2

1

0

High-throughput

0.513

High

230791

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.513

High

230797

MBRL
Membralin

1

0

High-throughput

0.513

High

230810

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.513

High

230820

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

230823

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

230838

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.513

High

230841

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

230728

SG2A1
Mammaglobin-B

1

4

High-throughput

0.489

High

230733

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

230738

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

1

High-throughput

0.489

High

230739

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

High-throughput

0.489

High

230742

SYPH
Synaptophysin

1

1

High-throughput

0.489

High

230743

PAEP
Glycodelin

1

1

High-throughput

0.489

High

230747

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.489

High

230756

DMB
HLA class II histocompatibility antigen, DM beta chain

1

6

High-throughput

0.489

High

230788

LAMB3
Laminin subunit beta-3

1

1

High-throughput

0.489

High

230793

CL12B
C-type lectin domain family 12 member B

1

5

High-throughput

0.489

High

230806

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.489

High

230816

S22A9
Organic anion transporter 7

1

3

High-throughput

0.489

High

230837

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

217570

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

230729

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

230741

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

230745

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

High-throughput

0.479

High

230753

GLRA2
Glycine receptor subunit alpha-2

1

3

High-throughput

0.479

High

230768

CRK
Adapter molecule crk

1

3

High-throughput

0.479

High

230779

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.479

High

230795

ZACN
Ligand-gated cation channel ZACN

1

7

High-throughput

0.479

High

230815

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

230848

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

230750

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.458

High

230755

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.458

High

230780

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

Small-scale

0.458

High

230782

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.458

High

170569

CLGN
Calmegin

1

3

High-throughput

0.445

High

178114

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.445

High

211096

CTR4
Cationic amino acid transporter 4

1

3

High-throughput

0.445

High

230746

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.445

High

230754

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.445

High

230759

5HT1E
5-hydroxytryptamine receptor 1E

1

2

High-throughput

0.445

High

230760

CTR1
High affinity cationic amino acid transporter 1

1

3

High-throughput

0.445

High

230763

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

230769

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

230771

CXCR3
C-X-C chemokine receptor type 3

1

2

High-throughput

0.445

High

230789

MF13A
Transmembrane protein 180

1

1

High-throughput

0.445

High

230790

S39AE
Metal cation symporter ZIP14

1

12

High-throughput

0.445

High

230802

MFSD5
Molybdate-anion transporter

1

3

High-throughput

0.445

High

230807

ZNT10
Calcium/manganese antiporter SLC30A10

1

9

High-throughput

0.445

High

230812

SV2B
Synaptic vesicle glycoprotein 2B

1

4

High-throughput

0.445

High

230813

OSTA
Organic solute transporter subunit alpha

1

2

High-throughput

0.445

High

230822

ZNT7
Zinc transporter 7

1

9

High-throughput

0.445

High

230824

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

9

High-throughput

0.445

High

230825

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

230830

S39A7
Zinc transporter SLC39A7

1

12

High-throughput

0.445

High

230839

S39A8
Metal cation symporter ZIP8

1

12

High-throughput

0.445

High

230840

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.445

High

230847

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

1

High-throughput

0.445

High

230809

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

230819

SYNE4
Nesprin-4

1

1

High-throughput

0.437

High

230726

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

230776

NAC3
Sodium/calcium exchanger 3

1

0

High-throughput

0.426

High

230783

P
P protein

1

0

High-throughput

0.426

High

230845

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

230799

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

230803

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.407

High

230817

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

230835

WBP1
WW domain-binding protein 1

3

0

High-throughput

0.347

High

230781

DEF6
Defensin-6

2

0

High-throughput

0.328

High

230794

TMM95
Sperm-egg fusion protein TMEM95

2

0

High-throughput

0.313

High

230844

PKHA5
Pleckstrin homology domain-containing family A member 5

1

0

High-throughput

0.282

High

66562

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

209710

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.279

Low

223573

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

223673

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

230732

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.279

Low

230735

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.279

Low

230773

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

230774

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

230775

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.279

Low

230800

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

230805

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

230818

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

230821

IN80E
INO80 complex subunit E

1

0

High-throughput

0.279

Low

230834

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.279

Low

230842

CST9L
Cystatin-9-like

1

0

High-throughput

0.279

Low

230849

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

230850

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.279

Low

230852

ANGP4
Angiopoietin-4

1

0

High-throughput

0.279

Low

230777

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

155534

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025