Protein: AP4AT
AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)

Gene: AP4AT, TEPSIN
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q96N21

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030662 - coated vesicle membrane
GO:0031090 - organelle membrane
GO:0032588 - trans-Golgi network membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1398688

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

Small-scale

0.706

High

125851

AP4M1
AP-4 complex subunit mu-1

3

2

Small-scale

0.673

High

1398749

AP4B1
AP-4 complex subunit beta-1

4

0

Small-scale

0.668

High

1398696

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

3

1

Small-scale

0.662

High

1398745

AP4S1
AP-4 complex subunit sigma-1

3

1

Small-scale

0.662

High

1398739

AP4E1
AP-4 complex subunit epsilon-1

3

0

Small-scale

0.645

High

250319

VINEX
Vinexin

2

1

High-throughput

0.606

High

300469

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.606

High

997952

CSK21
Casein kinase II subunit alpha

2

1

High-throughput

0.606

High

1102363

GRB10
Growth factor receptor-bound protein 10

2

1

High-throughput

0.606

High

1146107

K1H1
Keratin, type I cuticular Ha1

2

2

High-throughput

0.606

High

1156046

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.606

High

1229397

DUS29
Dual specificity phosphatase 29

2

1

High-throughput

0.606

High

1231186

TRI68
E3 ubiquitin-protein ligase TRIM68

2

2

High-throughput

0.606

High

1294326

TRI50
E3 ubiquitin-protein ligase TRIM50

2

2

High-throughput

0.606

High

1307223

RN135
E3 ubiquitin-protein ligase RNF135

2

3

High-throughput

0.606

High

1335242

KCTD6
BTB/POZ domain-containing protein KCTD6

2

1

High-throughput

0.606

High

1353523

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

2

High-throughput

0.606

High

1367974

KRT35
Keratin, type I cuticular Ha5

2

2

High-throughput

0.606

High

1398704

AP1M1
AP-1 complex subunit mu-1

2

2

High-throughput

0.606

High

1398705

TRI54
Tripartite motif-containing protein 54

2

3

High-throughput

0.606

High

1398714

TRI45
E3 ubiquitin-protein ligase TRIM45

2

2

High-throughput

0.606

High

1398715

PKHA2
Pleckstrin homology domain-containing family A member 2

2

1

High-throughput

0.606

High

1398722

TBC13
TBC1 domain family member 13

2

1

High-throughput

0.606

High

1398740

BTBD3
BTB/POZ domain-containing protein 3

2

1

High-throughput

0.606

High

1390280

TRI11
E3 ubiquitin-protein ligase TRIM11

2

2

Small-scale

0.601

High

228347

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

0

High-throughput

0.580

High

269350

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

276714

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

0

High-throughput

0.580

High

292387

RA51D
DNA repair protein RAD51 homolog 4

2

0

High-throughput

0.580

High

295996

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.580

High

334456

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.580

High

335496

SLU7
Pre-mRNA-splicing factor SLU7

2

0

High-throughput

0.580

High

348884

CLIC3
Chloride intracellular channel protein 3

2

0

High-throughput

0.580

High

349344

NUD14
Uridine diphosphate glucose pyrophosphatase NUDT14

2

0

High-throughput

0.580

High

473461

HCK
Tyrosine-protein kinase HCK

2

0

High-throughput

0.580

High

686755

CNTF
Ciliary neurotrophic factor

2

0

High-throughput

0.580

High

783377

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.580

High

862943

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

0

High-throughput

0.580

High

940462

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.580

High

954884

PSA6
Proteasome subunit alpha type-6

2

0

High-throughput

0.580

High

974270

LSM3
U6 snRNA-associated Sm-like protein LSm3

2

0

High-throughput

0.580

High

1006288

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

1014863

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

0

High-throughput

0.580

High

1095046

DUS4
Dual specificity protein phosphatase 4

2

0

High-throughput

0.580

High

1119775

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

0

High-throughput

0.580

High

1180803

KLH38
Kelch-like protein 38

2

0

High-throughput

0.580

High

1186691

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1196300

GRAP1
GRIP1-associated protein 1

2

0

High-throughput

0.580

High

1205944

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

0

High-throughput

0.580

High

1215574

B2L15
Bcl-2-like protein 15

2

0

High-throughput

0.580

High

1244638

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

1314908

CC146
Coiled-coil domain-containing protein 146

2

0

High-throughput

0.580

High

1315801

DZI1L
Cilium assembly protein DZIP1L

2

0

High-throughput

0.580

High

1332100

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.580

High

1335485

SEN2
tRNA-splicing endonuclease subunit Sen2

2

0

High-throughput

0.580

High

1347358

LMO3
LIM domain only protein 3

2

0

High-throughput

0.580

High

1352030

ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

2

0

High-throughput

0.580

High

1367897

THRSP
Thyroid hormone-inducible hepatic protein

2

0

High-throughput

0.580

High

1385734

BIRC7
Baculoviral IAP repeat-containing protein 7

2

0

High-throughput

0.580

High

1392848

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1398691

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

2

0

High-throughput

0.580

High

1398692

RAB3I
Rab-3A-interacting protein

2

0

High-throughput

0.580

High

1398698

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

2

0

High-throughput

0.580

High

1398701

APOL6
Apolipoprotein L6

2

0

High-throughput

0.580

High

1398706

B2L14
Apoptosis facilitator Bcl-2-like protein 14

2

0

High-throughput

0.580

High

1398710

DEFI6
Differentially expressed in FDCP 6 homolog

2

0

High-throughput

0.580

High

1398718

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

1398720

NGB
Neuroglobin

2

0

High-throughput

0.580

High

1398723

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1398725

MAT2B
Methionine adenosyltransferase 2 subunit beta

2

0

High-throughput

0.580

High

1398728

CPNE7
Copine-7

2

0

High-throughput

0.580

High

1398730

HSPB7
Heat shock protein beta-7

2

0

High-throughput

0.580

High

1398731

S14L4
SEC14-like protein 4

2

0

High-throughput

0.580

High

1398733

MLX
Max-like protein X

2

0

High-throughput

0.580

High

1398734

NDOR1
NADPH-dependent diflavin oxidoreductase 1

2

0

High-throughput

0.580

High

1398737

CDC23
Cell division cycle protein 23 homolog

2

0

High-throughput

0.580

High

1398738

OAZ3
Ornithine decarboxylase antizyme 3

2

0

High-throughput

0.580

High

1398744

ASB3
Ankyrin repeat and SOCS box protein 3

2

0

High-throughput

0.580

High

1398746

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

320260

SRBS2
Sorbin and SH3 domain-containing protein 2

2

1

High-throughput

0.553

High

350492

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

1

High-throughput

0.553

High

1240819

ZN343
Zinc finger protein 343

2

1

High-throughput

0.553

High

1271393

KCTD9
BTB/POZ domain-containing protein KCTD9

2

2

High-throughput

0.553

High

1398721

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.553

High

535423

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

1085102

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.536

High

1117917

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

2

High-throughput

0.536

High

1396892

KI16B
Kinesin-like protein KIF16B

1

1

High-throughput

0.536

High

515650

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.515

High

165640

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

462576

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.513

High

537729

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

552673

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.513

High

920204

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

1050512

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.513

High

1370990

TNPO1
Transportin-1

1

0

High-throughput

0.513

High

1398713

ZN703
Zinc finger protein 703

1

0

High-throughput

0.513

High

1398743

MMAC
Cyanocobalamin reductase / alkylcobalamin dealkylase

1

0

High-throughput

0.513

High

1277065

CC186
Coiled-coil domain-containing protein 186

1

1

High-throughput

0.489

High

1287723

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

1

High-throughput

0.489

High

515725

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.481

High

1398712

RANB3
Ran-binding protein 3

1

1

High-throughput

0.481

High

422919

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

173243

XPO1
Exportin-1

1

1

High-throughput

0.479

High

693913

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

1364523

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1398697

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1398711

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1398726

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.479

High

46790

A0A384ME25
Epididymis secretory sperm binding protein

1

1

High-throughput

0.470

High

1398735

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

107394

F8W6N3
Ubiquitin carboxyl-terminal hydrolase

1

1

High-throughput

0.445

High

107408

F8W7C6
Ribosomal protein L10

1

1

High-throughput

0.445

High

1040191

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

1

High-throughput

0.437

High

1105382

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.437

High

1398716

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.426

High

1398724

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.426

High

1398741

GUAD
Guanine deaminase

1

0

Small-scale

0.426

High

76662

B4E1G1
Derlin

1

1

High-throughput

0.407

High

91868

C9JWL4
AP-4 complex subunit mu-1

1

2

High-throughput

0.407

High

114527

H0YEX5
Splicing factor 3b subunit 2

1

1

High-throughput

0.407

High

116756

I3L1P8
Mitochondrial 2-oxoglutarate/malate carrier protein

1

1

High-throughput

0.407

High

913745

ZN140
Zinc finger protein 140

1

1

Small-scale

0.407

High

1334341

Q8NBY1
non-specific serine/threonine protein kinase

1

1

High-throughput

0.407

High

65886

MSGN1
Mesogenin-1

2

0

High-throughput

0.316

High

70429

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

136962

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

2

0

High-throughput

0.316

High

168312

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.316

High

171101

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.316

High

175510

KHNYN
Protein KHNYN

2

0

High-throughput

0.316

High

325224

OR6B1
Olfactory receptor 6B1

2

0

High-throughput

0.316

High

666890

CCNC
Cyclin-C

2

0

High-throughput

0.316

High

907878

CLCKA
Chloride channel protein ClC-Ka

2

0

High-throughput

0.316

High

935605

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.316

High

938493

PAX9
Paired box protein Pax-9

2

0

High-throughput

0.316

High

1063542

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.316

High

1150161

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

1152346

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

2

0

High-throughput

0.316

High

1198272

FND3B
Fibronectin type III domain-containing protein 3B

2

0

High-throughput

0.316

High

1211536

SZT2
KICSTOR complex protein SZT2

2

0

High-throughput

0.316

High

1224704

TSH3
Teashirt homolog 3

2

0

High-throughput

0.316

High

1225863

WDR25
WD repeat-containing protein 25

2

0

High-throughput

0.316

High

1251943

LMTK1
Serine/threonine-protein kinase LMTK1

2

0

High-throughput

0.316

High

1272344

ATOSB
Atos homolog protein B

2

0

High-throughput

0.316

High

1280271

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

1286404

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.316

High

1292638

NR2CA
Nuclear receptor 2C2-associated protein

2

0

High-throughput

0.316

High

1295089

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1329592

ACBD7
Acyl-CoA-binding domain-containing protein 7

2

0

High-throughput

0.316

High

1349649

PPL13
Placental protein 13-like

2

0

High-throughput

0.316

High

1358899

SEN15
tRNA-splicing endonuclease subunit Sen15

2

0

High-throughput

0.316

High

1385249

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

1398689

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1398690

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1398694

UTP23
rRNA-processing protein UTP23 homolog

2

0

High-throughput

0.316

High

1398695

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

High-throughput

0.316

High

1398699

CINP
Cyclin-dependent kinase 2-interacting protein

2

0

High-throughput

0.316

High

1398702

TPSNR
Tapasin-related protein

2

0

High-throughput

0.316

High

1398703

C1QT4
Complement C1q tumor necrosis factor-related protein 4

2

0

High-throughput

0.316

High

1398708

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1398717

CBX8
Chromobox protein homolog 8

2

0

High-throughput

0.316

High

1398719

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1398727

GBG13

2

0

High-throughput

0.316

High

1398729

MO4L1
Mortality factor 4-like protein 1

2

0

High-throughput

0.316

High

1398732

ZN629
Zinc finger protein 629

2

0

High-throughput

0.316

High

1398747

PCDB3
Protocadherin beta-3

2

0

High-throughput

0.316

High

286036

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.279

Low

663825

LAMA2
Laminin subunit alpha-2

1

0

High-throughput

0.279

Low

1023150

RBM10
RNA-binding protein 10

1

0

High-throughput

0.279

Low

1149162

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.279

Low

1200107

UNC50
Protein unc-50 homolog

1

0

High-throughput

0.279

Low

1260717

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

0

High-throughput

0.279

Low

1281667

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.279

Low

1398693

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.279

Low

1398709

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.279

Low

1398736

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.279

Low

1398742

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.279

Low

1398748

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

959517

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

282533

PAGE1
P antigen family member 1

1

0

Small-scale

0.232

Low

427927

ICAM1
Intercellular adhesion molecule 1

1

0

Small-scale

0.232

Low

1135270

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

0

Small-scale

0.232

Low

1306938

TMPS6
Transmembrane protease serine 6

1

0

Small-scale

0.232

Low

1358251

ANR49
Ankyrin repeat domain-containing protein 49

1

0

Small-scale

0.232

Low

1398700

SCNM1
Sodium channel modifier 1

1

0

Small-scale

0.232

Low

1398707

IQCN
IQ domain-containing protein N

1

0

Small-scale

0.232

Low

1398750

RM42
Large ribosomal subunit protein mL42

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025