Protein: MIA40
Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)

Gene: MIA40, CHCHD4
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q8N4Q1

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space
GO:0015035 - protein-disulfide reductase activity
GO:0033108 - mitochondrial respiratory chain complex assembly
GO:0045041 - protein import into mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348612

AIFM1
Apoptosis-inducing factor 1, mitochondrial

5

0

High-throughput

0.676

High

1326734

CHCH5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5

1

0

High-throughput

0.656

High

576121

CX6B1
Cytochrome c oxidase subunit 6B1

3

2

High-throughput

0.650

High

938664

ALR
FAD-linked sulfhydryl oxidase ALR

3

1

Small-scale

0.643

High

967266

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

3

2

Small-scale

0.643

High

1326722

COA7
Cytochrome c oxidase assembly factor 7

3

0

Small-scale

0.616

High

907165

SUOX
Sulfite oxidase, mitochondrial

2

1

High-throughput

0.601

High

505446

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

2

0

High-throughput

0.585

High

333583

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

2

0

High-throughput

0.576

High

462790

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.576

High

1225005

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.576

High

1326721

CC127
Coiled-coil domain-containing protein 127

2

0

Small-scale

0.576

High

1326750

MOCS1
Molybdenum cofactor biosynthesis protein 1

2

0

High-throughput

0.576

High

1326743

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

1315576

MICU2
Calcium uptake protein 2, mitochondrial

1

2

High-throughput

0.536

High

1326732

MICU1
Calcium uptake protein 1, mitochondrial

1

2

Small-scale

0.536

High

1326740

ADT4
ADP/ATP translocase 4

1

3

High-throughput

0.536

High

1326760

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

2

High-throughput

0.536

High

1196939

MIX23
Protein MIX23

2

0

Small-scale

0.528

High

1120096

COX17
Cytochrome c oxidase copper chaperone

1

0

Small-scale

0.527

High

231245

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.513

High

245497

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.513

High

528300

THIO
Thioredoxin

1

0

High-throughput

0.513

High

605471

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.513

High

641805

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

663367

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

724128

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.513

High

1240305

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

1292951

COA5
Cytochrome c oxidase assembly factor 5

1

0

High-throughput

0.513

High

1310225

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1326756

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.513

High

343614

OXSR1
Serine/threonine-protein kinase OSR1

1

1

High-throughput

0.489

High

1033384

CDR2
Cerebellar degeneration-related protein 2

1

1

High-throughput

0.489

High

1292997

CDR2L
Cerebellar degeneration-related protein 2-like

1

1

High-throughput

0.489

High

1326741

WNK1
Serine/threonine-protein kinase WNK1

1

1

High-throughput

0.489

High

1326752

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

1

High-throughput

0.489

High

1232761

CPIN1
Anamorsin

1

0

Small-scale

0.480

High

292172

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

1326715

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

2

High-throughput

0.479

High

935917

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.460

High

296268

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

521390

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.458

High

1013417

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1098727

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.458

High

1326712

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

0

High-throughput

0.458

High

1326720

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1326728

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

1326729

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

1326731

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

1326735

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1326737

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.458

High

1326744

SUCHY
Succinyl-CoA:glutarate CoA-transferase

1

0

High-throughput

0.458

High

1326747

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

238722

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

3

Small-scale

0.445

High

1235720

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

2

High-throughput

0.445

High

1326739

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.445

High

1326759

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

3

Small-scale

0.445

High

827228

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.437

High

1252441

M3K15
Mitogen-activated protein kinase kinase kinase 15

1

1

High-throughput

0.437

High

124405

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.426

High

132864

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

0

High-throughput

0.426

High

353957

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

Small-scale

0.426

High

471130

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.426

High

932487

KAD2
Adenylate kinase 2, mitochondrial

1

0

Small-scale

0.426

High

1326723

F136A
Protein FAM136A

1

0

High-throughput

0.426

High

1326724

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.426

High

1326726

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.426

High

1326753

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.426

High

1326746

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.407

High

1206856

TOIP1
Torsin-1A-interacting protein 1

3

0

High-throughput

0.345

High

228037

SSNA1
Microtubule nucleation factor SSNA1

3

0

Small-scale

0.335

High

1326749

MED29
Mediator of RNA polymerase II transcription subunit 29

3

0

Small-scale

0.335

High

226982

ENSA
Alpha-endosulfine

2

0

High-throughput

0.313

High

1155304

VPS72
Vacuolar protein sorting-associated protein 72 homolog

2

0

High-throughput

0.313

High

1194691

GXLT1
Glucoside xylosyltransferase 1

2

0

High-throughput

0.313

High

1273846

MICA3
[F-actin]-monooxygenase MICAL3

2

0

High-throughput

0.313

High

1326717

RAD50
DNA repair protein RAD50

2

0

High-throughput

0.313

High

1326733

KLDC3
Kelch domain-containing protein 3

2

0

High-throughput

0.313

High

1102345

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.298

High

231728

PEX1
Peroxisomal ATPase PEX1

1

0

High-throughput

0.279

Low

287711

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.279

Low

860836

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.279

Low

909095

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.279

Low

987412

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.279

Low

1004283

F193A
Protein FAM193A

1

0

High-throughput

0.279

Low

1119849

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.279

Low

1156545

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.279

Low

1249895

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.279

Low

1280952

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.279

Low

1292165

LIPB1
Liprin-beta-1

1

0

High-throughput

0.279

Low

1316032

TRM2A
tRNA

1

0

High-throughput

0.279

Low

1316172

DCP1B
mRNA-decapping enzyme 1B

1

0

High-throughput

0.279

Low

1326711

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.279

Low

1326713

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

High-throughput

0.279

Low

1326714

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.279

Low

1326725

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

High-throughput

0.279

Low

1326727

VPS39
Vam6/Vps39-like protein

1

0

High-throughput

0.279

Low

1326738

Z518B
Zinc finger protein 518B

1

0

High-throughput

0.279

Low

1326742

WDR54
WD repeat-containing protein 54

1

0

High-throughput

0.279

Low

1326745

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.279

Low

1326748

SLTM
SAFB-like transcription modulator

1

0

High-throughput

0.279

Low

1326751

ZN581
Zinc finger protein 581

1

0

High-throughput

0.279

Low

1326754

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.279

Low

1326757

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.279

Low

1326761

CMTA1
Calmodulin-binding transcription activator 1

1

0

High-throughput

0.279

Low

641624

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

0

High-throughput

0.261

Low

1326736

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

136936

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

294010

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

372570

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

447216

NPM
Nucleophosmin

1

0

High-throughput

0.249

Low

847597

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

901936

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.249

Low

957438

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.249

Low

970773

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1052840

DUSP2
Dual specificity protein phosphatase 2

1

0

High-throughput

0.249

Low

1218345

OTUD1
OTU domain-containing protein 1

1

0

Small-scale

0.249

Low

250704

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.232

Low

933262

AIF1
Allograft inflammatory factor 1

1

0

Small-scale

0.232

Low

993434

ACTH
Actin, gamma-enteric smooth muscle

1

0

Small-scale

0.232

Low

1039967

AKA12
A-kinase anchor protein 12

1

0

Small-scale

0.232

Low

1086634

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.232

Low

1112915

CUL2
Cullin-2

1

0

High-throughput

0.232

Low

1129247

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.232

Low

1144287

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.232

Low

1154540

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.232

Low

1163930

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.232

Low

1249922

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

0

High-throughput

0.232

Low

1309932

MA7D3
MAP7 domain-containing protein 3

1

0

Small-scale

0.232

Low

1326716

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.232

Low

1326718

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

0

High-throughput

0.232

Low

1326719

C102A
Coiled-coil domain-containing protein 102A

1

0

High-throughput

0.232

Low

1326730

FACOS
FANCD2 opposite strand protein

1

0

High-throughput

0.232

Low

1326755

SH2B3
SH2B adapter protein 3

1

0

High-throughput

0.232

Low

1326758

KLK5
Kallikrein-5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025