HitPredict

Interactor 1: CXCL7 (P02775)
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Gene: PPBP

Interactor 2: CCL8 (P80075)
C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
Gene: CCL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 99
+	Hs
		364057 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25
+	Hs
		364036 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		364065 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CCL26_HUMAN (23-95): 4.79e-23: 86.6: 35.62
+	Hs
		134283 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CCL21_HUMAN (24-99): 2.47e-21: 83.1: 32.91
+	Hs
		587776 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00
+	Hs
		945619 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00
+	Hs
		791124 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CCL11_HUMAN (1-99): 2.27e-31: 107: 68.69
+	Hs
		945626 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CCL7_HUMAN (17-98): 4.92e-33: 111: 62.20
+	Hs
		587775 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CCL11_HUMAN (1-99): 2.27e-31: 107: 68.69
+	Hs
		587789 CXCL3_HUMAN (57-127): 1.67e-26: 96.7: 50.70		CCL11_HUMAN (1-99): 2.27e-31: 107: 68.69
+	Hs
		849510 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CCL11_HUMAN (1-99): 2.27e-31: 107: 68.69
+	Hs
		448992 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		CCL11_HUMAN (1-99): 2.27e-31: 107: 68.69
+	Hs
		528237 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		791136 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		XCL2_HUMAN (7-97): 1.91e-23: 88.1: 29.67
+	Hs
		528257 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		587772 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		XCL1_HUMAN (7-97): 1.01e-23: 88.9: 29.67
+	Hs
		587784 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		XCL2_HUMAN (7-97): 1.91e-23: 88.1: 29.67
+	Hs
		587795 CXCL3_HUMAN (57-127): 1.67e-26: 96.7: 50.70		XCL2_HUMAN (7-97): 1.91e-23: 88.1: 29.67
+	Hs
		134290 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CCL21_HUMAN (24-99): 2.47e-21: 83.1: 32.91
+	Hs
		791125 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CCL20_HUMAN (5-97): 3.28e-20: 79.2: 26.60