Protein: DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase DOA10)

Gene: DOA10, SSM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P40318

Gene Ontology (top 5):
GO:0000837 - Doa10p ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771583

UBC7
Ubiquitin-conjugating enzyme E2 7

9

20

Small-scale

0.754

High

703552

UBC6
Ubiquitin-conjugating enzyme E2 6

7

20

Small-scale

0.743

High

636643

CDC48
Cell division control protein 48

6

5

Small-scale

0.729

High

771588

UBX2
UBX domain-containing protein 2

5

0

Small-scale

0.690

High

750085

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

5

0

Small-scale

0.682

High

477312

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

5

Small-scale

0.602

High

771554

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

2

11

Small-scale

0.602

High

522421

STE6
Alpha-factor-transporting ATPase

2

2

Small-scale

0.567

High

771577

PDR18
ABC transporter ATP-binding protein/permease PDR18

1

2

High-throughput

0.541

High

771572

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.530

High

771586

NHX1
Endosomal/prevacuolar sodium/hydrogen exchanger

1

0

High-throughput

0.518

High

771557

SYA
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.501

High

771559

MVP1
Sorting nexin MVP1

1

1

High-throughput

0.501

High

771567

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.501

High

771589

HFD1
Fatty aldehyde dehydrogenase HFD1

1

4

High-throughput

0.501

High

771598

LKHA4
Leucine aminopeptidase 2

1

1

High-throughput

0.501

High

771569

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.481

High

333977

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.480

High

440152

ERG20
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.480

High

572788

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.480

High

634339

POF1
Nicotinamide mononucleotide adenylyltransferase

1

0

High-throughput

0.480

High

771590

SEC13
Protein transport protein SEC13

1

0

High-throughput

0.480

High

771591

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.480

High

771595

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

High-throughput

0.480

High

771570

SC6B2
Protein transport protein SBH2

1

1

Small-scale

0.479

High

771599

DFM1
DER1-like family member protein 1

1

1

Small-scale

0.479

High

749122

ATU1
P-type cation-transporting ATPase

1

1

Small-scale

0.470

High

771571

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.460

High

608467

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

688067

VPH2
Vacuolar ATPase assembly integral membrane protein VPH2

1

0

Small-scale

0.458

High

701458

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.458

High

707234

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.458

High

732298

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

771584

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.458

High

771594

PEX15
Peroxisomal membrane protein PEX15

1

0

Small-scale

0.458

High

342940

ENO2
Enolase 2

1

2

High-throughput

0.457

High

494113

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.457

High

625976

PTP1
Tyrosine-protein phosphatase 1

1

9

High-throughput

0.457

High

634090

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

698827

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.457

High

704894

LHP1
La protein homolog

1

1

High-throughput

0.457

High

745076

MAL32
Alpha-glucosidase MAL32

1

3

High-throughput

0.457

High

753116

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

1

High-throughput

0.457

High

771564

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

771568

SOL1
6-phosphogluconolactonase-like protein 1

1

1

High-throughput

0.457

High

771573

MALX3
Oligo-1,6-glucosidase IMA1

1

3

High-throughput

0.457

High

771574

STR3
Cystathionine beta-lyase

1

1

High-throughput

0.457

High

771575

YGD9
Putative uncharacterized oxidoreductase YGL039W

1

2

High-throughput

0.457

High

771579

YL460
Uncharacterized protein YLR460C

1

2

High-throughput

0.457

High

771580

PROA
Gamma-glutamyl phosphate reductase

1

4

High-throughput

0.457

High

771582

CTF4
DNA polymerase alpha-binding protein

1

1

High-throughput

0.457

High

771600

YPT6
GTP-binding protein YPT6

1

3

High-throughput

0.457

High

543843

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

703909

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

Small-scale

0.437

High

758666

TEM1
Protein TEM1

1

2

High-throughput

0.437

High

694808

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

757280

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

Small-scale

0.407

High

771556

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.391

High

478765

ERR1
Enolase-related protein 1

1

2

High-throughput

0.373

High

341805

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.261

Low

417586

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.261

Low

488466

YEY2
Uncharacterized protein YER152C

1

0

High-throughput

0.261

Low

501291

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.261

Low

505162

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.261

Low

546529

AMPD
AMP deaminase

1

0

High-throughput

0.261

Low

555756

THRC
Threonine synthase

1

0

High-throughput

0.261

Low

560457

PDC5
Pyruvate decarboxylase isozyme 2

1

0

High-throughput

0.261

Low

562394

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

564306

RL8A
Large ribosomal subunit protein eL8A

1

0

High-throughput

0.261

Low

599182

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.261

Low

618233

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.261

Low

635127

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.261

Low

677520

MLS1
Malate synthase 1

1

0

High-throughput

0.261

Low

680755

HS104
Heat shock protein 104

1

0

High-throughput

0.261

Low

686965

GLNA
Glutamine synthetase

1

0

High-throughput

0.261

Low

716117

THI80
Thiamine pyrophosphokinase

1

0

High-throughput

0.261

Low

740811

ADCS
Aminodeoxychorismate synthase

1

0

High-throughput

0.261

Low

742716

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.261

Low

743943

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.261

Low

753219

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.261

Low

753755

TDA3
Putative oxidoreductase TDA3

1

0

High-throughput

0.261

Low

754392

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.261

Low

758938

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.261

Low

759362

STM1
Suppressor protein STM1

1

0

High-throughput

0.261

Low

763262

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.261

Low

770503

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.261

Low

771555

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.261

Low

771558

YJV8
Putative acetyltransferase YJL218W

1

0

High-throughput

0.261

Low

771561

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

771562

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.261

Low

771563

MTHR1
Methylenetetrahydrofolate reductase 1

1

0

High-throughput

0.261

Low

771565

AIP1
Actin-interacting protein 1

1

0

High-throughput

0.261

Low

771566

YJ66
Uncharacterized oxidoreductase YJR096W

1

0

High-throughput

0.261

Low

771576

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.261

Low

771578

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.261

Low

771581

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.261

Low

771587

ARA2
D-arabinose 1-dehydrogenase

1

0

High-throughput

0.261

Low

771592

KYNU
Kynureninase

1

0

High-throughput

0.261

Low

771593

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

771596

THTR
Thiosulfate sulfurtransferase TUM1

1

0

High-throughput

0.261

Low

771597

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.261

Low

524331

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

605540

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.249

Low

662386

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

689766

MFAL2
Mating factor alpha-2

1

0

Small-scale

0.249

Low

771560

PRP17
Pre-mRNA-processing factor 17

1

0

Small-scale

0.249

Low

771585

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024