Protein: SURF1
Surfeit locus protein 1

Gene: SURF1
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q15526

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0008535 - respiratory chain complex IV assembly
GO:0009060 - aerobic respiration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888519

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

4

1

High-throughput

0.687

High

559966

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.585

High

1149649

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

2

0

Small-scale

0.585

High

485867

COX6C
Cytochrome c oxidase subunit 6C

2

0

Small-scale

0.547

High

1149598

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1149630

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

634760

GRAH
Granzyme H

1

1

High-throughput

0.489

High

996961

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.489

High

1149590

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.489

High

1149616

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

1149621

TBB6
Tubulin beta-6 chain

1

1

High-throughput

0.489

High

281593

MTX2
Metaxin-2

1

1

High-throughput

0.479

High

298719

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.479

High

360422

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.479

High

522430

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

528453

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.479

High

552012

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.479

High

634114

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

733934

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.479

High

766582

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

788036

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

888710

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

1

High-throughput

0.479

High

1035394

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

High-throughput

0.479

High

1108423

MTX1
Metaxin-1

1

1

High-throughput

0.479

High

1138836

SYLM
Leucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1141489

OXA1L
Mitochondrial inner membrane protein OXA1L

1

1

High-throughput

0.479

High

1149577

SYVM
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1149578

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.479

High

1149585

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

1149591

ACOT1
Acyl-coenzyme A thioesterase 1

1

1

High-throughput

0.479

High

1149597

S2540
Mitochondrial glutathione transporter SLC25A40

1

1

High-throughput

0.479

High

1149605

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.479

High

1149611

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

1149612

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1149617

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.479

High

1149633

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1149638

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1149639

DJC11
DnaJ homolog subfamily C member 11

1

3

High-throughput

0.479

High

1149640

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.479

High

1149642

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.479

High

1149656

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

71734

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.458

High

75963

B4DEF8
Large ribosomal subunit protein mL45

1

0

High-throughput

0.458

High

124355

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

127497

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.458

High

143847

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.458

High

1149619

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1149620

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.458

High

209775

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.458

High

221586

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.458

High

223831

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.458

High

231229

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.458

High

256303

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.458

High

269015

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

0

High-throughput

0.458

High

275296

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.458

High

275664

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.458

High

278668

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.458

High

279769

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

283865

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

296243

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

322244

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.458

High

328535

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.458

High

329269

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

353940

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.458

High

443801

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.458

High

551658

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.458

High

553824

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

568423

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

572360

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.458

High

576107

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

590371

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.458

High

617519

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

622170

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.458

High

665601

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.458

High

702591

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.458

High

717090

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

719436

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

0

High-throughput

0.458

High

724084

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

760925

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

793707

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

841750

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

856269

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

890959

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

902481

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.458

High

909436

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

914619

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.458

High

940008

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.458

High

941662

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.458

High

1011091

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.458

High

1011273

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.458

High

1011615

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.458

High

1011800

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.458

High

1012056

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.458

High

1012508

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.458

High

1012697

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

1012843

RT09
Small ribosomal subunit protein uS9m

1

0

High-throughput

0.458

High

1013391

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1038626

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.458

High

1087398

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1103969

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.458

High

1104719

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1149574

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.458

High

1149575

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

1149576

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1149579

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1149581

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.458

High

1149582

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.458

High

1149584

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1149588

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.458

High

1149589

PTAR1
Protein prenyltransferase alpha subunit repeat-containing protein 1

1

0

High-throughput

0.458

High

1149593

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.458

High

1149594

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.458

High

1149595

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

0

High-throughput

0.458

High

1149599

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

1149601

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

1149602

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.458

High

1149603

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1149604

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.458

High

1149606

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

1149607

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.458

High

1149608

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.458

High

1149613

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.458

High

1149614

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.458

High

1149615

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.458

High

1149618

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1149623

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.458

High

1149624

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

1149626

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1149627

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.458

High

1149631

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.458

High

1149634

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.458

High

1149635

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.458

High

1149637

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.458

High

1149641

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1149643

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.458

High

1149644

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.458

High

1149646

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.458

High

1149647

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.458

High

1149648

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.458

High

1149650

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.458

High

1149651

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.458

High

1149652

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.458

High

1149653

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.458

High

1149654

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.458

High

1149655

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

1149657

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

1149658

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.458

High

1149659

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.458

High

1149632

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.445

High

258891

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.437

High

299206

FLOT1
Flotillin-1

1

2

High-throughput

0.437

High

1124815

FLOT2
Flotillin-2

1

2

High-throughput

0.437

High

1149609

COX14
Cytochrome c oxidase assembly protein COX14

1

0

Small-scale

0.426

High

1149629

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.426

High

437681

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

457458

TBB5
Tubulin beta chain

1

1

High-throughput

0.407

High

378319

IFNA5
Interferon alpha-5

3

0

High-throughput

0.347

High

1149610

GBP5
Guanylate-binding protein 5

2

0

High-throughput

0.328

High

1149622

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

0

High-throughput

0.328

High

1143999

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.282

High

182543

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

260866

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

469486

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

568061

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.279

Low

705859

DHI1
11-beta-hydroxysteroid dehydrogenase 1

1

0

High-throughput

0.279

Low

749332

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

848489

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

867619

GPR12
G-protein coupled receptor 12

1

0

High-throughput

0.279

Low

1085944

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.279

Low

1149580

OBSCN
Obscurin

1

0

High-throughput

0.279

Low

1149586

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

0

High-throughput

0.279

Low

1149600

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1149625

CDHR2
Cadherin-related family member 2

1

0

High-throughput

0.279

Low

1149628

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.279

Low

1149645

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

451164

NFL
Neurofilament light polypeptide

1

0

High-throughput

0.249

Low

1149583

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1149660

PCLO
Protein piccolo

1

0

High-throughput

0.249

Low

342567

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

388630

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.232

Low

679342

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.232

Low

845031

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.232

Low

1149587

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.232

Low

1149592

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

0

High-throughput

0.232

Low

1149596

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.232

Low

1149636

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025