Protein: GBP1
Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1)

Gene: GBP1
Organism: Homo sapiens
Interactions: 38
UniProt ID: P32455

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001530 - lipopolysaccharide binding
GO:0003779 - actin binding
GO:0003924 - GTPase activity
GO:0003925 - G protein activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

736877

GBP1
Guanylate-binding protein 1

4

14

Small-scale

0.912

High

736894

GBP3
Guanylate-binding protein 3

4

14

Small-scale

0.900

High

736878

GBP2
Guanylate-binding protein 2

3

14

Small-scale

0.867

High

736890

GBP5
Guanylate-binding protein 5

3

14

Small-scale

0.867

High

736891

GBP4
Guanylate-binding protein 4

1

14

Small-scale

0.665

High

736889

RNF31
E3 ubiquitin-protein ligase RNF31

2

1

High-throughput

0.628

High

395580

ESR1
Estrogen receptor

2

0

High-throughput

0.602

High

736881

AFAM
Afamin

2

0

High-throughput

0.602

High

736880

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

2

Small-scale

0.584

High

736879

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

736898

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

736902

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

594829

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

736883

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

736885

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

736897

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.513

High

736901

CTNA3
Catenin alpha-3

1

0

High-throughput

0.513

High

425342

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

533887

IRF1
Interferon regulatory factor 1

1

9

Small-scale

0.479

High

571560

IRF2
Interferon regulatory factor 2

1

9

Small-scale

0.479

High

679078

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.479

High

685422

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

736882

STAT2
Signal transducer and activator of transcription 2

1

2

Small-scale

0.479

High

736884

IRF9
Interferon regulatory factor 9

1

9

Small-scale

0.479

High

736887

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

736900

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

358622

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.458

High

464835

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

736893

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.458

High

736895

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

736896

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

563294

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

261104

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

736899

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

2

0

High-throughput

0.324

High

736886

FAH2B
Oxaloacetate tautomerase FAHD2B, mitochondrial

1

0

High-throughput

0.279

Low

736892

ZN317
Zinc finger protein 317

1

0

High-throughput

0.279

Low

736888

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025