Protein: MGMT
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (DNA repair MTase) (O-6-methylguanine-DNA-alkyltransferase)

Gene: MGMT, MGT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P26188

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005634 - nucleus
GO:0006307 - DNA alkylation repair
GO:0032259 - methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640306

UFD4
Ubiquitin fusion degradation protein 4

2

0

Small-scale

0.612

High

355372

H2B1
Histone H2B.1

1

1

High-throughput

0.536

High

640315

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.536

High

640322

H3
Histone H3

1

2

High-throughput

0.536

High

540535

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

454209

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.500

High

636542

CDC48
Cell division control protein 48

1

1

High-throughput

0.500

High

640313

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.500

High

640321

ACT
Actin

1

1

High-throughput

0.500

High

640309

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.489

High

381431

GAL1
Galactokinase

1

0

High-throughput

0.479

High

439984

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.479

High

554576

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

632984

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

640304

RPN2
26S proteasome regulatory subunit RPN2

1

0

High-throughput

0.479

High

640323

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

640326

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.479

High

341947

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.457

High

360763

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

397581

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.457

High

423780

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.457

High

555853

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.457

High

587963

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.457

High

619535

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.457

High

640305

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

490497

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

510446

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

477956

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

543298

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

587291

UBR1
E3 ubiquitin-protein ligase UBR1

3

0

Small-scale

0.349

High

435453

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

503056

ARF1
ADP-ribosylation factor 1

1

0

High-throughput

0.279

Low

640307

DCA13
Protein SOF1

1

0

High-throughput

0.279

Low

640308

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.279

Low

640310

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.279

Low

640311

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.279

Low

640312

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.279

Low

640314

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.279

Low

640317

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

640319

GPG1
Heterotrimeric G protein gamma subunit GPG1

1

0

High-throughput

0.279

Low

640320

EF3B
Elongation factor 3B

1

0

High-throughput

0.279

Low

640325

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.279

Low

343548

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

389240

HXKA
Hexokinase-1

1

0

High-throughput

0.261

Low

421584

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

424372

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.261

Low

498451

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

520928

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

549651

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

562332

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

604357

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

640316

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

640318

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.261

Low

640324

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

0

High-throughput

0.261

Low

604251

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024