Protein: SP110
Spindle pole body component 110 (Extragenic suppressor of CMD1-1 mutant protein 1) (Nuclear filament-related protein 1) (Spindle pole body spacer protein SPC110)

Gene: SP110, SPC110
Organism: Saccharomyces cerevisiae S288C
Interactions: 131
UniProt ID: P32380

Gene Ontology (top 5):
GO:0000022 - mitotic spindle elongation
GO:0000742 - karyogamy involved in conjugation with cellular fusion
GO:0005200 - structural constituent of cytoskeleton
GO:0005516 - calmodulin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449089

CALM
Calmodulin

11

4

Small-scale

0.976

High

736001

SPC97
Spindle pole body component SPC97

8

1

Small-scale

0.753

High

736029

TBG
Tubulin gamma chain

8

8

Small-scale

0.752

High

736030

SPC98
Spindle pole body component SPC98

7

1

Small-scale

0.750

High

735973

SP110
Spindle pole body component 110

7

19

Small-scale

0.742

High

445323

CDC31
Cell division control protein 31

1

5

Small-scale

0.724

High

735988

SPC42
Spindle pole body component SPC42

11

0

Small-scale

0.724

High

736033

CNM67
Chaotic nuclear migration protein 67

6

17

Small-scale

0.721

High

735985

SPC29
Spindle pole component 29

8

0

Small-scale

0.719

High

364406

CDK1
Cyclin-dependent kinase 1

5

15

Small-scale

0.718

High

736036

MPS1
Serine/threonine-protein kinase MPS1

3

20

Small-scale

0.664

High

736013

MLP2
Protein MLP2

4

20

Small-scale

0.627

High

736037

CDC14
Tyrosine-protein phosphatase CDC14

2

14

Small-scale

0.619

High

523341

HSP71
Heat shock protein SSA1

3

12

Small-scale

0.611

High

734591

NUD1
Protein NUD1

3

11

Small-scale

0.578

High

544144

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

Small-scale

0.552

High

736040

LGE1
Transcriptional regulatory protein LGE1

2

0

High-throughput

0.547

High

448857

STE7
Serine/threonine-protein kinase STE7

1

20

High-throughput

0.536

High

735981

SWE1
Mitosis inhibitor protein kinase SWE1

1

20

High-throughput

0.536

High

735997

MSG5
Tyrosine-protein phosphatase MSG5

1

12

High-throughput

0.536

High

736006

MBO1
Gamma tubulin complex adapter SPC72

2

0

Small-scale

0.528

High

736046

SPC24
Kinetochore protein SPC24

2

0

Small-scale

0.528

High

736003

SAK1
SNF1-activating kinase 1

1

0

High-throughput

0.513

High

736027

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

1

0

High-throughput

0.513

High

736049

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.513

High

736020

STU2
Protein STU2

2

6

Small-scale

0.504

High

721769

XPO1
Exportin-1

1

7

Small-scale

0.481

High

736034

AF9
Protein AF-9 homolog

1

1

High-throughput

0.481

High

736059

GYP5
GTPase-activating protein GYP5

1

3

High-throughput

0.481

High

416207

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

417052

VDAC1
Non-selective voltage-gated ion channel 1

1

3

High-throughput

0.479

High

470741

GPA1
Guanine nucleotide-binding protein alpha-1 subunit

1

6

Small-scale

0.479

High

560232

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.479

High

581837

SYKC
Lysine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

706479

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

735976

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

12

Small-scale

0.479

High

735998

RCK2
Serine/threonine-protein kinase RCK2

1

3

High-throughput

0.479

High

735999

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

736031

PDR16
Phosphatidylinositol transfer protein PDR16

1

3

High-throughput

0.479

High

736035

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

736052

LAM6
Membrane-anchored lipid-binding protein LAM6

1

3

High-throughput

0.479

High

736055

ESA1
Histone acetyltransferase ESA1

1

3

Small-scale

0.479

High

736058

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

736062

NAA25
N-terminal acetyltransferase B complex subunit MDM20

1

1

High-throughput

0.479

High

672382

STE50
Protein STE50

1

0

High-throughput

0.460

High

735982

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

735994

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

736022

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

150271

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

576950

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.458

High

632321

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

671916

RBSK
Ribokinase

1

0

High-throughput

0.458

High

735980

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

736007

SS120
Protein SSP120

1

0

High-throughput

0.458

High

736011

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

736015

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

736016

RTS2
Zinc finger protein RTS2

1

0

High-throughput

0.458

High

736045

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

736047

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.458

High

736048

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.458

High

736054

SGO1
Shugoshin

1

0

High-throughput

0.458

High

736061

SFI1
Protein SFI1

1

0

Small-scale

0.458

High

736066

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.458

High

381943

H4
Histone H4

1

12

Small-scale

0.445

High

386623

TBB
Tubulin beta chain

1

3

Small-scale

0.445

High

392403

HSP82
ATP-dependent molecular chaperone HSP82

1

16

High-throughput

0.445

High

401926

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.445

High

481531

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.445

High

486085

TBA1
Tubulin alpha-1 chain

1

4

Small-scale

0.445

High

526162

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

575908

CYPH
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.445

High

602035

KAR3
Kinesin-like protein KAR3

1

10

Small-scale

0.445

High

656945

BUR1
Serine/threonine-protein kinase BUR1

1

20

Small-scale

0.445

High

675807

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

686880

BUB2
Mitotic check point protein BUB2

1

4

High-throughput

0.445

High

704860

KIP1
Kinesin-like protein KIP1

1

6

Small-scale

0.445

High

735975

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

5

High-throughput

0.445

High

735984

DOM34
Protein DOM34

1

2

Small-scale

0.445

High

735986

NUF2
Kinetochore protein NUF2

1

16

Small-scale

0.445

High

735993

STU1
Protein STU1

1

3

Small-scale

0.445

High

736002

SET5
Histone-lysine N-methyltransferase SET5

1

2

High-throughput

0.445

High

736008

HSP7E
Heat shock protein SSC3, mitochondrial

1

13

High-throughput

0.445

High

736012

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

736014

NDC80
Kinetochore protein NDC80

1

19

Small-scale

0.445

High

736032

JJJ1
J protein JJJ1

1

10

High-throughput

0.445

High

736041

HOS3
Histone deacetylase HOS3

1

20

High-throughput

0.445

High

736050

BRE1
E3 ubiquitin-protein ligase BRE1

1

18

High-throughput

0.445

High

736065

APC2
Anaphase-promoting complex subunit 2

1

17

Small-scale

0.445

High

560789

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.437

High

735977

SNQ2
Protein SNQ2

1

3

High-throughput

0.437

High

735983

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

High-throughput

0.437

High

735992

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

2

High-throughput

0.437

High

736004

ATU2
Copper-transporting ATPase

1

3

High-throughput

0.437

High

736018

EMP47
Protein EMP47

1

1

High-throughput

0.437

High

736026

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

736028

MTM1
Mitochondrial carrier protein MTM1

1

7

High-throughput

0.437

High

736039

KIN4
Serine/threonine-protein kinase KIN4

1

10

Small-scale

0.437

High

736042

ESC1
Silent chromatin protein ESC1

1

8

High-throughput

0.437

High

736063

DBP10
ATP-dependent RNA helicase DBP10

1

11

High-throughput

0.437

High

736064

EMP46
Protein EMP46

1

4

High-throughput

0.437

High

735974

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

735989

SPC34
DASH complex subunit SPC34

1

0

Small-scale

0.426

High

735995

CENPL
Inner kinetochore subunit IML3

1

0

High-throughput

0.426

High

736010

SPC25
Kinetochore protein SPC25

1

0

Small-scale

0.426

High

736023

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

Small-scale

0.426

High

736044

SPC19
DASH complex subunit SPC19

1

0

Small-scale

0.426

High

736051

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

736060

BBP1
Spindle pole component BBP1

1

0

Small-scale

0.426

High

735987

NIC96
Nucleoporin NIC96

1

1

Small-scale

0.407

High

736000

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

3

Small-scale

0.407

High

736009

BIM1
Protein BIM1

1

5

Small-scale

0.407

High

736057

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.279

Low

736021

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

448887

TYSY
Thymidylate synthase

1

0

High-throughput

0.249

Low

637319

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

644675

ATP12
Protein ATP12, mitochondrial

1

0

High-throughput

0.249

Low

735979

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

735990

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

735991

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

735996

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

736017

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.249

Low

736025

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

736038

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.249

Low

736043

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

736053

ENB1
Siderophore iron transporter ENB1

1

0

High-throughput

0.249

Low

736056

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.249

Low

735978

CDC13
Cell division control protein 13

1

0

Small-scale

0.232

Low

736005

PO152
Nucleoporin POM152

1

0

Small-scale

0.232

Low

736019

NUP85
Nucleoporin NUP85

1

0

Small-scale

0.232

Low

736024

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025