Protein: SMC1
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)

Gene: SMC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P32908

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000217 - DNA secondary structure binding
GO:0003677 - DNA binding
GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700779

SMC3
Structural maintenance of chromosomes protein 3

24

17

Small-scale

0.992

High

700808

SCC1
Sister chromatid cohesion protein 1

26

20

Small-scale

0.991

High

700798

SCC2
Sister chromatid cohesion protein 2

6

7

Small-scale

0.939

High

700754

SMC1
Structural maintenance of chromosomes protein 1

2

17

Small-scale

0.781

High

700809

REC8
Meiotic recombination protein REC8

2

1

Small-scale

0.754

High

700774

SCC3
Cohesin subunit SCC3

8

20

Small-scale

0.746

High

693087

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

3

8

Small-scale

0.675

High

700799

PDS5
Sister chromatid cohesion protein PDS5

3

20

Small-scale

0.674

High

521124

RAD50
DNA repair protein RAD50

1

17

High-throughput

0.656

High

700765

SMC2
Structural maintenance of chromosomes protein 2

1

17

High-throughput

0.656

High

700771

SCC4
MAU2 chromatid cohesion factor homolog

3

1

Small-scale

0.640

High

597813

PWP1
Periodic tryptophan protein 1

2

3

High-throughput

0.621

High

700811

SMC4
Structural maintenance of chromosomes protein 4

1

17

Small-scale

0.618

High

700815

SMC6
Structural maintenance of chromosomes protein 6

1

18

High-throughput

0.618

High

490744

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.611

High

557968

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

3

High-throughput

0.584

High

634869

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

700791

TOF1
Topoisomerase 1-associated factor 1

1

1

Small-scale

0.561

High

493545

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

636044

CSM1
Monopolin complex subunit CSM1

2

1

Small-scale

0.539

High

510736

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.536

High

700766

END3
Actin cytoskeleton-regulatory complex protein END3

2

3

High-throughput

0.526

High

660065

KIP2
Kinesin-like protein KIP2

1

2

High-throughput

0.515

High

700781

ARP3
Actin-related protein 3

1

3

High-throughput

0.515

High

700790

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.515

High

456686

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

565186

KAR3
Kinesin-like protein KAR3

1

4

High-throughput

0.508

High

700758

NUF2
Kinetochore protein NUF2

1

4

High-throughput

0.508

High

700760

DYHC
Dynein heavy chain, cytoplasmic

1

2

High-throughput

0.508

High

700777

MAD1
Spindle assembly checkpoint component MAD1

1

10

High-throughput

0.508

High

700783

NNF1
Kinetochore-associated protein NNF1

1

1

High-throughput

0.508

High

700804

BRE1
E3 ubiquitin-protein ligase BRE1

1

12

High-throughput

0.508

High

700801

CSM3
Chromosome segregation in meiosis protein 3

1

1

Small-scale

0.501

High

700812

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.500

High

636013

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.493

High

700761

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.486

High

700776

MET28
Transcriptional activator of sulfur metabolism MET28

1

0

High-throughput

0.486

High

700797

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.486

High

700800

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.486

High

602331

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

Small-scale

0.481

High

608742

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.480

High

588014

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

406920

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

661752

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

664415

HRR25
Casein kinase I homolog HRR25

1

6

Small-scale

0.479

High

664728

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

696187

STH1
Nuclear protein STH1/NPS1

1

8

Small-scale

0.479

High

700759

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

700762

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

700763

SLI15
Inner centromere protein-related protein SLI15

1

1

Small-scale

0.479

High

700768

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

Small-scale

0.479

High

700794

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

700806

SGO1
Shugoshin

1

3

High-throughput

0.479

High

700795

COFI
Cofilin

1

1

High-throughput

0.470

High

700788

NNF2
Protein NNF2

1

1

High-throughput

0.464

High

700789

YG3A
Uncharacterized protein YGR130C

1

8

High-throughput

0.464

High

452085

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.460

High

602473

OPI1
Transcriptional repressor OPI1

1

0

High-throughput

0.460

High

700802

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.460

High

700810

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

700814

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

355421

H2B1
Histone H2B.1

1

12

High-throughput

0.445

High

366034

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

449985

HSP73
Heat shock protein SSA3

1

9

High-throughput

0.445

High

633077

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

694375

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

695927

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.445

High

700756

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

700764

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

700769

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.445

High

700772

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

700780

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

700782

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.445

High

405525

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

407820

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

425852

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

480006

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

480572

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

631769

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

700301

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

700755

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

700757

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

700767

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

700785

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

700796

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

700805

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

700807

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

612218

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

700786

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

541653

SEC63
Protein translocation protein SEC63

1

3

High-throughput

0.407

High

700775

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.407

High

700778

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

700793

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

700803

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

700813

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

692727

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.269

Low

700787

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

383040

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

413405

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

700770

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

700773

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

700784

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

700792

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024