Protein: SN114
Pre-mRNA-splicing factor SNU114 (114 kDa U5 small nuclear ribonucleoprotein component) (Growth inhibitory protein 10)

Gene: SN114, SNU114
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P36048

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000387 - spliceosomal snRNP assembly
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704653

PRP8
Pre-mRNA-splicing factor 8

10

5

Small-scale

0.976

High

731753

LSM3
U6 snRNA-associated Sm-like protein LSm3

6

14

Small-scale

0.938

High

731758

SMD1
Small nuclear ribonucleoprotein Sm D1

4

2

High-throughput

0.896

High

731728

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

3

High-throughput

0.892

High

731740

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

15

Small-scale

0.887

High

731731

RUXG
Small nuclear ribonucleoprotein G

4

14

High-throughput

0.881

High

731750

LSM7
U6 snRNA-associated Sm-like protein LSm7

3

14

High-throughput

0.861

High

589073

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

3

6

High-throughput

0.855

High

731722

LSM2
U6 snRNA-associated Sm-like protein LSm2

3

11

High-throughput

0.855

High

731773

SMD2
Small nuclear ribonucleoprotein Sm D2

3

2

High-throughput

0.855

High

731734

SMD3
Small nuclear ribonucleoprotein Sm D3

3

11

Small-scale

0.839

High

731752

RUXF
Small nuclear ribonucleoprotein F

3

3

High-throughput

0.830

High

731787

RUXE
Small nuclear ribonucleoprotein E

3

2

High-throughput

0.830

High

731729

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

6

High-throughput

0.789

High

731790

PRP46
Pre-mRNA-splicing factor PRP46

2

9

High-throughput

0.789

High

697198

BRR2
Pre-mRNA-splicing helicase BRR2

12

13

Small-scale

0.761

High

731730

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

0

High-throughput

0.761

High

731764

CEF1
Pre-mRNA-splicing factor CEF1

6

2

Small-scale

0.733

High

731763

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.716

High

731784

CWC2
Pre-mRNA-splicing factor CWC2

4

4

High-throughput

0.699

High

731745

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

4

9

High-throughput

0.699

High

731741

PRP31
Pre-mRNA-processing factor 31

4

5

High-throughput

0.694

High

731762

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

4

1

High-throughput

0.694

High

731774

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

3

High-throughput

0.691

High

692282

PRP19
Pre-mRNA-processing factor 19

4

6

Small-scale

0.691

High

731786

CLF1
Pre-mRNA-splicing factor CLF1

4

15

Small-scale

0.691

High

657727

YJU2
Splicing factor YJU2

4

1

Small-scale

0.683

High

731783

RU2A
U2 small nuclear ribonucleoprotein A'

4

8

Small-scale

0.676

High

586391

PRP6
Pre-mRNA-splicing factor 6

3

13

High-throughput

0.662

High

655698

PRP45
Pre-mRNA-processing protein 45

3

3

High-throughput

0.662

High

731755

NAM8
Protein NAM8

3

3

High-throughput

0.662

High

731738

LSM1
Sm-like protein LSm1

1

16

High-throughput

0.656

High

688716

AAR2
A1 cistron-splicing factor AAR2

3

2

Small-scale

0.656

High

731791

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

1

Small-scale

0.650

High

731782

NCBP2
Nuclear cap-binding protein subunit 2

3

9

High-throughput

0.640

High

731724

SP381
Pre-mRNA-splicing factor SPP381

3

0

High-throughput

0.634

High

731747

CWC22
Pre-mRNA-splicing factor CWC22

3

0

High-throughput

0.634

High

589425

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

11

Small-scale

0.633

High

731748

CWC25
Pre-mRNA-splicing factor CWC25

3

0

Small-scale

0.632

High

548528

GCN2
eIF-2-alpha kinase GCN2

2

5

High-throughput

0.621

High

731781

LUC7
Protein LUC7

2

3

High-throughput

0.621

High

731733

PRP17
Pre-mRNA-processing factor 17

1

8

High-throughput

0.618

High

692390

PRP21
Pre-mRNA-splicing factor PRP21

2

1

High-throughput

0.611

High

731777

DIB1
Spliceosomal protein DIB1

2

1

High-throughput

0.611

High

731775

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.602

High

622310

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

2

10

Small-scale

0.595

High

731766

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.586

High

731771

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

731789

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

0

High-throughput

0.585

High

629368

BUD31
Pre-mRNA-splicing factor BUD31

2

3

Small-scale

0.584

High

731769

SYF1
Pre-mRNA-splicing factor SYF1

2

14

Small-scale

0.584

High

731749

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.541

High

691365

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

2

4

High-throughput

0.537

High

510893

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.536

High

731743

CWC23
Pre-mRNA-splicing factor CWC23

1

9

High-throughput

0.536

High

715915

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.518

High

693284

RPN2
26S proteasome regulatory subunit RPN2

1

3

High-throughput

0.515

High

731776

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

731732

MSL1
U2 small nuclear ribonucleoprotein B''

1

9

High-throughput

0.508

High

731744

ATG1
Serine/threonine-protein kinase ATG1

1

3

Small-scale

0.501

High

731735

SAD1
Pre-mRNA-splicing factor SAD1

1

5

Small-scale

0.481

High

355446

H2B1
Histone H2B.1

1

2

High-throughput

0.479

High

355865

H2B2
Histone H2B.2

1

2

High-throughput

0.479

High

356405

H4
Histone H4

1

2

High-throughput

0.479

High

554215

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

11

High-throughput

0.479

High

557999

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.479

High

586482

PRP9
Pre-mRNA-splicing factor PRP9

1

1

High-throughput

0.479

High

598621

ISY1
Pre-mRNA-splicing factor ISY1

1

3

High-throughput

0.479

High

616108

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

6

Small-scale

0.479

High

629955

BPH1
Beige protein homolog 1

1

3

High-throughput

0.479

High

649880

CDC15
Cell division control protein 15

1

3

High-throughput

0.479

High

661903

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

664766

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

691968

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

693990

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

High-throughput

0.479

High

710159

NCBP1
Nuclear cap-binding protein complex subunit 1

1

1

High-throughput

0.479

High

731723

SLT11
Pre-mRNA-splicing factor SLT11

1

2

High-throughput

0.479

High

731727

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

731739

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

731742

SF3B1
U2 snRNP component HSH155

1

9

High-throughput

0.479

High

731751

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.479

High

731754

H3
Histone H3

1

2

High-throughput

0.479

High

731757

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

10

Small-scale

0.479

High

731760

CUS1
Cold sensitive U2 snRNA suppressor 1

1

2

High-throughput

0.479

High

731767

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

15

High-throughput

0.479

High

731768

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

731770

RSE1
Pre-mRNA-splicing factor RSE1

1

3

High-throughput

0.479

High

731779

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.479

High

731780

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

731785

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.479

High

731792

HSH49
Protein HSH49

1

5

High-throughput

0.479

High

696630

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

731720

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

731725

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

731726

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

731736

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

731746

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

731756

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

731761

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

731772

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

731778

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

366111

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

490872

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

493667

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.445

High

627917

SIS1
Protein SIS1

1

12

High-throughput

0.445

High

633129

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

694463

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705038

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.445

High

731737

JJJ2
J protein JJJ2

1

9

High-throughput

0.445

High

696564

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.438

High

692746

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.437

High

731759

SPP2
Pre-mRNA-splicing factor SPP2

1

0

Small-scale

0.426

High

731721

TXTP
Tricarboxylate transport protein

1

4

High-throughput

0.407

High

731788

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.282

High

731765

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024