Protein: SKP1
Suppressor of kinetochore protein 1 (Centromere DNA-binding protein complex CBF3 subunit D) (E3 ubiquitin ligase complex SCF subunit SKP1)

Gene: SKP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 165
UniProt ID: P52286

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000409 - regulation of transcription by galactose
GO:0000776 - kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

460737

CDC4
Cell division control protein 4

28

20

Small-scale

0.993

High

910801

CDC53
Cell division control protein 53

28

20

Small-scale

0.993

High

666699

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

20

20

Small-scale

0.991

High

809273

MET30
F-box protein MET30

21

20

Small-scale

0.989

High

864010

DAS1
F-box protein DAS1

6

1

Small-scale

0.947

High

910782

UFO1
Ubiquitin ligase complex F-box protein UFO1

11

0

Small-scale

0.928

High

843213

SKP2
F-box protein SKP2

7

0

Small-scale

0.913

High

910799

DIA2
Protein DIA2

7

0

Small-scale

0.913

High

910787

MDM30
Mitochondrial distribution and morphology protein 30

6

0

Small-scale

0.898

High

829976

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

6

0

Small-scale

0.894

High

910785

MFB1
Mitochondrial F-box protein MFB1

5

0

Small-scale

0.868

High

910774

RUB1
NEDD8-like protein RUB1

3

1

Small-scale

0.833

High

910759

SKP1
Suppressor of kinetochore protein 1

2

15

Small-scale

0.831

High

910798

SGT1
Protein SGT1

12

1

Small-scale

0.763

High

910809

HRT3
F-box protein HRT3

8

11

Small-scale

0.752

High

865385

RAV1
Regulator of V-ATPase in vacuolar membrane protein 1

9

1

Small-scale

0.750

High

763781

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

14

0

Small-scale

0.733

High

574810

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

6

6

Small-scale

0.730

High

910797

RBX1
RING-box protein HRT1

6

3

Small-scale

0.727

High

910784

ROY1
Non-SCF-type F-box protein ROY1

11

0

Small-scale

0.725

High

798633

SAF1
SCF-associated factor 1

4

1

Small-scale

0.701

High

910792

YL352
F-box protein YLR352W

6

0

Small-scale

0.698

High

812828

RCY1
Recyclin-1

8

1

Small-scale

0.690

High

801179

SIC1
Protein SIC1

5

0

Small-scale

0.685

High

910775

RAV2
Regulator of V-ATPase in vacuolar membrane protein 2

5

0

Small-scale

0.684

High

910773

YD131
F-box protein YDR131C

3

1

Small-scale

0.678

High

910793

YD306
F-box protein YDR306C

3

1

Small-scale

0.678

High

779657

YPT52
GTP-binding protein YPT52

4

0

Small-scale

0.669

High

777081

BDF1
Bromodomain-containing factor 1

1

2

High-throughput

0.656

High

632431

CG12
G1/S-specific cyclin CLN2

3

6

Small-scale

0.650

High

738760

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

4

0

Small-scale

0.648

High

910788

UCC1
F-box protein UCC1

3

0

Small-scale

0.643

High

797368

AMN1
Antagonist of mitotic exit network protein 1

3

20

Small-scale

0.640

High

524553

HSP71
Heat shock protein SSA1

3

3

Small-scale

0.633

High

910813

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.618

High

910810

CSN10
COP9 signalosome complex subunit 10

3

0

High-throughput

0.616

High

826658

DSN1
Kinetochore-associated protein DSN1

3

0

Small-scale

0.613

High

592366

VATB
V-type proton ATPase subunit B

2

2

Small-scale

0.612

High

393035

HSP82
ATP-dependent molecular chaperone HSP82

2

4

Small-scale

0.601

High

603513

VATA
V-type proton ATPase catalytic subunit A

2

4

Small-scale

0.601

High

645845

VATE
V-type proton ATPase subunit E

2

1

Small-scale

0.588

High

743705

VATD
V-type proton ATPase subunit D

2

1

Small-scale

0.588

High

910791

CORO
Coronin-like protein

1

3

High-throughput

0.587

High

527170

HSP72
Heat shock protein SSA2

2

3

Small-scale

0.584

High

579736

HSC82
ATP-dependent molecular chaperone HSC82

2

4

Small-scale

0.584

High

760304

BMH2
Protein BMH2

2

1

Small-scale

0.571

High

734153

EF2
Elongation factor 2

2

1

Small-scale

0.567

High

835510

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

2

Small-scale

0.561

High

867872

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.558

High

819255

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

865897

BIR1
Chromosomal passenger complex protein BIR1

2

0

Small-scale

0.551

High

801980

KIC1
Serine/threonine-protein kinase KIC1

1

1

High-throughput

0.536

High

910771

TDA1
Serine/threonine-protein kinase TDA1

1

3

High-throughput

0.536

High

632392

CG11
G1/S-specific cyclin CLN1

1

7

Small-scale

0.515

High

910811

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.515

High

735526

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

4

High-throughput

0.501

High

748873

SWE1
Mitosis inhibitor protein kinase SWE1

1

2

High-throughput

0.501

High

815351

PAC2
Protein PAC2

1

1

Small-scale

0.501

High

408484

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

Small-scale

0.493

High

825720

CSN11
Cop9 signalosome complex subunit 11

1

0

High-throughput

0.493

High

910776

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.493

High

910794

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.486

High

656542

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

692402

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

910763

HST4
NAD-dependent histone deacetylase HST4

1

0

Small-scale

0.480

High

910800

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.480

High

518336

IF4A
ATP-dependent RNA helicase eIF4A

1

1

Small-scale

0.479

High

645756

HSP74
Heat shock protein SSA4

1

3

Small-scale

0.479

High

679873

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

709875

BMH1
Protein BMH1

1

1

Small-scale

0.479

High

745811

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

Small-scale

0.479

High

745946

GSP2
GTP-binding nuclear protein GSP2/CNR2

1

1

Small-scale

0.479

High

778432

RS27A
Small ribosomal subunit protein eS27A

1

1

Small-scale

0.479

High

813297

FHP
Flavohemoprotein

1

1

Small-scale

0.479

High

818690

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

Small-scale

0.479

High

834712

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

Small-scale

0.479

High

850101

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

910769

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

910779

YM13A
Transposon Ty1-MR1 Gag polyprotein

1

1

Small-scale

0.479

High

625110

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.460

High

858411

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.460

High

865471

BFA1
Mitotic check point protein BFA1

1

0

Small-scale

0.460

High

910768

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.460

High

910778

LIC4
Protein ATC1/LIC4

1

0

High-throughput

0.460

High

910781

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.460

High

514730

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

581882

SYKC
Lysine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

597209

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

670925

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

688921

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.458

High

707637

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

727179

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

733671

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

739513

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

0

Small-scale

0.458

High

740677

CBS
Cystathionine beta-synthase

1

0

Small-scale

0.458

High

779081

EF1G2
Elongation factor 1-gamma 2

1

0

Small-scale

0.458

High

790214

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

Small-scale

0.458

High

795456

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

797342

INCE
Inner centromere protein SLI15

1

0

Small-scale

0.458

High

797892

CENPU
Inner kinetochore subunit AME1

1

0

Small-scale

0.458

High

865358

YJ11B
Transposon Ty1-JR1 Gag-Pol polyprotein

1

0

Small-scale

0.458

High

910760

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.458

High

910767

COFI
Cofilin

1

0

Small-scale

0.458

High

910770

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

910777

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

910780

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

910783

METX
Putative cystathionine gamma-synthase YML082W

1

0

High-throughput

0.458

High

910786

SWR1
Helicase SWR1

1

0

High-throughput

0.458

High

910790

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

910805

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

910807

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

481689

HSP73
Heat shock protein SSA3

1

3

High-throughput

0.445

High

721388

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.445

High

805467

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

High-throughput

0.445

High

811667

VATF
V-type proton ATPase subunit F

1

1

High-throughput

0.445

High

813559

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.445

High

910764

DMA2
E3 ubiquitin-protein ligase DMA2

1

1

High-throughput

0.445

High

415112

ADT1
ADP,ATP carrier protein 1

1

2

Small-scale

0.437

High

452037

TOM70
Mitochondrial import receptor subunit TOM70

1

1

Small-scale

0.437

High

582491

SEC23
Protein transport protein SEC23

1

1

Small-scale

0.437

High

613512

ADT3
ADP,ATP carrier protein 3

1

2

Small-scale

0.437

High

613606

ADT2
ADP,ATP carrier protein 2

1

2

Small-scale

0.437

High

781222

RL14A
Large ribosomal subunit protein eL14A

1

1

Small-scale

0.437

High

802739

RS27B
Small ribosomal subunit protein eS27B

1

1

Small-scale

0.437

High

803412

RL14B
Large ribosomal subunit protein eL14B

1

1

Small-scale

0.437

High

910804

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

1

Small-scale

0.437

High

910806

POM33
Pore membrane protein of 33 kDa

1

1

Small-scale

0.437

High

150297

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.426

High

510977

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.426

High

548915

SCH9
Serine/threonine-protein kinase SCH9

1

0

High-throughput

0.426

High

779289

CENPA
Histone H3-like centromeric protein CSE4

1

0

Small-scale

0.426

High

802796

OSH3
Oxysterol-binding protein homolog 3

1

0

High-throughput

0.426

High

816309

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

835941

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.426

High

836633

MAF1
Repressor of RNA polymerase III transcription MAF1

1

0

High-throughput

0.426

High

910766

STP1
Transcription factor STP1

1

0

High-throughput

0.426

High

910795

CDC45
Cell division control protein 45

1

0

High-throughput

0.426

High

910812

YO098
Uncharacterized protein YOL098C

1

0

High-throughput

0.426

High

395255

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.391

High

910789

BOP2
Protein BOP2

3

0

High-throughput

0.345

High

479990

PRTB
Cerevisin

2

0

High-throughput

0.313

High

910814

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

1

0

Small-scale

0.301

High

797824

CS111
F-box protein COS111

1

0

High-throughput

0.279

Low

910796

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

794317

YB9Z
Inactive deaminase YBR284W

1

0

High-throughput

0.251

Low

367392

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.249

Low

368710

PMG1
Phosphoglycerate mutase 1

1

0

Small-scale

0.249

Low

481906

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

513113

RS8A
Small ribosomal subunit protein eS8A

1

0

Small-scale

0.249

Low

555108

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

621386

METK2
S-adenosylmethionine synthase 2

1

0

Small-scale

0.249

Low

807828

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

812485

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

910803

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

793392

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

0

High-throughput

0.232

Low

813887

YAE5
Putative uncharacterized protein YAL045C

1

0

High-throughput

0.232

Low

830104

FKS2
1,3-beta-glucan synthase component GSC2

1

0

High-throughput

0.232

Low

910761

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.232

Low

910762

ARE2
Sterol O-acyltransferase 2

1

0

High-throughput

0.232

Low

910765

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

0

High-throughput

0.232

Low

910772

YM30
Uncharacterized membrane protein YMR155W

1

0

High-throughput

0.232

Low

910802

YD172
Putative uncharacterized protein YDL172C

1

0

High-throughput

0.232

Low

910808

SUL2
Sulfate permease 2

1

0

Small-scale

0.232

Low

776759

YKF0
Uncharacterized protein YKL050C

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025