Protein: RPN5
26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5)

Gene: RPN5
Organism: Saccharomyces cerevisiae S288C
Interactions: 146
UniProt ID: Q12250

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0000502 - proteasome complex
GO:0005737 - cytoplasm
GO:0008180 - COP9 signalosome
GO:0008541 - proteasome regulatory particle, lid subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850263

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

36

20

Small-scale

0.994

High

1084670

RPN6
26S proteasome regulatory subunit RPN6

21

19

Small-scale

0.988

High

1064740

RPN8
26S proteasome regulatory subunit RPN8

15

20

Small-scale

0.986

High

1044980

RPN9
26S proteasome regulatory subunit RPN9

16

20

Small-scale

0.985

High

738347

RPN12
26S proteasome regulatory subunit RPN12

10

4

Small-scale

0.975

High

1053599

RPN7
26S proteasome regulatory subunit RPN7

10

20

Small-scale

0.974

High

817102

RPN3
26S proteasome regulatory subunit RPN3

10

12

Small-scale

0.974

High

645217

PSB4
Proteasome subunit beta type-4

10

20

Small-scale

0.973

High

750909

PRS6B
26S proteasome regulatory subunit 6B homolog

8

20

Small-scale

0.968

High

751020

PRS7
26S proteasome regulatory subunit 7 homolog

7

20

Small-scale

0.962

High

1033907

PRS8
26S proteasome regulatory subunit 8 homolog

7

20

Small-scale

0.962

High

750803

PRS6A
26S proteasome regulatory subunit 6A

7

20

Small-scale

0.960

High

921115

PRS10
26S proteasome subunit RPT4

7

20

Small-scale

0.960

High

314915

SEM1
26S proteasome complex subunit SEM1

7

1

Small-scale

0.956

High

822446

PRS4
26S proteasome regulatory subunit 4 homolog

6

20

Small-scale

0.947

High

1084672

CSN5
COP9 signalosome complex subunit 5

5

20

Small-scale

0.922

High

636696

PSA1
Proteasome subunit alpha type-1

5

19

Small-scale

0.919

High

662061

PSB6
Proteasome subunit beta type-6

4

20

Small-scale

0.892

High

800867

PSB1
Proteasome subunit beta type-1

4

20

Small-scale

0.892

High

821996

PSA6
Proteasome subunit alpha type-6

4

20

Small-scale

0.892

High

822029

PSA4
Proteasome subunit alpha type-4

4

20

Small-scale

0.886

High

721287

PSB5
Proteasome subunit beta type-5

3

20

Small-scale

0.855

High

636618

PSA7
Probable proteasome subunit alpha type-7

3

20

Small-scale

0.827

High

661573

PSA2
Proteasome subunit alpha type-2

3

19

Small-scale

0.827

High

680164

CDC48
Cell division control protein 48

3

5

Small-scale

0.827

High

1084665

RPN5
26S proteasome regulatory subunit RPN5

3

17

Small-scale

0.817

High

803720

RPN1
26S proteasome regulatory subunit RPN1

11

17

Small-scale

0.756

High

661447

PSA3
Proteasome subunit alpha type-3

2

20

Small-scale

0.754

High

668419

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.754

High

675268

PSB3
Proteasome subunit beta type-3

2

20

Small-scale

0.754

High

721334

PSB7
Proteasome subunit beta type-7

2

20

Small-scale

0.754

High

735969

PSA5
Proteasome subunit alpha type-5

2

19

Small-scale

0.754

High

806839

RPN10
26S proteasome regulatory subunit RPN10

8

5

Small-scale

0.750

High

740236

RPN2
26S proteasome regulatory subunit RPN2

7

16

Small-scale

0.746

High

1044627

CSN9
COP9 signalosome complex subunit 9

7

0

Small-scale

0.717

High

150315

RPN13
26S proteasome regulatory subunit RPN13

5

1

Small-scale

0.714

High

850360

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

5

Small-scale

0.714

High

803181

ECM29
Proteasome component ECM29

5

3

Small-scale

0.712

High

798578

HSM3
DNA mismatch repair protein HSM3

5

1

Small-scale

0.709

High

616465

SEC18
Vesicular-fusion protein SEC18

2

7

High-throughput

0.694

High

918109

RPN14
26S proteasome regulatory subunit RPN14

4

6

Small-scale

0.694

High

1084668

CSN10
COP9 signalosome complex subunit 10

4

1

Small-scale

0.683

High

1046493

CSI1
Cop9 signalosome-interactor 1

4

0

Small-scale

0.654

High

893079

PSD10
Probable 26S proteasome regulatory subunit p28

5

3

Small-scale

0.650

High

825726

CSN11
Cop9 signalosome complex subunit 11

3

0

Small-scale

0.634

High

727404

HS104
Heat shock protein 104

1

3

High-throughput

0.618

High

1084103

CDC53
Cell division control protein 53

1

20

High-throughput

0.618

High

1084673

SKS1
Serine/threonine-protein kinase SKS1

2

1

Small-scale

0.590

High

865880

CSN12
Cop9 signalosome complex subunit 12

1

0

Small-scale

0.586

High

826325

PSMD9
Probable 26S proteasome regulatory subunit p27

2

4

Small-scale

0.584

High

924468

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

5

Small-scale

0.584

High

752888

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.575

High

393526

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

528026

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

1056456

SWA2
Auxilin-like clathrin uncoating factor SWA2

2

3

High-throughput

0.537

High

919647

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.536

High

1043574

ESC1
Silent chromatin protein ESC1

2

1

High-throughput

0.533

High

865920

JSN1
Protein JSN1

1

0

High-throughput

0.518

High

763267

SQT1
Ribosome assembly protein SQT1

1

3

High-throughput

0.515

High

1030611

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.515

High

1084598

TIP41
Type 2A phosphatase activator TIP41

1

1

High-throughput

0.515

High

1084666

IQG1
Ras GTPase-activating-like protein IQG1

1

1

High-throughput

0.515

High

644650

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.513

High

740504

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

Small-scale

0.508

High

509761

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

16

High-throughput

0.501

High

438784

SC160
Protein SCP160

1

0

High-throughput

0.493

High

757806

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.493

High

806185

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

645992

DBF2
Cell cycle protein kinase DBF2

1

1

High-throughput

0.489

High

798007

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.489

High

1044560

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.486

High

416491

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

435438

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

557650

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

5

Small-scale

0.479

High

558903

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

580253

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

674895

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

738941

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

744027

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

776673

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

795596

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

815357

PAC2
Protein PAC2

1

4

Small-scale

0.479

High

815671

LIS1
Nuclear distribution protein PAC1

1

5

Small-scale

0.479

High

849956

BLM10
Proteasome activator BLM10

1

2

Small-scale

0.479

High

917354

HUL5
E3 ubiquitin-protein ligase HUL5

1

7

Small-scale

0.479

High

925139

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

1042833

RPN4
Protein RPN4

1

1

Small-scale

0.479

High

672741

BPH1
Beige protein homolog 1

1

5

High-throughput

0.470

High

726058

FUN30
ATP-dependent helicase FUN30

1

2

High-throughput

0.470

High

757416

TFC3
Transcription factor tau 138 kDa subunit

1

1

High-throughput

0.470

High

813931

ERV46
ER-derived vesicles protein ERV46

1

1

High-throughput

0.470

High

920753

SULX
Putative sulfate transporter YPR003C

1

1

High-throughput

0.470

High

514891

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

782955

JNM1
Nuclear migration protein JNM1

1

0

Small-scale

0.458

High

797541

UMP1
Proteasome maturation factor UMP1

1

0

Small-scale

0.458

High

818070

LSM4
LSM complex subunit LSM4

1

0

Small-scale

0.458

High

865339

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

1040562

ESP1
Separin

1

0

High-throughput

0.458

High

1054892

ESC2
Protein ESC2

1

0

Small-scale

0.458

High

1063931

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

1064514

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

452992

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

453847

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

510909

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

525560

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

546757

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

742682

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

820127

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

721676

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.438

High

603122

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.437

High

647249

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

671247

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

679061

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

708539

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

823102

VPS27
Vacuolar protein sorting-associated protein 27

1

1

Small-scale

0.437

High

844664

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

877938

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

917336

INO80
Chromatin-remodeling ATPase INO80

1

2

Small-scale

0.437

High

1044843

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

1054872

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

1084671

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

1084667

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

577246

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

689165

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.407

High

811436

CAJ1
Protein CAJ1

1

3

High-throughput

0.407

High

808232

SNF11
Transcription regulatory protein SNF11

1

0

Small-scale

0.282

High

635997

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

737996

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.279

Low

745399

EMP24
Endosomal protein P24B

1

0

High-throughput

0.279

Low

745509

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.269

Low

813400

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.269

Low

863077

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.269

Low

1060651

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.269

Low

1084669

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.269

Low

1084675

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.269

Low

677622

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

824811

MLP2
Protein MLP2

1

0

High-throughput

0.249

Low

826936

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

1065537

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1084674

SLO1
SCOCO-like protein 1

1

0

High-throughput

0.249

Low

1051192

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.238

Low

410398

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

434101

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

442173

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.232

Low

863897

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025