Protein: CD8A
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)

Gene: CD8A
Organism: Homo sapiens
Interactions: 19
UniProt ID: P01732

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002456 - T cell mediated immunity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378901

HLAG
HLA class I histocompatibility antigen, alpha chain G

3

3

Small-scale

0.840

High

378898

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

3

Small-scale

0.768

High

378895

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

3

Small-scale

0.755

High

378894

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

Small-scale

0.687

High

378893

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

Small-scale

0.618

High

378904

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

4

Small-scale

0.618

High

378897

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

0

Small-scale

0.614

High

378896

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.584

High

378908

SLF1
SMC5-SMC6 complex localization factor protein 1

1

0

High-throughput

0.578

High

378892

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

1

Small-scale

0.575

High

378906

LNX2
Ligand of Numb protein X 2

1

1

Small-scale

0.573

High

378903

COPA
Coatomer subunit alpha

1

0

Small-scale

0.517

High

378899

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

378907

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.512

High

378902

CALR
Calreticulin

1

0

High-throughput

0.493

High

378900

CD59
CD59 glycoprotein

1

0

Small-scale

0.480

High

378909

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.282

High

378905

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025