Protein: CD3D
T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

Gene: CD3D
Organism: Homo sapiens
Interactions: 86
UniProt ID: P04234

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378894

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

0

Small-scale

0.687

High

407150

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.656

High

407160

ZAP70
Tyrosine-protein kinase ZAP-70

2

6

Small-scale

0.584

High

407149

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.575

High

407163

TERA
Transitional endoplasmic reticulum ATPase

2

0

Small-scale

0.559

High

407155

CALX
Calnexin

2

1

Small-scale

0.558

High

407191

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

1

Small-scale

0.558

High

407222

AMFR
E3 ubiquitin-protein ligase AMFR

2

1

Small-scale

0.549

High

332196

UCP5
Brain mitochondrial carrier protein 1

1

1

High-throughput

0.536

High

407165

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.536

High

407173

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.536

High

407178

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.536

High

407188

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

2

High-throughput

0.536

High

407197

LMBR1
Limb region 1 protein homolog

1

1

High-throughput

0.536

High

407210

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.536

High

322689

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.513

High

407158

CXG1
Gap junction gamma-1 protein

1

0

High-throughput

0.513

High

407159

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

407161

GLRB
Glycine receptor subunit beta

1

0

High-throughput

0.513

High

407162

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.513

High

407166

AT8B2
Phospholipid-transporting ATPase ID

1

0

High-throughput

0.513

High

407168

ATP7A
Copper-transporting ATPase 1

1

0

High-throughput

0.513

High

407170

SRBP2
Sterol regulatory element-binding protein 2

1

0

High-throughput

0.513

High

407175

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.513

High

407185

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.513

High

407187

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

407190

AGRG6
Adhesion G-protein coupled receptor G6

1

0

High-throughput

0.513

High

407192

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

407200

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.513

High

407203

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.513

High

407207

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

0

High-throughput

0.513

High

407209

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.513

High

407218

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

407219

CNNM1
Metal transporter CNNM1

1

0

High-throughput

0.513

High

407220

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

170608

CLGN
Calmegin

1

1

High-throughput

0.489

High

227013

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

3

High-throughput

0.489

High

407167

TAP2
Antigen peptide transporter 2

1

1

High-throughput

0.489

High

407179

KMCP1
Kidney mitochondrial carrier protein 1

1

1

High-throughput

0.489

High

407211

S2533
Solute carrier family 25 member 33

1

3

High-throughput

0.489

High

407225

ORNT1
Mitochondrial ornithine transporter 1

1

2

High-throughput

0.489

High

407152

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

Small-scale

0.480

High

403723

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

407148

FYN
Tyrosine-protein kinase Fyn

1

1

Small-scale

0.479

High

407156

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

407157

SHC1
SHC-transforming protein 1

1

5

Small-scale

0.479

High

407164

GRB2
Growth factor receptor-bound protein 2

1

3

Small-scale

0.479

High

240459

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

321145

ERLN2
Erlin-2

1

0

Small-scale

0.458

High

407196

WDR20
WD repeat-containing protein 20

1

0

Small-scale

0.458

High

407223

UBQL1
Ubiquilin-1

1

0

Small-scale

0.458

High

407154

ITB8
Integrin beta-8

1

0

High-throughput

0.426

High

407224

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.426

High

407201

TM186
Transmembrane protein 186

1

1

High-throughput

0.407

High

407202

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

0

High-throughput

0.316

High

407198

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

0

High-throughput

0.313

High

407151

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

407153

COT2
COUP transcription factor 2

1

0

High-throughput

0.279

Low

407169

TMM62
Transmembrane protein 62

1

0

High-throughput

0.279

Low

407177

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

407181

SZT2
KICSTOR complex protein SZT2

1

0

High-throughput

0.279

Low

407182

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

407183

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

0

High-throughput

0.279

Low

407184

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

407186

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

1

0

High-throughput

0.279

Low

407189

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.279

Low

407193

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.279

Low

407194

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.279

Low

407195

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

0

High-throughput

0.279

Low

407199

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.279

Low

407204

FACR2
Fatty acyl-CoA reductase 2

1

0

High-throughput

0.279

Low

407205

TM87B
Transmembrane protein 87B

1

0

High-throughput

0.279

Low

407206

F210B
Protein FAM210B, mitochondrial

1

0

High-throughput

0.279

Low

407208

LMF1
Lipase maturation factor 1

1

0

High-throughput

0.279

Low

407213

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

0

High-throughput

0.279

Low

407214

OSGL1
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

407215

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

407216

NSUN3
tRNA

1

0

High-throughput

0.279

Low

407217

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.279

Low

407221

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.279

Low

407171

PDIA2
Protein disulfide-isomerase A2

1

0

Small-scale

0.249

Low

407172

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.249

Low

407174

Q14342
FYN protein

1

0

Small-scale

0.249

Low

407212

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

407176

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.232

Low

407180

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025