Protein: ATR
Serine/threonine-protein kinase MEC1 (EC 2.7.11.1) (ATR homolog) (DNA-damage checkpoint kinase MEC1) (Mitosis entry checkpoint protein 1)

Gene: ATR, MEC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 96
UniProt ID: P38111

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000722 - telomere maintenance via recombination
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

744168

LCD1
DNA damage checkpoint protein LCD1

18

1

Small-scale

0.990

High

607259

RFA1
Replication factor A protein 1

12

8

Small-scale

0.761

High

605984

RAD53
Serine/threonine-protein kinase RAD53

11

8

Small-scale

0.758

High

644752

RFA2
Replication factor A protein 2

9

10

Small-scale

0.755

High

644797

RFA3
Replication factor A protein 3

4

0

Small-scale

0.667

High

744129

ATR
Serine/threonine-protein kinase MEC1

1

17

Small-scale

0.647

High

744175

IES4
Ino eighty subunit 4

2

1

Small-scale

0.629

High

744147

DPB11
DNA replication regulator DPB11

2

7

Small-scale

0.626

High

744166

MSH6
DNA mismatch repair protein MSH6

2

6

High-throughput

0.621

High

698255

CDC13
Cell division control protein 13

2

1

Small-scale

0.602

High

715634

SGS1
ATP-dependent helicase SGS1

2

13

Small-scale

0.602

High

744152

TEL2
Telomere length regulation protein TEL2

2

1

Small-scale

0.584

High

744154

ATG1
Serine/threonine-protein kinase ATG1

2

11

Small-scale

0.584

High

744134

RAD55
DNA repair protein RAD55

2

0

Small-scale

0.577

High

744170

ATG13
Autophagy-related protein 13

2

1

Small-scale

0.576

High

549726

STI1
Heat shock protein STI1

2

9

High-throughput

0.574

High

539921

RAD9
DNA repair protein RAD9

2

0

Small-scale

0.569

High

519583

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

High-throughput

0.567

High

604543

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

Small-scale

0.564

High

744155

INO80
Chromatin-remodeling ATPase INO80

1

9

Small-scale

0.561

High

697912

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

3

High-throughput

0.541

High

744130

PAF1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.537

High

744131

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.537

High

744153

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.537

High

567965

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

715319

SPT7
Transcriptional activator SPT7

1

19

High-throughput

0.536

High

744145

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

744156

SGF73
SAGA-associated factor 73

1

6

High-throughput

0.536

High

584153

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.513

High

629893

YCP4
Flavoprotein-like protein YCP4

1

0

High-throughput

0.513

High

744143

MSL1
U2 small nuclear ribonucleoprotein B''

1

5

High-throughput

0.508

High

419862

SNF1
Carbon catabolite-derepressing protein kinase

1

4

Small-scale

0.501

High

516296

RAP1
DNA-binding protein RAP1

1

1

Small-scale

0.501

High

623814

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

16

Small-scale

0.501

High

744136

DUN1
DNA damage response protein kinase DUN1

1

20

Small-scale

0.501

High

604676

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.493

High

744137

SNF7
Vacuolar-sorting protein SNF7

1

3

High-throughput

0.489

High

744157

IST1
Vacuolar protein sorting-associated protein IST1

1

1

High-throughput

0.489

High

744164

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

634875

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.480

High

699058

RE114
Meiotic recombination protein REC114

1

0

Small-scale

0.480

High

710413

PIN4
RNA-binding protein PIN4

1

0

Small-scale

0.480

High

498499

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

543595

HSC82
ATP-dependent molecular chaperone HSC82

1

14

High-throughput

0.479

High

603305

SNF2
Transcription regulatory protein SNF2

1

9

Small-scale

0.479

High

627947

SIS1
Protein SIS1

1

7

Small-scale

0.479

High

661999

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

715671

TAF14
Transcription initiation factor TFIID subunit 14

1

6

Small-scale

0.479

High

744133

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

8

High-throughput

0.479

High

744135

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

4

Small-scale

0.479

High

744149

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

744159

ARP5
Actin-related protein 5

1

2

Small-scale

0.479

High

744160

ARP4
Actin-related protein 4

1

6

Small-scale

0.479

High

744161

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.479

High

744162

NHP10
Non-histone protein 10

1

7

Small-scale

0.479

High

744167

RUVB1
RuvB-like protein 1

1

19

Small-scale

0.479

High

744172

CDC73
Cell division control protein 73

1

2

Small-scale

0.479

High

744173

ASA1
ASTRA-associated protein 1

1

1

Small-scale

0.479

High

744176

HFI1
Transcriptional coactivator HFI1/ADA1

1

2

Small-scale

0.479

High

744179

IES3
Ino eighty subunit 3

1

1

Small-scale

0.479

High

744180

ARP8
Actin-like protein ARP8

1

2

Small-scale

0.479

High

744182

RUVB2
RuvB-like protein 2

1

19

Small-scale

0.479

High

446985

EI2BG
Translation initiation factor eIF2B subunit gamma

1

3

High-throughput

0.470

High

744132

BZZ1
Protein BZZ1

1

2

High-throughput

0.470

High

744163

THADA
tRNA

1

1

High-throughput

0.470

High

744181

LAS17
Proline-rich protein LAS17

1

7

High-throughput

0.470

High

696938

IES6
Chromatin-remodeling complex subunit IES6

1

0

Small-scale

0.458

High

744139

IES5
Ino eighty subunit 5

1

0

Small-scale

0.458

High

744141

IES2
Ino eighty subunit 2

1

0

Small-scale

0.458

High

744144

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

744148

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

366161

HSP82
ATP-dependent molecular chaperone HSP82

1

14

High-throughput

0.445

High

450017

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.445

High

478127

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.445

High

490975

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

493754

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

511020

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

633154

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

680640

HS104
Heat shock protein 104

1

6

High-throughput

0.445

High

694538

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705084

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

744138

HSP7E
Heat shock protein SSC3, mitochondrial

1

8

High-throughput

0.445

High

744140

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

744142

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.445

High

744151

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

High-throughput

0.445

High

744158

APJ1
J domain-containing protein APJ1

1

8

High-throughput

0.445

High

744174

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

744177

SMT3
Ubiquitin-like protein SMT3

1

4

Small-scale

0.408

High

744146

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

744150

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

744171

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.407

High

744178

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

660323

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

744165

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

744169

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024