Protein: SERA
D-3-phosphoglycerate dehydrogenase 1 (3-PGDH 1) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399)

Gene: SERA, SER3
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P40054

Gene Ontology (top 5):
GO:0004617 - phosphoglycerate dehydrogenase activity
GO:0005737 - cytoplasm
GO:0006564 - L-serine biosynthetic process
GO:0051287 - NAD binding
GO:0061759 - alpha-ketoglutarate reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817560

SER33
D-3-phosphoglycerate dehydrogenase 2

9

16

Small-scale

0.969

High

817559

SERA
D-3-phosphoglycerate dehydrogenase 1

3

15

High-throughput

0.829

High

762827

TOR1
Serine/threonine-protein kinase TOR1

2

1

Small-scale

0.594

High

579471

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.584

High

744554

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

1

High-throughput

0.541

High

751265

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

3

High-throughput

0.541

High

792405

BOI1
BEM1-interacting protein 1

1

7

High-throughput

0.541

High

813689

BDH1
(R,R)-butanediol dehydrogenase

1

1

High-throughput

0.541

High

817574

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

2

High-throughput

0.541

High

721972

XPO1
Exportin-1

1

2

High-throughput

0.536

High

817562

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

817561

MAF1
Repressor of RNA polymerase III transcription MAF1

1

0

High-throughput

0.518

High

817570

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.518

High

584233

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

4

High-throughput

0.494

High

817564

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.494

High

806285

KOG1
Target of rapamycin complex 1 subunit KOG1

1

7

High-throughput

0.481

High

750676

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

752309

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

760591

TSA1
Peroxiredoxin TSA1

1

6

Small-scale

0.479

High

803558

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

817563

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

817571

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

2

High-throughput

0.479

High

794298

PPS1
Dual specificity protein phosphatase PPS1

1

2

High-throughput

0.464

High

817566

NU116
Nucleoporin NUP116/NSP116

1

1

High-throughput

0.464

High

524078

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

526802

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

545030

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

741665

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

402017

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.437

High

433668

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

441934

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

455089

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

513032

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

670762

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

679733

CDC48
Cell division control protein 48

1

3

High-throughput

0.437

High

707213

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

747394

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

817565

YPT32
GTP-binding protein YPT32/YPT11

1

1

High-throughput

0.437

High

817567

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.437

High

796243

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

High-throughput

0.282

High

817572

TMS1
Membrane protein TMS1

1

0

High-throughput

0.282

High

817573

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.282

High

801992

PPAC
Acid phosphatase PHO12

1

0

High-throughput

0.269

Low

594392

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.249

Low

758474

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.249

Low

806723

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

817568

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

817569

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

804988

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025