Protein: TSA1
Peroxiredoxin TSA1 (Prx) (EC 1.11.1.24) (Cytoplasmic thiol peroxidase 1) (cTPx 1) (Protector protein) (PRP) (Thiol-specific antioxidant protein 1) (Thioredoxin peroxidase type Ia) (TPx type Ia) (Thioredoxin-dependent peroxide reductase) (Thioredoxin-dependent peroxiredoxin TSA1)

Gene: TSA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 136
UniProt ID: P34760

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006111 - regulation of gluconeogenesis
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

760566

TSA1
Peroxiredoxin TSA1

11

14

Small-scale

0.975

High

652865

TRX2
Thioredoxin-2

5

20

Small-scale

0.930

High

646595

TRX1
Thioredoxin-1

4

20

Small-scale

0.886

High

760624

TSA2
Peroxiredoxin TSA2

3

14

High-throughput

0.854

High

760572

SRX1
Sulfiredoxin

2

5

Small-scale

0.768

High

741303

HSP7F
Heat shock protein homolog SSE1

3

11

High-throughput

0.662

High

670555

SIS1
Protein SIS1

3

1

High-throughput

0.640

High

760601

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

3

High-throughput

0.640

High

523543

HSP71
Heat shock protein SSA1

3

8

Small-scale

0.633

High

544381

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

Small-scale

0.595

High

760593

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

Small-scale

0.585

High

760595

MLP2
Protein MLP2

3

4

Small-scale

0.585

High

526340

HSP72
Heat shock protein SSA2

2

8

Small-scale

0.584

High

579154

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.584

High

737821

HOG1
Mitogen-activated protein kinase HOG1

2

10

High-throughput

0.584

High

760618

IMA1
Importin subunit alpha

2

1

Small-scale

0.576

High

365007

KPYK1
Pyruvate kinase 1

1

1

Small-scale

0.561

High

626491

AP1
AP-1-like transcription factor YAP1

1

0

Small-scale

0.554

High

760644

SMC6
Structural maintenance of chromosomes protein 6

2

2

High-throughput

0.543

High

760599

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.536

High

760608

MPA43
Protein MPA43

1

2

High-throughput

0.536

High

760609

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

760614

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

760621

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

760616

UBC7
Ubiquitin-conjugating enzyme E2 7

2

2

High-throughput

0.535

High

760633

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

Small-scale

0.513

High

376185

RAS1
Ras-like protein 1

1

4

High-throughput

0.508

High

743815

FRDS
Fumarate reductase 1

1

1

Small-scale

0.501

High

536101

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.500

High

760571

VPS21
Vacuolar protein sorting-associated protein 21

1

4

High-throughput

0.500

High

760625

CAF1B
Chromatin assembly factor 1 subunit B

1

6

High-throughput

0.500

High

760568

SPT7
SAGA complex subunit SPT7

1

2

High-throughput

0.489

High

760598

CRS5
Metallothionein-like protein CRS5

1

1

Small-scale

0.481

High

760630

DPP3
Probable dipeptidyl peptidase 3

1

0

Small-scale

0.480

High

760640

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.479

High

361429

SODC
Superoxide dismutase [Cu-Zn]

1

5

High-throughput

0.479

High

392519

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.479

High

433558

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

441091

KAPA
cAMP-dependent protein kinase type 1

1

2

Small-scale

0.479

High

454619

PROF
Profilin

1

3

High-throughput

0.479

High

469987

FUMH
Fumarate hydratase, mitochondrial

1

3

High-throughput

0.479

High

645711

HSP74
Heat shock protein SSA4

1

8

High-throughput

0.479

High

646362

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

647742

RFA1
Replication factor A protein 1

1

5

Small-scale

0.479

High

675886

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.479

High

679549

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

726915

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

734061

EF2
Elongation factor 2

1

6

High-throughput

0.479

High

750615

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

757691

EDE1
EH domain-containing and endocytosis protein 1

1

3

Small-scale

0.479

High

760567

TOR1
Serine/threonine-protein kinase TOR1

1

1

Small-scale

0.479

High

760575

ATG8
Autophagy-related protein 8

1

20

High-throughput

0.479

High

760576

QOR
Probable quinone oxidoreductase

1

1

Small-scale

0.479

High

760578

YB8A
Putative uncharacterized protein YBR285W

1

1

Small-scale

0.479

High

760579

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.479

High

760581

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

4

High-throughput

0.479

High

760582

DNPEP
Aspartyl aminopeptidase 4

1

1

High-throughput

0.479

High

760586

TCPZ
T-complex protein 1 subunit zeta

1

7

High-throughput

0.479

High

760587

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

760590

RSP5
E3 ubiquitin-protein ligase RSP5

1

7

High-throughput

0.479

High

760591

SERA
D-3-phosphoglycerate dehydrogenase 1

1

6

Small-scale

0.479

High

760600

OTU1
Ubiquitin thioesterase OTU1

1

3

High-throughput

0.479

High

760607

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

760615

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

760620

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

760623

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

760628

SUB2
ATP-dependent RNA helicase SUB2

1

5

Small-scale

0.479

High

760629

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

1

High-throughput

0.479

High

760642

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

360962

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

410043

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

416412

HXKA
Hexokinase-1

1

0

Small-scale

0.458

High

430826

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.458

High

435883

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441826

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

454725

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

454975

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

502961

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

504142

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

514558

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

645358

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

674530

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

734924

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

747278

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

751281

BUD2
Inhibitory regulator protein BUD2/CLA2

1

0

Small-scale

0.458

High

753283

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

760569

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

760573

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.458

High

760577

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

760580

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.458

High

760583

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

760588

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

760589

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

760597

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

760604

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

760610

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

760613

DAK1
Dihydroxyacetone kinase 1

1

0

Small-scale

0.458

High

760631

SGO1
Shugoshin

1

0

High-throughput

0.458

High

760635

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

760585

SEC31
Protein transport protein SEC31

1

7

High-throughput

0.457

High

692326

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

760594

6P21
6-phosphofructo-2-kinase 1

1

4

High-throughput

0.445

High

594300

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.437

High

706714

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

752954

IXR1
Intrastrand cross-link recognition protein

1

6

Small-scale

0.437

High

760611

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

760612

ORC1
Origin recognition complex subunit 1

1

5

High-throughput

0.437

High

760619

YMZ2
WD repeat-containing protein YMR102C

1

8

Small-scale

0.437

High

760632

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

760636

HOSM
Homocitrate synthase, mitochondrial

1

1

Small-scale

0.437

High

760637

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

760639

ERV2
FAD-linked sulfhydryl oxidase ERV2

1

1

High-throughput

0.437

High

760641

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

419685

H2A2
Histone H2A.2

1

3

High-throughput

0.407

High

760574

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

6

High-throughput

0.407

High

760592

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

2

High-throughput

0.407

High

760606

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

760643

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.407

High

401957

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.305

High

760596

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.298

High

760602

FIP1
Pre-mRNA polyadenylation factor FIP1

1

0

High-throughput

0.279

Low

675284

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.261

Low

748159

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

760627

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

605103

TPM1
Tropomyosin-1

1

0

Small-scale

0.249

Low

676624

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

760570

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

760603

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

760605

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

760622

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

760626

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

760638

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

760584

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

760617

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.232

Low

760634

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025