Protein: PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)

Gene: PDE4A
Organism: Homo sapiens
Interactions: 27
UniProt ID: P27815

Gene Ontology (top 5):
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006198 - cAMP catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

698209

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

7

High-throughput

0.691

High

276672

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

6

High-throughput

0.628

High

591925

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

2

High-throughput

0.606

High

156550

C56D2
Transmembrane reductase CYB561D2

2

0

High-throughput

0.580

High

698218

OSGI1
Oxidative stress-induced growth inhibitor 1

2

1

High-throughput

0.553

High

698203

IP3KB
Inositol-trisphosphate 3-kinase B

1

1

High-throughput

0.536

High

698213

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

6

High-throughput

0.536

High

698214

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

6

High-throughput

0.536

High

698215

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

6

High-throughput

0.536

High

698219

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

6

High-throughput

0.536

High

698212

SQSTM
Sequestosome-1

1

1

Small-scale

0.515

High

280518

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.515

High

698206

CASP6
Caspase-6

1

1

High-throughput

0.515

High

698220

SHLB1
Endophilin-B1

1

1

High-throughput

0.515

High

698204

VEGFB
Vascular endothelial growth factor B

1

0

High-throughput

0.513

High

463350

LYN
Tyrosine-protein kinase Lyn

1

6

Small-scale

0.501

High

698217

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.501

High

650607

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.493

High

698205

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.493

High

561908

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

698207

HEN2
Helix-loop-helix protein 2

1

1

High-throughput

0.489

High

568762

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

5

Small-scale

0.479

High

629582

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

698208

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.479

High

698210

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

698211

AKAP6
A-kinase anchor protein 6

1

2

Small-scale

0.479

High

698216

LARP7
La-related protein 7

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025